farnesiferol C: an antiangiogenic and antineoplastic agent; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 15559239 |
| CHEMBL ID | 177697 |
| MeSH ID | M0551488 |
| Synonym |
|---|
| farnesiferol c |
| CHEMBL177697 , |
| 512-17-4 |
| unii-56p18t724f |
| 56p18t724f , |
| coumarin, 7-((3-methyl-5-(1.beta.,3,3-trimethyl-7-oxabicyclo(2.2.1)hept-2.alpha.-yl)-2-pentenyl)oxy)- |
| 2h-1-benzopyran-2-one, 7-(((2e)-3-methyl-5-((1s,2r,4r)-1,3,3-trimethyl-7-oxabicyclo(2.2.1)hept-2-yl)-2-penten-1-yl)oxy)- |
| farnesylferol c |
| 2h-1-benzopyran-2-one, 7-((3-methyl-5-(1,3,3-trimethyl-7-oxabicyclo(2.2.1)hept-2-yl)-2-pentenyl)oxy)-, (1s-(1.alpha.,2.alpha.(e),4.alpha.))- |
| 7-[(e)-3-methyl-5-[(1s,2r,4r)-1,3,3-trimethyl-7-oxabicyclo[2.2.1]heptan-2-yl]pent-2-enoxy]chromen-2-one |
| Q27261410 |
| 7-[(e)-3-methyl-5-[(1r,3r,4s)-2,2,4-trimethyl-7-oxabicyclo[2.2.1]heptan-3-yl]pent-2-enoxy]chromen-2-one |
| DTXSID601317173 |
| 2h-1-benzopyran-2-one, 7-((3-methyl-5-(1,3,3-trimethyl-7-oxabicyclo(2.2.1)hept-2-yl)-2-pentenyl)oxy)-, (1s-(1alpha,2alpha(e),4alpha))- |
| coumarin, 7-((3-methyl-5-(1beta,3,3-trimethyl-7-oxabicyclo(2.2.1)hept-2alpha-yl)-2-pentenyl)oxy)- |
| AKOS040748343 |
Farnesiferol C (FC) is a sesquiterpene coumarin, with a unique chemical structure. isolated from Ferula (Apiaceae) species including Ferula assa-foetida and Ferula szowitsiana.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Farnesiferol C (FC) is a well-known biologically active sesquiterpene coumarin derivative from genus Ferula." | ( Structural and kinetic insights into HIV-1 reverse transcriptase inhibition by farnesiferol C. Dehghan, G; Sadeghi, L; Sistani, P, 2021) | 1.57 |
| "Farnesiferol C (FC) is a sesquiterpene coumarin, with a unique chemical structure, isolated from Ferula (Apiaceae) species including Ferula assa-foetida and Ferula szowitsiana. " | ( Biological activities of farnesiferol C: a review. Kasaian, J; Mohammadi, A, 2018) | 2.23 |
| "Farnesiferol C (FC) is a natural sesquiterpene coumarin, which includes a widely range of biological activities. " | ( The inhibitory effect of farnesiferol C against catalase; Kinetics, interaction mechanism and molecular docking simulation. Dehghan, G; Ghadari, R; Moosavi-Movahedi, AA; Rashtbari, S; Yekta, R, 2018) | 2.23 |
| "Farnesiferol C is a natural compound with various anti-cancer properties that belongs to the class of sesquiterpene coumarins. " | ( Anti-proliferative and Apoptotic Effects of Dendrosomal Farnesiferol C on Gastric Cancer Cells. Aas, Z; Babaei, E; Dehghan, G; Hosseinpour Feizi, MA, 2015) | 2.11 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " However, the low bioavailability of farnesiferol C limits its therapeutic potential." | ( Anti-proliferative and Apoptotic Effects of Dendrosomal Farnesiferol C on Gastric Cancer Cells. Aas, Z; Babaei, E; Dehghan, G; Hosseinpour Feizi, MA, 2015) | 0.94 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " dosage of 1 mg/kg body weight without any negative effect on the weight of the host mice." | ( Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades. Ahn, KS; Bae, H; Choi, S; Kim, KH; Kim, SH; Lee, EO; Lee, HJ; Lee, JH; Lee, Y; Lü, J; Ryu, SY, 2010) | 0.71 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Squalene--hopene cyclase | Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | IC50 (µMol) | 7.0000 | 0.0600 | 3.5300 | 7.0000 | AID204671 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID204671 | Inhibitory activity against squalene hopene cyclase from Alicyclobacillus acidocaldarius expressed in Escherichia coli | 2004 | Bioorganic & medicinal chemistry letters, Apr-19, Volume: 14, Issue:8 | Farnesyloxycoumarins, a new class of squalene-hopene cyclase inhibitors. |
| AID471279 | Antiviral activity against Influenza A virus H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect after 3 days by XTT assay | 2009 | Journal of natural products, Sep, Volume: 72, Issue:9 | Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 10 (76.92) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.30) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (7.69%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 12 (92.31%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||