collismycin-a and Parkinsonian-Disorders

Two new phenylpyridines, named coprismycins A and B (1 and 2), and previously reported dipyridines (3-6) were isolated from a culture of Streptomyces sp. associated with the dung beetle, Copris tripartitus. The structures of the coprismycins (1 and 2) were elucidated by the analysis of 1D and 2D NMR spectra and mass, UV, and IR spectra. Coprismycins A-B (1 and 2) and dipyridines (5 and 6) displayed comparable neuroprotective effects against MPP(+) (1-methyl-4-phenylpyrimidium)-induced neurotoxicity in neuroblastoma SH-SY5Y cells.

Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Line, Tumor; Cell Survival; Coleoptera; Dopamine; Drug Discovery; Molecular Structure; Neuroblastoma; Neuroprotective Agents; Neurotoxicity Syndromes; Oximes; Parkinsonian Disorders; Pyridines; Streptomyces