ceramide 1-phosphate transfer activity
Definition
Target type: molecularfunction
Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:TermGenie, PMID:23863933]
Ceramide 1-phosphate transferase (CPT) activity is a crucial enzymatic function involved in the biosynthesis of ceramide 1-phosphate (C1P), a bioactive sphingolipid with diverse roles in cellular signaling and regulation. This enzyme catalyzes the transfer of a phosphate group from a donor molecule, typically ATP, to the 1-hydroxyl group of ceramide, forming C1P. The reaction occurs in the endoplasmic reticulum and Golgi apparatus, where CPTs are localized. C1P production is tightly regulated, influenced by various factors including intracellular levels of ceramide, ATP, and calcium ions. The molecular mechanism of CPT activity involves the interaction of the enzyme with both ceramide and ATP. The enzyme binds to ceramide through its hydrophobic domain, while the phosphate group of ATP is transferred to the 1-hydroxyl group of ceramide through a nucleophilic attack facilitated by the enzyme's catalytic residues. This enzymatic activity is crucial for maintaining cellular homeostasis, playing a role in a variety of cellular processes, including cell growth, survival, differentiation, apoptosis, and inflammation. Its dysregulation is associated with various diseases, including cancer, cardiovascular disease, and neurodegenerative disorders. C1P acts as a signaling molecule by interacting with various cellular receptors, triggering downstream signaling pathways that ultimately lead to the regulation of cellular functions.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Microsomal triglyceride transfer protein large subunit | A microsomal triglyceride transfer protein large subunit that is encoded in the genome of human. [PRO:HJD, UniProtKB:P55157] | Homo sapiens (human) |
Compounds (5)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| nevirapine | nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection. Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS. | cyclopropanes; dipyridodiazepine | antiviral drug; HIV-1 reverse transcriptase inhibitor |
| efavirenz | efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection. efavirenz: HIV-1 reverse transcriptase inhibitor | acetylenic compound; benzoxazine; cyclopropanes; organochlorine compound; organofluorine compound | antiviral drug; HIV-1 reverse transcriptase inhibitor |
| bms201038 | BMS201038: an anticholesteremic agent and microsomal triglycide transfer protein inhibitor lomitapide : A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. | (trifluoromethyl)benzenes; benzamides; fluorenes; piperidines | anticholesteremic drug; MTP inhibitor |
| dirlotapide | dirlotapide: structure in first source | ||
| jnj-31020028 |