Target type: molecularfunction
Removes phosphatidylethanolamine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GO_REF:0000066, GOC:TermGenie, PMID:8606365]
Phosphatidylethanolamine transfer activity refers to the enzymatic process of moving phosphatidylethanolamine (PE) molecules from one lipid bilayer to another. PE is a phospholipid that plays a crucial role in various cellular processes, including membrane structure, signal transduction, and lipid metabolism.
**Key Molecular Functions:**
* **Membrane Remodeling and Maintenance:** PE transfer enzymes, also known as phospholipid translocases, contribute to the dynamic remodeling of cell membranes. They ensure the appropriate distribution of PE between different membrane compartments, affecting membrane fluidity, curvature, and protein interactions.
* **Signal Transduction:** PE is involved in diverse signaling pathways. PE transfer activity can influence the localization and function of signaling molecules by altering the membrane composition and creating specific microdomains.
* **Lipid Metabolism:** PE is a precursor for other lipids, such as phosphatidylcholine and cardiolipin. PE transfer enzymes play a role in regulating the synthesis and turnover of these lipids.
**Mechanisms of Action:**
* **Translocation across Bilayers:** PE transferases typically move PE molecules across membrane bilayers by utilizing energy derived from the electrochemical gradient of protons or other ions.
* **Specific Protein Interactions:** These enzymes often exhibit specificity for certain membrane proteins or lipid domains, contributing to the targeted movement of PE.
**Examples:**
* **P4-ATPase:** This family of phospholipid flippases translocates PE from the outer leaflet to the inner leaflet of the plasma membrane.
* **Sec14p:** In yeast, Sec14p acts as a PE transfer protein, involved in vesicle trafficking and lipid metabolism.
Overall, phosphatidylethanolamine transfer activity is a fundamental process that governs the distribution and function of PE, impacting essential cellular processes like membrane structure, signal transduction, and lipid metabolism.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Microsomal triglyceride transfer protein large subunit | A microsomal triglyceride transfer protein large subunit that is encoded in the genome of human. [PRO:HJD, UniProtKB:P55157] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| nevirapine | nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection. Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS. | cyclopropanes; dipyridodiazepine | antiviral drug; HIV-1 reverse transcriptase inhibitor |
| efavirenz | efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection. efavirenz: HIV-1 reverse transcriptase inhibitor | acetylenic compound; benzoxazine; cyclopropanes; organochlorine compound; organofluorine compound | antiviral drug; HIV-1 reverse transcriptase inhibitor |
| bms201038 | BMS201038: an anticholesteremic agent and microsomal triglycide transfer protein inhibitor lomitapide : A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. | (trifluoromethyl)benzenes; benzamides; fluorenes; piperidines | anticholesteremic drug; MTP inhibitor |
| dirlotapide | dirlotapide: structure in first source | ||
| jnj-31020028 |