collismycin a

Description

collismycin A: glucocorticoid receptor antagonist; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	135482271
CHEMBL ID	1834105
SCHEMBL ID	2620994
MeSH ID	M0237633

Synonyms (15)

Synonym
ACON1_001720
CHEMBL1834105
(2,2'-bipyridine)-6-carboxaldehyde, 4-methoxy-5-(methylthio)-, oxime, (e)-
collismycin a
158792-24-6
sf 2738a
AKOS022174900
SCHEMBL2620994
(e)-4-methoxy-5-(methylthio)-[2,2'-bipyridine]-6-carbaldehyde oxime
4-methoxy-3-methylsulfanyl-2-(nitrosomethylene)-6-(2-pyridyl)-1h-pyridine
ncgc00180209-02!4-methoxy-3-methylsulfanyl-2-(nitrosomethylidene)-6-pyridin-2-yl-1h-pyridine [iin-based on: ccmslib00000848991]
ncgc00180209-02!4-methoxy-3-methylsulfanyl-2-(nitrosomethylidene)-6-pyridin-2-yl-1h-pyridine
(ne)-n-[(4-methoxy-3-methylsulfanyl-6-pyridin-2-ylpyridin-2-yl)methylidene]hydroxylamine
(e)-n-{[4-methoxy-5-(methylsulfanyl)-[2,2'-bipyridin]-6-yl]methylidene}hydroxylamine
[2,2'-bipyridine]-6-carboxaldehyde, 4-methoxy-5-(methylthio)-, oxime, [c(e)]-

Research Excerpts

Overview

Collismycin A is a member of the 2,2'-bipyridyl family of natural products. structurally belongs to the hybrid polyketides-nonribosomal peptides.

Excerpt	Reference
"Collismycin A is a member of the 2,2'-bipyridyl family of natural products and structurally belongs to the hybrid polyketides-nonribosomal peptides. "	( Generation by mutasynthesis of potential neuroprotectant derivatives of the bipyridyl collismycin A. Braña, AF; García, I; González-Sabín, J; Méndez, C; Morís, F; Salas, JA; Sialer, C, 2013)
"Collismycin A is a member of the 2,2'-bipyridyl family of natural products that shows cytotoxic activity. "	( Engineering the biosynthesis of the polyketide-nonribosomal peptide collismycin A for generation of analogs with neuroprotective activity. Braña, AF; Garcia, I; González-Sabín, J; Méndez, C; Moris, F; Rohr, J; Salas, JA; Vior, NM, 2013)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (11)

Assay ID	Title	Year	Journal	Article
AID621494	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation at 50 uM	2011	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19	Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
AID621488	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation	2011	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19	Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
AID621492	Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation at 50 uM	2011	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19	Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
AID621495	Cytotoxicity against human AGS cells assessed as inhibition of cell proliferation at 50 uM	2011	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19	Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
AID621487	Cytotoxicity against human HCT116 cells assessed as inhibition of cell proliferation	2011	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19	Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
AID621493	Cytotoxicity against human MCF7 cells assessed as inhibition of cell proliferation at 50 uM	2011	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19	Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
AID772966	Neuroprotective activity in 3 days postfertilized zebrafish larvae assessed as reduction of all-trans retinoic acid-induced apoptosis at 1 uM after 24 hrs by fluorescence microscopy	2013	Bioorganic & medicinal chemistry letters, Oct-15, Volume: 23, Issue:20	Generation by mutasynthesis of potential neuroprotectant derivatives of the bipyridyl collismycin A.
AID621489	Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation	2011	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19	Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
AID621490	Cytotoxicity against human AGS cells assessed as inhibition of cell proliferation	2011	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19	Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
AID621496	Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation at 50 uM	2011	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19	Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
AID621491	Cytotoxicity against human HepG2 cells assessed as inhibition of cell proliferation	2011	Bioorganic & medicinal chemistry letters, Oct-01, Volume: 21, Issue:19	Coprismycins A and B, neuroprotective phenylpyridines from the dung beetle-associated bacterium, Streptomyces sp.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (20.00)	18.2507
2000's	1 (10.00)	29.6817
2010's	6 (60.00)	24.3611
2020's	1 (10.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
picolinic acid picolinic acid: iron-chelating agent that inhibits DNA synthesis; may interfere with iron-dependent production of stable free organic radical which is essential for ribonucleotide reductase formation of deoxyribonucleotides; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7206. picolinic acid : A pyridinemonocarboxylic acid in which the carboxy group is located at position 2. It is an intermediate in the metabolism of tryptophan.	2.48	2	pyridinemonocarboxylic acid	human metabolite; MALDI matrix material
2,2'-dipyridyl 2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.	3.56	8	bipyridine	chelator; ferroptosis inhibitor
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.07	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
berlition berlition: antioxidant preparation containing alpha-lipoic acid, used in the neuroprotective therapy of chronic brain ischemia for correction of free-radical processes. (R)-lipoic acid : The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.. lipoic acid : A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.	2.08	1	dithiolanes; heterocyclic fatty acid; lipoic acid; thia fatty acid	cofactor; nutraceutical; prosthetic group
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.31	1	cysteinium	fundamental metabolite
collismycin b collismycin B: glucocorticoid receptor antagonist; structure in first source	2.95	4
cerulomycin cerulomycin: from Streptomyces caeruleus; structure given in first source; RN given refers to (E)-isomer. caerulomycin A : A pyridine alkaloid that is 2,2'-bipyridine substituted by a methoxy group at position 4 and a (E)-(hydroxyimino)methyl group at position 6. Isolated from the marine-derived actinomycete Actinoalloteichus cyanogriseus, it exhibits antineoplastic activity.	2.31	1	aldoxime; aromatic ether; bipyridines; pyridine alkaloid	antineoplastic agent; bacterial metabolite; marine metabolite

Condition	Relationship Strength	Studies
Encephalopathy, Toxic [description not available]	2.06	1
Autosomal Dominant Juvenile Parkinson Disease [description not available]	2.06	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	2.06	1
Parkinsonian Disorders A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.	2.06	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	1.98	1

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