cassaine has been researched along with carvone* in 1 studies
1 other study(ies) available for cassaine and carvone
| Article | Year |
|---|---|
Anionic polycyclization entry to tricycles related to quassinoids and terpenoids: a stereocontrolled total synthesis of (+)-cassaine.
A full account of our anionic polycyclization approach to access highly functionalized tricycles related to quassinoids and terpenoids from several optically active bicyclic enone systems and Nazarov reagents is presented. (+)-Carvone is the only chiral source used to fix the entire stereochemistry of all of the tricycles, and the stereochemical outcome of this process was unambiguously determined by X-ray crystallographic analysis. The utility of this strategy was demonstrated by the stereocontrolled construction of advanced tricycles related to the highly potent anticancer natural product bruceantin, a member of quassinoid family, and the total synthesis of the cardioactive terpenoid (+)-cassaine, a nonsteroidal inhibitor of Na(+)-K(+)-ATPase. Topics: Abietanes; Alkaloids; Anions; Biological Products; Crystallography, X-Ray; Cyclization; Cyclohexane Monoterpenes; Humans; Monoterpenes; Quassins; Sodium-Potassium-Exchanging ATPase; Stereoisomerism; Terpenes | 2014 |