Target type: molecularfunction
Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]
Phosphatidylcholine transfer activity is a molecular function that describes the ability of enzymes to facilitate the movement of phosphatidylcholine (PC) molecules between different cellular compartments or membranes. PC is a major phospholipid component of cell membranes, playing critical roles in maintaining membrane structure, fluidity, and signal transduction.
Phosphatidylcholine transfer proteins (PCTPs) are a family of enzymes that specifically bind and transfer PC molecules. These proteins often exhibit substrate specificity, meaning they preferentially transfer certain types of PC molecules based on the fatty acid chains attached to the glycerol backbone.
The transfer process typically involves several steps:
1. **Binding:** The PCTP binds to a PC molecule in the donor membrane.
2. **Extraction:** The PCTP extracts the PC molecule from the donor membrane.
3. **Translocation:** The PCTP carries the PC molecule through the aqueous environment of the cell.
4. **Insertion:** The PCTP inserts the PC molecule into the acceptor membrane.
The transfer of PC molecules by PCTPs is crucial for several cellular processes, including:
* **Membrane biogenesis:** PCTPs contribute to the formation and maintenance of cellular membranes by facilitating the movement of PC molecules to different locations.
* **Lipid homeostasis:** PCTPs help regulate the lipid composition of membranes by transferring PC molecules between different compartments.
* **Signal transduction:** PC molecules can act as signaling molecules, and PCTPs can modulate these signaling pathways by transferring PC molecules to specific receptors or effectors.
* **Cellular trafficking:** PCTPs play a role in the transport of lipids and other molecules between different organelles.
Overall, phosphatidylcholine transfer activity is an essential molecular function that allows cells to maintain their membrane structure and function, regulate lipid homeostasis, and participate in various cellular signaling processes.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Microsomal triglyceride transfer protein large subunit | A microsomal triglyceride transfer protein large subunit that is encoded in the genome of human. [PRO:HJD, UniProtKB:P55157] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| nevirapine | nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection. Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS. | cyclopropanes; dipyridodiazepine | antiviral drug; HIV-1 reverse transcriptase inhibitor |
| efavirenz | efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection. efavirenz: HIV-1 reverse transcriptase inhibitor | acetylenic compound; benzoxazine; cyclopropanes; organochlorine compound; organofluorine compound | antiviral drug; HIV-1 reverse transcriptase inhibitor |
| bms201038 | BMS201038: an anticholesteremic agent and microsomal triglycide transfer protein inhibitor lomitapide : A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. | (trifluoromethyl)benzenes; benzamides; fluorenes; piperidines | anticholesteremic drug; MTP inhibitor |
| dirlotapide | dirlotapide: structure in first source | ||
| jnj-31020028 |