desoxyepothilone-a and Breast-Neoplasms

desoxyepothilone-a has been researched along with Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for desoxyepothilone-a and Breast-Neoplasms

Article	Year
Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells. Bioorganic & medicinal chemistry letters, 2008, Sep-01, Volume: 18, Issue:17 The total synthesis of C25-benzyloxy epothilone C is described. A sequential Suzuki-Aldol-Yamaguchi macrolactonization strategy was utilized employing a novel derivatized C8-C12 fragment. The C25-benzyloxy analog exhibited significantly reduced biological activity in microtubule assembly and cytotoxicity assays. Molecular modeling simulations indicated that excessive steric bulk in the C25 position may reduce activity by disrupting key hydrogen bonds that are crucial for epothilone binding to beta-tubulin. Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Epothilones; Humans; Hydrogen Bonding; Tubulin; Tubulin Modulators	2008

Article

Year

Total synthesis and evaluation of C25-benzyloxyepothilone C for tubulin assembly and cytotoxicity against MCF-7 breast cancer cells.

Bioorganic & medicinal chemistry letters, 2008, Sep-01, Volume: 18, Issue:17

The total synthesis of C25-benzyloxy epothilone C is described. A sequential Suzuki-Aldol-Yamaguchi macrolactonization strategy was utilized employing a novel derivatized C8-C12 fragment. The C25-benzyloxy analog exhibited significantly reduced biological activity in microtubule assembly and cytotoxicity assays. Molecular modeling simulations indicated that excessive steric bulk in the C25 position may reduce activity by disrupting key hydrogen bonds that are crucial for epothilone binding to beta-tubulin.

Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Epothilones; Humans; Hydrogen Bonding; Tubulin; Tubulin Modulators

2008