Compounds > epothilone e

Page last updated: 2024-08-02 08:13:10

epothilone e

Description

epothilone E: structure in first source [MeSH]

Cross-References

ID Source	ID
PubMed CID	9806341
CHEMBL ID	470478
SCHEMBL ID	4126
MeSH ID	M0334049

Synonyms (16)

Synonym
CHEMBL470478
epothilone e
FCCNKYGSMOSYPV-OKOHHBBGSA-N
SCHEMBL4126
AC-28332
201049-37-8
(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-[(e)-1-[2-(hydroxymethyl)-1,3-thiazol-4-yl]prop-1-en-2-yl]-8,8,10,12-tetramethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
EX-A5461
epothilon e
uk5h6yzz8a ,
4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione, 7,11-dihydroxy-3-((1e)-2-(2-(hydroxymethyl)-4-thiazolyl)-1-methylethenyl)-8,8,10,12-tetramethyl-, (1s,3s,7s,10r,11s,12s,16r)-
(-)-epothilone e
(1s,3s,7s,10r,11s,12s,16r)-7,11-dihydroxy-3-((1e)-2-(2-(hydroxymethyl)-4-thiazolyl)-1-methylethenyl)-8,8,10,12-tetramethyl-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione
unii-uk5h6yzz8a
CS-0565544
HY-147317

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID356712	Cytotoxicity against mouse L929 cells	2001	Journal of natural products, Jul, Volume: 64, Issue:7 ISSN: 0163-3864	New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (33.33)	18.2507
2000's	4 (66.67)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
desoxyepothilone b	1	epothilone	microtubule-stabilising agent	2001	2001	23.0	low	0	0	0	1	0	0
epothilone b	1	epothilone; epoxide	antineoplastic agent; apoptosis inducer; microtubule-stabilising agent	2001	2001	23.0	low	0	0	0	1	0	0
epothilone a	1	epothilone; epoxide	antineoplastic agent; metabolite; microtubule-stabilising agent; tubulin modulator	2001	2001	23.0	low	0	0	0	1	0	0
desoxyepothilone a	1	epothilone		2001	2001	23.0	low	0	0	0	1	0	0
epothilone f	1			2001	2001	23.0	high	0	0	0	1	0	0

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
verapamil	1	aromatic ether; nitrile; polyether; tertiary amino compound		2001	2001	23.0	low	0	0	0	1	0	0
cysteamine	1	amine; thiol	geroprotector; human metabolite; mouse metabolite; radiation protective agent	2006	2006	18.0	low	0	0	0	1	0	0
thiazoles	6	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		1999	2006	22.8	medium	0	0	2	4	0	0
paclitaxel	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent	2001	2001	23.0	low	0	0	0	1	0	0
desoxyepothilone b	4	epothilone	microtubule-stabilising agent	2001	2006	21.8	medium	0	0	0	4	0	0
epothilone b	4	epothilone; epoxide	antineoplastic agent; apoptosis inducer; microtubule-stabilising agent	1999	2001	23.5	medium	0	0	1	3	0	0
epothilone a	6	epothilone; epoxide	antineoplastic agent; metabolite; microtubule-stabilising agent; tubulin modulator	1999	2006	22.8	medium	0	0	2	4	0	0
desoxyepothilone a	3	epothilone		2001	2006	21.3	high	0	0	0	3	0	0
epothilone f	3			2001	2006	21.3	high	0	0	0	3	0	0

Condition	Indicated	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020