Page last updated: 2024-11-09

diphenylthiohydantoin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

diphenylthiohydantoin: was MH 1975-92 (see under PHENYTOIN 1975-90); use PHENYTOIN to search DIPHENYLTHIOHYDANTOIN 1975-92; an inducer of microsomal drug-metabolizing enzymes [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID854150
CHEMBL ID301920
SCHEMBL ID1685397
MeSH IDM0198334

Synonyms (46)

Synonym
5,5-diphenyl-2-sulfanylideneimidazolidin-4-one
brn 0229988
nsc 82311
einecs 244-201-3
ai3-52493
hydantoin, 5,5-diphenyl-2-thio-
OPREA1_715171
5,5-diphenyl-2-thioxo-imidazolidin-4-one
diphenylthiohydantoin
nsc-82311
5,5-diphenylthiohydantoin
dpth
nsc82311
mls002694486 ,
hydantoin,5-diphenyl-2-thio-
4-imidazolidinone,5-diphenyl-2-thioxo-
21083-47-6
inchi=1/c15h12n2os/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10h,(h2,16,17,18,19
5,5-diphenyl-2-thioxoimidazolidin-4-one
5,5-diphenyl-2-thiohydantoin
4-imidazolidinone, 5,5-diphenyl-2-thioxo-
5,5-diphenyl-2-thiohydantoin, 99%
STK396898
smr001560414
AKOS000478644
thiophenytoin
CHEMBL301920
HMS3089K14
5,5-diphenyl-2-sulfanylidene-4-imidazolidinone
A815127
5,5-diphenyl-2-sulfanylidene-imidazolidin-4-one
5-24-08-00403 (beilstein handbook reference)
13y6zc0yr8 ,
unii-13y6zc0yr8
5,5-diphenyl-2-thioxo-4-imidazolidinone
AG-670/03142062
5,5-diphenylimidazolidine-4-one-2-thione
FT-0638088
bdbm50422753
DTXSID9066677
SCHEMBL1685397
5,5-diphenyl-2-thioxo-4-imidazolidinone #
J-013831
5,5-diphenyl-2-thioimidazolidine-4-one
Q27251552
WAA08347

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" In the N3 nitrogen-substituted series one compound, 5,5-diphenyl-N3-n-butyl-2-thiohydantoin, DPBTH (7), showed promise during initial screening, but when analyzed in a dose-response study, its activity was considerably less than that of the parent compound DPTH."( 5,5-Diaryl-2-thiohydantoins and 5,5-diaryl-N3-substituted-2-thiohydantoins as potential hypolipidemic agents.
Tompkins, JE, 1986
)
0.27
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
chromobox protein homolog 1Homo sapiens (human)Potency100.00000.006026.168889.1251AID540317
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.12510.050127.073689.1251AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (23)

Assay IDTitleYearJournalArticle
AID259070Displacement of [3H]SR141716A from human CB1 expressed in CHO cells at 10 uM2006Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates.
AID259069Inhibitory activity against FAAH in Wistar rat brain homogenate2006Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates.
AID185866Compound was tested for hypolipidemic activity in male Sprague-Dawley rats by measuring amount of liver cholesterol after administration of 600 mg dose per kg of diet1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
5,5-Diaryl-2-thiohydantoins and 5,5-diaryl-N3-substituted-2-thiohydantoins as potential hypolipidemic agents.
AID187081The concentration required to reduce liver cholesterol half-way from the average orotic acid level to the basal level1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
5,5-Diaryl-2-thiohydantoins and 5,5-diaryl-N3-substituted-2-thiohydantoins as potential hypolipidemic agents.
AID187082The concentration required to reduce liver triglyceride half-way from the average orotic acid level to the basal level1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
5,5-Diaryl-2-thiohydantoins and 5,5-diaryl-N3-substituted-2-thiohydantoins as potential hypolipidemic agents.
AID189703The activity relative to DPTH in liver triglyceride1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
5,5-Diaryl-2-thiohydantoins and 5,5-diaryl-N3-substituted-2-thiohydantoins as potential hypolipidemic agents.
AID259072Displacement of [3H]CP-55940 from human CB2 expressed in CHO cells at 10 uM2006Journal of medicinal chemistry, Jan-12, Volume: 49, Issue:1
Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates.
AID189702The activity relative to DPTH in liver cholesterol1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
5,5-Diaryl-2-thiohydantoins and 5,5-diaryl-N3-substituted-2-thiohydantoins as potential hypolipidemic agents.
AID185855Compound was tested for hypolipidemic activity in male Sprague-Dawley rats by measuring amount of liver triglyceride after administration of 600 mg dose per kg of diet1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
5,5-Diaryl-2-thiohydantoins and 5,5-diaryl-N3-substituted-2-thiohydantoins as potential hypolipidemic agents.
AID114124Anticonvulsant activity was measured from scMET test by delivering the drug intraperitoneally after 0.5 hr1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Synthesis and anticonvulsant activity of 2-iminohydantoins.
AID114123Anticonvulsant activity was measured from mES test by delivering the drug intraperitoneally after 0.5 hr; NA-Not active1991Journal of medicinal chemistry, Jun, Volume: 34, Issue:6
Synthesis and anticonvulsant activity of 2-iminohydantoins.
AID171184Compound was tested for hypolipidemic activity in male Sprague-Dawley rats by measuring change in body weight after administration of 600 mg dose per kg of diet1986Journal of medicinal chemistry, May, Volume: 29, Issue:5
5,5-Diaryl-2-thiohydantoins and 5,5-diaryl-N3-substituted-2-thiohydantoins as potential hypolipidemic agents.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (23.08)18.7374
1990's2 (15.38)18.2507
2000's3 (23.08)29.6817
2010's4 (30.77)24.3611
2020's1 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.87 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.58 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]