leojaponin: from Leonurus japonicus leaves; structure in first source [MeSH]
| ID Source | ID |
|---|---|
| PubMed CID | 12187536 |
| CHEMBL ID | 4753034 |
| MeSH ID | M0501252 |
| Synonym |
|---|
| leojaponin |
| 864817-63-0 |
| (4ar)-4-[2-(furan-3-yl)ethyl]-1-hydroxy-3,4a,8,8-tetramethyl-6,7-dihydro-5h-naphthalen-2-one |
| CHEMBL4753034 |
| AKOS040761979 |
| HY-N8319 |
| CS-0143076 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1676559 | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 2 hrs followed by LPS addition and measured after 18 hrs by Griess reagent-based assay | 2020 | Journal of natural products, 09-25, Volume: 83, Issue:9 ISSN: 1520-6025 | Structurally Diverse Labdane Diterpenoids from |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| gallic acid | trihydroxybenzoic acid | antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite | 2017 | 2017 | 7.0 | high | 0 | 0 | 0 | 0 | 1 | 0 | |
| glutamic acid | glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical | 2010 | 2010 | 14.0 | high | 0 | 0 | 0 | 1 | 0 | 0 | |
| nigericin | polycyclic ether | antibacterial agent; antimicrobial agent; bacterial metabolite; potassium ionophore | 2021 | 2021 | 3.0 | high | 0 | 0 | 0 | 0 | 0 | 1 | |
| leonurine | trihydroxybenzoic acid | 2017 | 2017 | 7.0 | high | 0 | 0 | 0 | 0 | 1 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arthritis, Gouty | 0 | 2021 | 2021 | 3.0 | high | 0 | 0 | 0 | 0 | 0 | 1 | |
| Gouty Arthritis | 0 | 2021 | 2021 | 3.0 | high | 0 | 0 | 0 | 0 | 0 | 1 |
| Article | Year |
|---|---|
| Three diterpenes from Leonurus japonicus Houtt protect primary cultured rat cortical cells from glutamate-induced toxicity. Phytotherapy research : PTR, , Volume: 24, Issue:8 | 2010 |