Target type: molecularfunction
Directly binding to a triglyceride and delivering it either to an acceptor molecule or to a specific location. [PMID:23475612]
Triglyceride transfer activity is a crucial molecular function involved in the movement of triglycerides between various cellular compartments and across different tissues. Triglycerides, also known as fats, are essential for energy storage, cell membrane structure, and signaling pathways. The process of triglyceride transfer involves specific proteins, known as triglyceride transfer proteins (TTPs), which facilitate the transport of triglycerides from one lipid-containing particle to another. These proteins act as molecular chaperones, recognizing and binding to triglycerides and delivering them to their target destinations. This transfer activity is crucial for various cellular processes, including:
- **Lipid metabolism and energy storage:** TTPs play a vital role in the assembly and secretion of very-low-density lipoproteins (VLDL), the primary carriers of triglycerides from the liver to other tissues. They also facilitate the transfer of triglycerides from dietary lipids to chylomicrons, which transport fats from the small intestine to the bloodstream.
- **Cellular membrane composition:** TTPs are involved in the transport of triglycerides to various cellular membranes, including the plasma membrane, endoplasmic reticulum, and Golgi apparatus. This transfer is essential for maintaining membrane fluidity and integrity.
- **Signal transduction:** Triglycerides can act as signaling molecules, and TTPs are involved in their delivery to target receptors, mediating various cellular responses.
- **Atherosclerosis:** Dysregulation of triglyceride transfer activity has been implicated in the development of atherosclerosis, a condition characterized by the buildup of plaque in arteries. Increased triglyceride levels and reduced TTP activity can contribute to the formation of atherosclerotic lesions.
- **Other disease states:** Altered triglyceride transfer activity has been linked to various other disease states, including diabetes, obesity, and liver disease.
The molecular mechanisms underlying triglyceride transfer activity are complex and involve a series of interactions between TTPs, triglycerides, and other lipid-binding proteins. Understanding these mechanisms is essential for developing novel therapeutic strategies for lipid-related disorders.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Microsomal triglyceride transfer protein large subunit | A microsomal triglyceride transfer protein large subunit that is encoded in the genome of human. [PRO:HJD, UniProtKB:P55157] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| nevirapine | nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection. Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS. | cyclopropanes; dipyridodiazepine | antiviral drug; HIV-1 reverse transcriptase inhibitor |
| efavirenz | efavirenz : 1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection. efavirenz: HIV-1 reverse transcriptase inhibitor | acetylenic compound; benzoxazine; cyclopropanes; organochlorine compound; organofluorine compound | antiviral drug; HIV-1 reverse transcriptase inhibitor |
| bms201038 | BMS201038: an anticholesteremic agent and microsomal triglycide transfer protein inhibitor lomitapide : A member of the class of benzamides obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. | (trifluoromethyl)benzenes; benzamides; fluorenes; piperidines | anticholesteremic drug; MTP inhibitor |
| dirlotapide | dirlotapide: structure in first source | ||
| jnj-31020028 |