Target type: molecularfunction
A molecular adaptor that recognizes and binds a histone protein containing a ubiquitination modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way. [GOC:dph, PMID:24526689]
Ubiquitin-modified histone reader activity is a molecular function that enables proteins to recognize and bind to ubiquitin modifications on histone proteins. Histones are the proteins that package and order DNA into nucleosomes, the fundamental units of chromatin. Ubiquitylation of histones is a dynamic post-translational modification that can alter chromatin structure and function, influencing a wide range of cellular processes including transcription, DNA repair, and replication. Ubiquitin-modified histone readers bind to these modified histones through specific protein domains, such as ubiquitin-binding domains (UBDs). These interactions allow the readers to recognize and interpret the ubiquitin code on histones, triggering downstream signaling events. For example, some ubiquitin-modified histone readers can recruit chromatin remodeling complexes or histone modifiers, leading to changes in gene expression. Others may act as scaffolding proteins, bringing together different components of the cellular machinery to regulate specific cellular processes. Overall, ubiquitin-modified histone reader activity plays a crucial role in regulating chromatin dynamics and cellular function by recognizing and interpreting the ubiquitin code on histones.'
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Protein | Definition | Taxonomy |
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Ubiquitin carboxyl-terminal hydrolase 15 | A ubiquitin carboxyl-terminal hydrolase 15 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y4E8] | Homo sapiens (human) |
TP53-binding protein 1 | A TP53-binding protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q12888] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
celastrol | monocarboxylic acid; pentacyclic triterpenoid | anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite | |
acetyl isogambogic acid | acetyl isogambogic acid: structure in first source | ||
(5-bromo-3-pyridinyl)-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone | aromatic carboxylic acid; pyridinemonocarboxylic acid | ||
entecavir | benzamides; N-acylpiperidine |