Compounds > azotochelin
Page last updated: 2024-12-08

azotochelin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

azotochelin: siderophore from Azotobacter vinelandii; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID193592
CHEMBL ID494132
CHEBI ID165185
SCHEMBL ID3441243
MeSH IDM0124036

Synonyms (22)

Synonym
azotochelin
C06446 ,
2-n,6-n-bis(2,3-dihydroxybenzoyl)-l-lysine
(2s)-2,6-bis[(2,3-dihydroxybenzoyl)amino]hexanoic acid
n2,n6-bis(2,3-dihydroxybenzoyl)-l-lysine
CHEBI:165185
23369-85-9
CHEMBL494132 ,
AC1L4WM2 ,
AC1Q5QRS ,
n,n'-bis(2,3-dihydroxybenzoyl)-l-lysine
l-lysine, n2,n6-bis(2,3-dihydroxybenzoyl)-
n,n'-bis(2,3-dihydroxybenzoyl)lysine
SCHEMBL3441243
surecn3441243
(s)-2,6-bis(2,3-dihydroxybenzamido)hexanoic acid
AKOS028113056
2-n,6-n-di-(2,3-dihydroxybenzoyl)-l-lysine
FT-0772121
95B ,
DTXSID50946040
n~2~,n~6~-bis[(2,3-dihydroxyphenyl)(hydroxy)methylidene]lysine

Research Excerpts

Overview

Azotochelin is a biscatecholate siderophore produced by the nitrogen-fixing soil bacterium Azotobacter vinelandii.

ExcerptReferenceRelevance
"Azotochelin is a biscatecholate siderophore produced by the nitrogen-fixing soil bacterium Azotobacter vinelandii. "( Complexation of oxoanions and cationic metals by the biscatecholate siderophore azotochelin.
Arnaud-Neu, F; Asfari, Z; Bellenger, JP; Kraepiel, AM; Myneni, SC; Stiefel, EI, 2007)		2.01

Bioavailability

ExcerptReferenceRelevance
"The acidification caused by the dissolution of anthropogenic carbon dioxide (CO2) in the ocean changes the chemistry and hence the bioavailability of iron (Fe), a limiting nutrient in large oceanic regions."( Effect of ocean acidification on iron availability to marine phytoplankton.
Hopkinson, BM; Morel, FM; Shi, D; Xu, Y, 2010)		0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
N-acylglycineAn N-acyl-amino acid in which amino acid specified is glycine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID418507Cytotoxicity against mouse 26-L5 cells at 7.5 uM after 24 hrs2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Synthesis and evaluation of myxochelin analogues as antimetastatic agents.
AID418504Antiinvasive activity against mouse 26-L5 cells assessed as inhibition of cell invasion by Matrigel assay2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Synthesis and evaluation of myxochelin analogues as antimetastatic agents.
AID418506Antiinvasive activity against mouse 26-L5 cells assessed as inhibition of cell invasion at 2.5 uM by Matrigel assay2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Synthesis and evaluation of myxochelin analogues as antimetastatic agents.
AID418505Cytotoxicity against mouse 26-L5 cells after 24 hrs2009Bioorganic & medicinal chemistry, Apr-01, Volume: 17, Issue:7
Synthesis and evaluation of myxochelin analogues as antimetastatic agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.11

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.11 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index5.01 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.11)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
spermidine
[no description available]		1.9910polyazaalkane;
triamine		autophagy inducer;
fundamental metabolite;
geroprotector
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		3.4270aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
edetic acid
Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.		2.0510ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid		anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector
2-methylpentane
Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.		2.2110alkane
cyanuric acid
cyanuric acid: RN given refers to parent cpd. isocyanuric acid : The keto tautomer of cyanuric acid.. cyanuric acid : The enol tautomer of isocyanuric acid.		1.99101,3,5-triazinanes;
1,3,5-triazines;
heteroaryl hydroxy compound		xenobiotic
vanadium
Vanadium: A metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.		2.0410elemental vanadium;
vanadium group element atom		micronutrient
cephalosporin c
cephalosporin C: RN given refers to parent cpd; structure in Merck, 9th ed, #1937. cephalosporin C : A cephalosporin antibiotic carrying a 3-acetoxymethyl substituent and a 6-oxo-N(6)-L-lysino group at position 7.		1.9910cephalosporinfungal metabolite
azotobactin
azotobactin: siderophore from Azotobacter vinelandii; structure given in first source		1.9610
myxochelin b
myxochelin B: isolated from Stigmatella aurantiaca; structure in first source. myxochelin B : A member of the class of benzamides obtained by formal condensation of the 1- and 6-amino groups of hexane-1,2,6-triamine with the carboxy groups from two molecules of 2,3-dihydroxybenzoic acid followed by reduction of the amide carbonyl at position 5 to a hydroxy group.		2.0510benzamides;
catechols		bacterial metabolite;
siderophore
myxochelin a
myxochelin A: structure given in first source; catechole siderophore isolated from Angiococcus disciformis		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Lung
[description not available]		02.0510
Metastase
[description not available]		02.0510
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0510
Neoplasm Metastasis
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.		02.0510