Target type: molecularfunction
Enables the directed movement of lipids into, out of or within a cell, or between cells. [GOC:ai]
Lipid transporter activity is a crucial molecular function that enables the movement of lipids, a diverse group of hydrophobic molecules, across cellular membranes. This process is essential for various cellular functions, including:
* **Membrane biogenesis and maintenance:** Lipids are fundamental building blocks of cellular membranes, providing structural integrity and fluidity. Lipid transporters ensure the appropriate composition and distribution of lipids within the membrane.
* **Energy storage and utilization:** Lipids serve as a primary source of energy. Lipid transporters facilitate the uptake and delivery of fatty acids and other lipids to metabolic pathways where they are broken down for energy production.
* **Signal transduction:** Some lipids act as signaling molecules, mediating cellular responses to external stimuli. Lipid transporters regulate the levels of these signaling lipids, influencing cell growth, differentiation, and other processes.
* **Cellular trafficking:** Lipids are transported between different organelles within the cell, enabling the delivery of essential molecules to their specific destinations.
* **Hormone synthesis and transport:** Steroid hormones, which are synthesized from lipids, are transported throughout the body by lipid transporters, regulating various physiological functions.
Lipid transporters exhibit diverse mechanisms of action. Some transporters actively pump lipids against their concentration gradient, requiring energy. Others utilize passive diffusion, relying on the concentration gradient to drive the movement of lipids.
The specific type of lipid transported varies widely, ranging from simple fatty acids to complex phospholipids and sterols. The selectivity of lipid transporters ensures the accurate delivery of lipids to their target locations.
Mutations or dysregulation of lipid transporter activity can lead to various pathological conditions, including metabolic disorders, neurological diseases, and cancer. Therefore, understanding the molecular function of lipid transporter activity is essential for developing effective therapies for these conditions.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Microsomal triglyceride transfer protein large subunit | A microsomal triglyceride transfer protein large subunit that is encoded in the genome of human. [PRO:HJD, UniProtKB:P55157] | Homo sapiens (human) |
| Solute carrier organic anion transporter family member 2A1 | A solute carrier organic anion transporter family member 2A1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q92959] | Homo sapiens (human) |
| Microsomal triglyceride transfer protein large subunit | A microsomal triglyceride transfer protein large subunit that is encoded in the genome of human. [PRO:HJD, UniProtKB:P55157] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| phosphoenolpyruvate | phosphoenolpyruvate : A monocarboxylic acid anion resuting from selective deprotonation of the carboxy group of phosphoenolpyruvic acid. Phosphoenolpyruvate: A monocarboxylic acid anion derived from selective deprotonation of the carboxy group of phosphoenolpyruvic acid. It is a metabolic intermediate in GLYCOLYSIS; GLUCONEOGENESIS; and other pathways. phosphoenolpyruvic acid : A monocarboxylic acid that is acrylic acid substituted by a phosphonooxy group at position 2. It is a metabolic intermediate in pathways like glycolysis and gluconeogenesis. | carboxyalkyl phosphate; monocarboxylic acid | fundamental metabolite |
| pyruvic acid | pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis. Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed) | 2-oxo monocarboxylic acid | cofactor; fundamental metabolite |
| nevirapine | nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection. Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS. | cyclopropanes; dipyridodiazepine | antiviral drug; HIV-1 reverse transcriptase inhibitor |
| d-lactic acid | (R)-lactic acid : An optically active form of lactic acid having (R)-configuration. | 2-hydroxypropanoic acid | Escherichia coli metabolite; human metabolite |
| efavirenz | efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection. efavirenz: HIV-1 reverse transcriptase inhibitor | acetylenic compound; benzoxazine; cyclopropanes; organochlorine compound; organofluorine compound | antiviral drug; HIV-1 reverse transcriptase inhibitor |
| glyceraldehyde 3-phosphate | glyceraldehyde 3-phosphate : An aldotriose phosphate that is the 3-phospho derivative of glyceraldehyde. It is an important metabolic intermediate in several central metabolic pathways in all organisms. Glyceraldehyde 3-Phosphate: An aldotriose which is an important intermediate in glycolysis and in tryptophan biosynthesis. | glyceraldehyde 3-phosphate | mouse metabolite |
| alpha-D-fructofuranose 1,6-bisphosphate | alpha-D-fructofuranose 1,6-bisphosphate : A D-fructofuranose 1,6-bisphosphate with an alpha-configuration at the anomeric position. | D-fructofuranose 1,6-bisphosphate | |
| prostaglandin d2 | prostaglandin D2 : A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- stereoisomer). Prostaglandin D2: The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects. | prostaglandins D | human metabolite; mouse metabolite |
| dinoprostone | prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins. | prostaglandins E | human metabolite; mouse metabolite; oxytocic |
| dinoprost | Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions. prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor. | monocarboxylic acid; prostaglandins Falpha | human metabolite; mouse metabolite |
| alprostadil | prostaglandins E | anticoagulant; human metabolite; platelet aggregation inhibitor; vasodilator agent | |
| thromboxane b2 | thromboxane B2 : A member of the class of thromboxanes B that is (5Z,13E)-thromboxa-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. Thromboxane B2: A stable, physiologically active compound formed in vivo from the prostaglandin endoperoxides. It is important in the platelet-release reaction (release of ADP and serotonin). | thromboxanes B | human metabolite; mouse metabolite |
| latanoprost | latanoprost : A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension. Latanoprost: A prostaglandin F analog used to treat OCULAR HYPERTENSION in patients with GLAUCOMA. | isopropyl ester; prostaglandins Falpha; triol | antiglaucoma drug; antihypertensive agent; EC 4.2.1.1 (carbonic anhydrase) inhibitor; prodrug |
| phxa 85 | PhXa 85: RN given for (1R-(1alpha(Z),2beta(R*),3alpha,5alpha))-isomer | hydroxy monocarboxylic acid; prostaglandins Falpha | antiglaucoma drug; antihypertensive agent; EC 4.2.1.1 (carbonic anhydrase) inhibitor |
| bms201038 | BMS201038: an anticholesteremic agent and microsomal triglycide transfer protein inhibitor lomitapide : A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. | (trifluoromethyl)benzenes; benzamides; fluorenes; piperidines | anticholesteremic drug; MTP inhibitor |
| dirlotapide | dirlotapide: structure in first source | ||
| jnj-31020028 |