l 670548 has been researched along with carbachol in 5 studies
| Studies (l 670548) | Trials (l 670548) | Recent Studies (post-2010) (l 670548) | Studies (carbachol) | Trials (carbachol) | Recent Studies (post-2010) (carbachol) |
|---|---|---|---|---|---|
| 7 | 0 | 0 | 13,918 | 81 | 968 |
| Protein | Taxonomy | l 670548 (IC50) | carbachol (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.7849 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 2.0626 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 3.4134 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 2.9961 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 2.535 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 2.9961 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 2.6638 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 4.849 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 4.99 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baker, R; Davis, J; Freedman, SB; Hargreaves, R; Hoogsteen, K; Patel, S; Showell, GA; Snow, RJ | 1 |
| Baker, R; Book, T; Freedman, SB; Marwood, RS; Patel, S; Reeve, AJ; Saunders, J; Street, LJ; Willson, T | 1 |
| Baker, R; Book, T; Freedman, SB; Herbert, RH; Kneen, CO; MacLeod, AM; Merchant, KJ; Saunders, J; Showell, GA; Street, LJ | 1 |
| Kover, A; Semus, SF; Wu, ES | 1 |
| Fisher, SK; Thompson, AK | 1 |
5 other study(ies) available for l 670548 and carbachol
| Article | Year |
|---|---|
Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.
Topics: Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Electrophysiology; Ganglia, Sympathetic; Guinea Pigs; Heart Rate; Ileum; Male; Molecular Conformation; Molecular Structure; Muscle Contraction; Myenteric Plexus; N-Methylscopolamine; Oxadiazoles; Parasympathomimetics; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine Derivatives; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction | 1992 |
Synthesis and muscarinic activity of quinuclidinyl- and (1-azanorbornyl)pyrazine derivatives.
Topics: Animals; Binding, Competitive; Cerebral Cortex; In Vitro Techniques; Norbornanes; Parasympathomimetics; Pyrazines; Quinuclidines; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 1992 |
Synthesis and biological activity of 1,2,4-oxadiazole derivatives: highly potent and efficacious agonists for cortical muscarinic receptors.
Topics: Animals; Cerebral Cortex; In Vitro Techniques; Ligands; Oxadiazoles; Parasympathomimetics; Rats; Receptors, Muscarinic; Receptors, Nicotinic; Stereoisomerism; Structure-Activity Relationship | 1990 |
Synthesis and modeling studies of a potent conformationally rigid muscarinic agonist: 1-azabicyclo[2.2.1]heptanespirofuranone.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Cyclic AMP; Guinea Pigs; Hippocampus; Hydrolysis; In Vitro Techniques; Models, Molecular; Molecular Conformation; Muscarinic Agonists; Myocardium; Phosphatidylinositols; Rats; Spiro Compounds; Structure-Activity Relationship | 1998 |
Preferential coupling of cell surface muscarinic receptors to phosphoinositide hydrolysis in human neuroblastoma cells.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Carbachol; Chromatography, High Pressure Liquid; Humans; Hydrolysis; Neuroblastoma; Oxadiazoles; Phosphatidylinositols; Radioligand Assay; Receptors, Cholinergic; Receptors, Muscarinic; Scopolamine; Temperature; Tumor Cells, Cultured | 1991 |