Page last updated: 2024-11-13
eldeline
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
eldeline: Aconitum alkaloid; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Aconitum | genus | A plant genus of the family RANUNCULACEAE. Members contain a number of diterpenoid alkaloids including: aconitans, hypaconitine, ACONITINE, jesaconitine, ignavine, napelline, and mesaconitine. The common name of Wolfbane is similar to the common name for ARNICA.[MeSH] | Ranunculaceae | The buttercup plant family of the order RANUNCULALES, class MAGNOLIOPSIDA. The leaves are usually alternate and stalkless. The flowers usually have two to five free sepals and may be radially symmetrical or irregular.[MeSH] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 92854547 |
| MeSH ID | M0306225 |
Synonyms (8)
| Synonym |
|---|
| eldelin |
| eldeline |
| deltamine 6-acetate |
| deltaline |
| 6836-11-9 |
| 6beta,10-dihydroxy-1alpha,14alpha,16beta-trimethoxy-4-methyl-7beta,8-(methylenedioxy)- 20-ethylaconitan-6-yl acetate |
| AKOS037514617 |
| DTXSID40896808 |
Research Excerpts
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| " The results from this study indicate that the toxic alkaloids in larkspurs undergo flip-flop kinetics, meaning the rate of absorption of the alkaloids is slower than the rate of elimination." | ( Serum toxicokinetics after intravenous and oral dosing of larkspur toxins in goats. Gardner, DR; Green, BT; Pfister, JA; Stonecipher, CA; Welch, KD, 2017) | 0.46 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, those studies were all performed by orally dosing plant material." | ( Serum toxicokinetics after intravenous and oral dosing of larkspur toxins in goats. Gardner, DR; Green, BT; Pfister, JA; Stonecipher, CA; Welch, KD, 2017) | 0.46 |
| " Clinical signs of intoxication, including muscle coordination and function, were measured 24 h after oral dosing with larkspur by walking the cattle at a pace of 5 to 6 km h-1 for up to 40 min on an oval dirt track." | ( Sex-dependent differences for larkspur (Delphinium barbeyi) toxicosis in yearling Angus cattle1. Bennett, GL; Cook, D; Davis, TZ; Gardner, DR; Green, BT; Keele, JW; Lee, ST; Pfister, JA; Stegelmeier, BL; Stonecipher, CA; Welch, KD, 2019) | 0.51 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (13)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 10 (76.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.48
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.48) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||