epothilone C: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
epothilone C : An epothilone that is 1-oxacyclohexadec-13-ene-2,6-dione which is substituted by hydroxy groups at positions 4 and 9, methyl groups at positions 5, 5, 7, and 9, and by a (1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl group at position 16 (the 4S,7R,8S,9S,13Z,16S stereoisomer). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 9891226 |
| CHEMBL ID | 319648 |
| CHEBI ID | 80029 |
| SCHEMBL ID | 4870 |
| MeSH ID | M0287227 |
| Synonym |
|---|
| epothilone c |
| chebi:80029 , |
| CHEMBL319648 |
| BEFZAMRWPCMWFJ-QJKGZULSSA-N |
| SCHEMBL4870 |
| (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-5,5,7,9-tetramethyl-16-[(1e)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]oxacyclohexadec-13-ene-2,6-dione |
| 2570948-91-1 |
| epo c |
| (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-5,5,7,9-tetramethyl-16-((1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione |
| epothilone c [who-dd] |
| oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9-tetramethyl-16-((1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)-, (4s,7r,8s,9s,13z,16s)- |
| desoxyepothilone a |
| (-)-desoxyepothilone a |
| 18T00XLN7E , |
| (-)-deoxyepothilone a |
| 186692-73-9 |
| unii-18t00xln7e |
| Q27149174 |
| oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9-tetramethyl-16-(1e)-1-methyl-2-(2-methyl-4-t |
| (4s,7r,8s,9s,13z,16s)-4,8-dihydroxy-5,5,7,9-tetramethyl-16-[(e)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-1-oxacyclohexadec-13-ene-2,6-dione |
| EX-A5464 |
| oxacyclohexadec-13-ene-2,6-dione,4,8-dihydroxy-5,5,7,9-tetramethyl-16-(1e)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-,(4s,7r,8s,9s,13z,16s)- |
| Class | Description |
|---|---|
| epothilone | Any member of the class of 16-membered macrolide natural products, or their analogues, normally containing a double bond or its epoxide at positions 12-13 and bearing hydroxy groups at positions 4 and 8, methyl groups at positions 5, 5, 7, and 9, an oxo group at position 6, and a 1-(2-substituted-1,3-thiazol-4-yl)prop-1-en-2-yl substituent at position 15. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID94561 | Compound was tested for cytotoxicity against L929 fibroblast cell lines in mouse | 1998 | Bioorganic & medicinal chemistry letters, Nov-03, Volume: 8, Issue:21 | Derivatization of the C12-C13 functional groups of epothilones A, B and C. |
| AID356493 | Cytotoxicity against human NCI-H460 cells after 3 days by SRB assay | 2003 | Journal of natural products, Oct, Volume: 66, Issue:10 | Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations. |
| AID356712 | Cytotoxicity against mouse L929 cells | 2001 | Journal of natural products, Jul, Volume: 64, Issue:7 | New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. |
| AID356492 | Cytotoxicity against human SF268 cells after 3 days by SRB assay | 2003 | Journal of natural products, Oct, Volume: 66, Issue:10 | Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations. |
| AID356491 | Cytotoxicity against human NCI/ADR cells after 3 days by SRB assay | 2003 | Journal of natural products, Oct, Volume: 66, Issue:10 | Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations. |
| AID356490 | Cytotoxicity against human MCF7 cells after 3 days by SRB assay | 2003 | Journal of natural products, Oct, Volume: 66, Issue:10 | Isolation and characterization of new epothilone analogues from recombinant Myxococcus xanthus fermentations. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 17 (77.27) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.61) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 3 (13.64%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 19 (86.36%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||