Page last updated: 2024-12-11
diethoxyphosphoryloxymethyl butanoate
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
diethoxyphosphoryloxymethyl butanoate: butyroyloxymethyl-diethyl phosphate antitumor cpd; structure in first source; do not confuse with AN 7 peptide complex [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 9837935 |
| CHEMBL ID | 486366 |
| SCHEMBL ID | 7781266 |
| MeSH ID | M0487562 |
Synonyms (9)
| Synonym |
|---|
| butyroyloxymethyl-diethyl phosphate |
| butyroyloxymethyl diethylphosphate |
| diethoxyphosphoryloxymethyl butanoate |
| (diethoxyphosphoryloxy)methyl butyrate |
| CHEMBL486366 |
| butanoic acid, [(diethoxyphosphinyl)oxy]methyl ester |
| 213262-83-0 |
| SCHEMBL7781266 |
| DTXSID60431619 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (4)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID347407 | Increase in protoporphyrin 9 levels in human U251 cells at 200 uM after 24 hrs relative to control | 2008 | Journal of medicinal chemistry, Dec-11, Volume: 51, Issue:23 | Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. |
| AID347392 | Cytotoxicity against human U251 cells after 72 hrs by Hoechst test | 2008 | Journal of medicinal chemistry, Dec-11, Volume: 51, Issue:23 | Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. |
| AID347414 | Inhibition of 26S proteasome activity in human U251 cells at 100 uM after 24 hrs relative to control | 2008 | Journal of medicinal chemistry, Dec-11, Volume: 51, Issue:23 | Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. |
| AID347399 | Increase in ROS production in human U251 cells at 50 uM after 4 hrs by FACS flow cytometry in presence of N-acetyl-L-cysteine | 2008 | Journal of medicinal chemistry, Dec-11, Volume: 51, Issue:23 | Novel multifunctional acyloxyalkyl ester prodrugs of 5-aminolevulinic acid display improved anticancer activity independent and dependent on photoactivation. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (12)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 11.87
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.87) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 13 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||