alpha-thujene profile

Alpha-thujene is a monoterpene hydrocarbon found in various plants, including Thuja occidentalis (Western Red Cedar) and Juniperus virginiana (Eastern Red Cedar). It is characterized by its distinctive aroma, often described as camphoraceous or woody. The compound has been studied for its potential biological activities, including antimicrobial, insecticidal, and anti-inflammatory properties. Its biosynthesis is thought to occur through the mevalonate pathway, involving enzymatic conversions of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). Researchers have investigated alpha-thujene's use in various applications, including:

* **Pharmaceutical applications:** Research suggests potential for antimicrobial and antifungal activity, though further studies are needed.
* **Agricultural applications:** Its insecticidal properties have led to investigations for use in pest control.
* **Cosmetic and fragrance industries:** Its distinctive aroma makes it a potential ingredient in fragrances and essential oils.

The importance of studying alpha-thujene lies in its potential for diverse applications and its role in plant biology. Further research could lead to new discoveries and applications in medicine, agriculture, and other industries.'

alpha-thujene: volatile oil constituent of Monodora myristica (Gaertn) Dunal; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

alpha-thujene : A thujene that has a bicyclo[3.1.0]hex-2-ene skeleton which is substituted at positions 2 and 5 by methyl and isopropyl groups, respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Monodora	genus	[no description available]	Annonaceae	The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.[MeSH]
Monodora myristica	species	[no description available]	Annonaceae	The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.[MeSH]

ID Source	ID
PubMed CID	17868
MeSH ID	M000596900

Synonym
bicyclo[3.1.0]hex-2-ene, 2-methyl-5-(1-methylethyl)-
3-thujene
2-methyl-5-(propan-2-yl)bicyclo[3.1.0]hex-2-ene
5-isopropyl-2-methylbicyclo[3.1.0]hex-2-ene
alpha-thujene
2867-05-2
2-methyl-5-(1-methylethyl)-bicyclo[3.1.0]hex-2-ene
(1r,5s)-2-methyl-5-(propan-2-yl)bicyclo[3.1.0]hex-2-ene
2-methyl-5-propan-2-ylbicyclo[3.1.0]hex-2-ene
4-methyl-1-propan-2-ylbicyclo[3.1.0]hex-3-ene
FT-0622205
2-methyl-5-(1-methylethyl)-bicyclo(3.1.0)hex-2-ene
5-isopropyl-2-methylbicyclo[3.1.0]hex-2-ene #
thujene, .alpha.-
(1r,5s)-thuj-2-ene
(-)-3-thujene
thujene (alpha-)
DTXSID20863038
Q27121796
thujone,(a + b)(sg)
EN300-7441739
thujone, (a + b)(sg)

Class	Description
thujene	A monoterpene based on a thujane skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (100.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
inositol Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.. inositol : Any cyclohexane-1,2,3,4,5,6-hexol.. 1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.. muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.	2.15	1	cyclitol; hexol
linalool linalool: RN given refers to parent cpd without isomeric designation; structure. linalool : A monoterpenoid that is octa-1,6-diene substituted by methyl groups at positions 3 and 7 and a hydroxy group at position 3. It has been isolated from plants like Ocimum canum.	2.84	3	monoterpenoid; tertiary alcohol	antimicrobial agent; fragrance; plant metabolite; volatile oil component
alpha-pinene [no description available]	2.55	2	pinene	plant metabolite
thymol Thymol: A phenol obtained from thyme oil or other volatile oils used as a stabilizer in pharmaceutical preparations, and as an antiseptic (antibacterial or antifungal) agent.. thymol : A phenol that is a natural monoterpene derivative of cymene.	2.15	1	monoterpenoid; phenols	volatile oil component
alpha phellandrene alpha phellandrene: can be irritating to, & absorbed by the skin; ingestion can cause vomiting, diarrhea; RN given refers to cpd without isomeric designation; structure. alpha-phellandrene : One of a pair of phellandrene cyclic monoterpene double-bond isomers in which both double bonds are endocyclic (cf. alpha-phellandrene, where one of them is exocyclic).	2.07	1	cyclohexadiene; phellandrene	antimicrobial agent; plant metabolite; volatile oil component
gamma-terpinene gamma-terpinene: RN given refers to gamma-terpinene; structure. gamma-terpinene : One of three isomeric monoterpenes differing in the positions of their two double bonds (alpha- and beta-terpinene being the others). In gamma-terpinene the double bonds are at the 1- and 4-positions of the p-menthane skeleton.	2.57	2	cyclohexadiene; monoterpene	antioxidant; human xenobiotic metabolite; plant metabolite; volatile oil component
4-cymene 4-cymene: structure. p-cymene : A monoterpene that is toluene substituted by an isopropyl group at position 4.	2.17	1	monoterpene; toluenes	human urinary metabolite; plant metabolite; volatile oil component
carvacrol carvacrol : A phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).	2.15	1	botanical anti-fungal agent; p-menthane monoterpenoid; phenols	agrochemical; antimicrobial agent; flavouring agent; TRPA1 channel agonist; volatile oil component
beta-pinene beta-pinene: alpha-pinene is also available. beta-pinene : An isomer of pinene with an exocyclic double bond. It is a component of essential oils from many plants.	2.55	2	pinene	plant metabolite
alpha-terpineol terpineol : A family of monoterpenols that have a p-menthane skeleton containing one double bond and bearing a single hydroxy substituent.	2.15	1	terpineol	plant metabolite
myrcene myrcene: structure in first source. beta-myrcene : A monoterpene that is octa-1,6-diene bearing methylene and methyl substituents at positions 3 and 7 respectively.	2.57	2	monoterpene	anabolic agent; anti-inflammatory agent; flavouring agent; fragrance; plant metabolite; volatile oil component
alkenes [no description available]	2.57	2
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.13	1	D-glucopyranose	epitope; mouse metabolite
sesquiterpenes [no description available]	2.15	1
galactaric acid galactaric acid: STRUCTURE; RN given refers to parent cpd. galactaric acid : A hexaric acid resulting from formal oxidative ring cleavage of galactose.	2.15	1	hexaric acid	human metabolite
caryophyllene caryophyllene: RN given refers to cpd without isomeric designation; structure given in first source	2.15	1
beta-elemene beta-elemene: increases tumor cell immunogenicity by inducing, at least in part, elevated expression of heat shock protein 70 on tumor cell surface. beta-elemene : A sesquiterpene that consists of cyclohexane bearing methyl and vinyl substituents at position 1 as well as two isopropenyl substituents at positions 2 and 4.. (-)-beta-elemene : The (-)-enantiomer of beta-elemene that has (1S,2S,4R)-configuration.	2.15	1	beta-elemene	antineoplastic agent
phillyrin [no description available]	2.13	1

alpha-thujene

Description

Cross-References

Synonyms (22)

Drug Classes (1)

Research

Studies (5)

Market Indicators

Research Demand Index: 40.90

Study Types