dt 5461 has been researched along with lipid a in 13 studies
| Studies (dt 5461) | Trials (dt 5461) | Recent Studies (post-2010) (dt 5461) | Studies (lipid a) | Trials (lipid a) | Recent Studies (post-2010) (lipid a) |
|---|---|---|---|---|---|
| 16 | 0 | 0 | 3,901 | 125 | 1,143 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumazawa, E; Kusama, T; Osada, Y; Soga, T; Tohgo, A | 1 |
| Azuma, I; Hasegawa, A; Igarashi, Y; Kiso, M; Saiki, I; Sato, K; Yoo, YC | 1 |
| Azuma, I; Choon Yoo, Y; Fujihara, M; Hata, K; Sato, K; Sekiguchi, S; Suzuki, T; Takahashi, TA; Tono-Oka, S | 1 |
| Akimoto, T; Joto, N; Someya, K; Tohgo, A | 1 |
| Azuma, I; Mochizuki, M; Saiki, I; Sato, K; Takahashi, TA; Yoo, YC | 1 |
| Akimoto, T; Jimbo, T; Joto, N; Kita, Y; Kumazawa, E; Tohgo, A | 1 |
| Azuma, I; Fujihara, M; Fukushima, A; Saiki, I; Sato, K; Takahashi, TA; Tono-Oka, S; Yoo, YC | 1 |
| Akimoto, T; Jimbo, T; Tohgo, A | 1 |
| Akimoto, T; Jimbo, T; Joto, N; Kumazawa, E; Tohgo, A | 2 |
| Akahane, K; Akimoto, T; Someya, K; Tohgo, A; Tsutomi, Y | 1 |
| Nakano, M; Onozuka, K; Osada, Y; Shimada, S; Yamasu, H | 1 |
| Furuhama, K; Sagara-Ishijima, N | 1 |
13 other study(ies) available for dt 5461 and lipid a
| Article | Year |
|---|---|
Significant antitumor effect of a synthetic lipid A analogue, DT-5461, on murine syngeneic tumor models.
Topics: Animals; Antineoplastic Agents; Ascites; Bone Marrow; Disaccharides; Lipid A; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Picibanil; Tumor Cells, Cultured | 1992 |
DT-5461, a new synthetic lipid A analogue, inhibits lung and liver metastasis of tumor in mice.
Topics: Animals; Antineoplastic Agents; Carbohydrate Sequence; Disaccharides; Drug Administration Routes; Drug Administration Schedule; Female; Lipid A; Liver Neoplasms, Experimental; Lung Neoplasms; Lymphoma; Male; Melanoma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Sequence Data; Neoplasm Transplantation | 1992 |
Endotoxin antagonism by a synthetic lipid A analogue, DT-5461, with low endotoxicity in human peripheral blood monocytes.
Topics: Adjuvants, Immunologic; Binding, Competitive; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Disaccharides; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Humans; Interleukin-1; Kinetics; Lipid A; Lipopolysaccharides; Monocytes; Tumor Necrosis Factor-alpha | 1995 |
Production of tumor necrosis factor induced by synthetic low-toxicity lipid A analog, DT-5461a, is mediated by LPS receptor sites and tyrosine kinase-MAP kinase signaling pathway in murine macrophages.
Topics: Animals; Benzoquinones; Binding, Competitive; Blotting, Western; Cell Line, Transformed; Disaccharides; Lactams, Macrocyclic; Lipid A; Lipopolysaccharide Receptors; Lipopolysaccharides; Macrophages; Mice; Protein Kinases; Protein-Tyrosine Kinases; Quinones; Receptors, Immunologic; Rifabutin; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 1995 |
Inhibition of tumor-induced angiogenesis by a synthetic lipid A analogue with low endotoxicity, DT-5461.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Cell Division; Disaccharides; Endothelium, Vascular; Female; Lipid A; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Neovascularization, Pathologic; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Intratumoral production of tumor necrosis factor augmented by endogenous interferons results in potent antitumor effects of DT-5461, a synthetic lipid A analog.
Topics: Animals; Antineoplastic Agents; Disaccharides; Drug Administration Schedule; Interferons; Lipid A; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; RNA, Messenger; Tumor Necrosis Factor-alpha | 1995 |
A novel synthetic lipid A analog with low endotoxicity, DT-5461, prevents lethal endotoxemia.
Topics: Animals; Disaccharides; Female; Galactosamine; Humans; In Vitro Techniques; Interleukin-1; Lipid A; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Monocytes; Shock, Septic; Tumor Necrosis Factor-alpha | 1995 |
Effect of combined administration of a synthetic low-toxicity lipid A derivative, DT-5461a, and indomethacin in various experimental tumor models of colon 26 carcinoma in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dinoprostone; Disaccharides; Drug Screening Assays, Antitumor; Indomethacin; Lipid A; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Peritoneal Neoplasms; Tumor Necrosis Factor-alpha | 1995 |
Antitumor effect of DT-5461a, a synthetic low-toxicity lipid A analog, involves endogenous tumor necrosis factor induction subsequent to macrophage activation.
Topics: Animals; Antineoplastic Agents; Carbohydrate Sequence; Cytotoxicity Tests, Immunologic; Disaccharides; Fibrosarcoma; Lipid A; Macrophage Activation; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neoplasm Transplantation; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1994 |
Antitumor synthetic lipid A analog DT-5461a upregulates cytokine expression in a murine macrophage cell line through LPS pathway.
Topics: Animals; Binding Sites; Cell Line; Cytokines; Disaccharides; Dose-Response Relationship, Drug; Granulocyte-Macrophage Colony-Stimulating Factor; Lipid A; Lipopolysaccharides; Macrophages; Mice; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha; Up-Regulation | 1994 |
Non-specific resistance induced by a low-toxic lipid A analogue, DT-5461, in murine salmonellosis.
Topics: Adjuvants, Immunologic; Animals; Disaccharides; Exudates and Transudates; Female; Immunity, Innate; Interferon-gamma; Lipid A; Male; Mice; Mice, Inbred C3H; Phagocytosis; Salmonella Infections, Animal | 1993 |
Antitumor effect of DT-5461, a lipid A derivative, against human tumor xenografts is mediated by intratumoral production of tumor necrosis factor and affected by host immunosuppressive factors in nude mice.
Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Dinoprostone; Disaccharides; Drug Screening Assays, Antitumor; Fibrosarcoma; Humans; Lipid A; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Neoplasm Transplantation; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Toxic characteristics of the synthetic lipid A derivative DT-5461 in rats and monkeys.
Topics: Animals; Disaccharides; Disseminated Intravascular Coagulation; Hyperplasia; Lipid A; Lipopolysaccharides; Male; Rats; Rats, Sprague-Dawley; Saimiri; Species Specificity; Splenomegaly; Survival Rate | 1999 |