Page last updated: 2024-10-24

protein K27-linked deubiquitination

Definition

Target type: biologicalprocess

A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein. [PMID:23827681]

Proteins (1)

ProteinDefinitionTaxonomy
Ubiquitin carboxyl-terminal hydrolase 15A ubiquitin carboxyl-terminal hydrolase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4E8]Homo sapiens (human)

Compounds (2)

CompoundDefinitionClassesRoles
celastrolmonocarboxylic acid;
pentacyclic triterpenoid
anti-inflammatory drug;
antineoplastic agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
Hsp90 inhibitor;
metabolite
acetyl isogambogic acidacetyl isogambogic acid: structure in first source