l 670548 has been researched along with arecoline in 2 studies
*Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands. [MeSH]
*Arecoline: An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors. It is used in the form of various salts as a ganglionic stimulant, a parasympathomimetic, and a vermifuge, especially in veterinary practice. It has been used as a euphoriant in the Pacific Islands. [MeSH]
| Studies (l 670548) | Trials (l 670548) | Recent Studies (post-2010) (l 670548) | Studies (arecoline) | Trials (arecoline) | Recent Studies (post-2010) (arecoline) |
|---|---|---|---|---|---|
| 7 | 0 | 0 | 1,110 | 20 | 271 |
| Protein | Taxonomy | l 670548 (IC50) | arecoline (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 3.6 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 1.011 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.963 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.963 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.963 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.9163 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.115 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baker, R; Book, T; Freedman, SB; Marwood, RS; Patel, S; Reeve, AJ; Saunders, J; Street, LJ; Willson, T | 1 |
| Baker, R; Book, T; Freedman, SB; Herbert, RH; Kneen, CO; MacLeod, AM; Merchant, KJ; Saunders, J; Showell, GA; Street, LJ | 1 |
2 other study(ies) available for l 670548 and arecoline
| Article | Year |
|---|---|
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.
Topics: Animals; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Norbornanes; Parasympathomimetics; Pyrazines; Quinuclidines; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1992 |
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.
Topics: Animals; Cerebral Cortex; In Vitro Techniques; Ligands; Oxadiazoles; Parasympathomimetics; Rats; Receptors, Muscarinic; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 1990 |