Ino80 complex
Definition
Target type: cellularcomponent
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity. [GOC:jh, GOC:rb, PMID:19355820]
The Ino80 complex is a large, multi-subunit protein complex that plays a critical role in chromatin remodeling, a process essential for DNA replication, transcription, and repair. The complex is found in the nucleus, specifically associated with chromatin, which is the complex of DNA and proteins that makes up chromosomes.
The Ino80 complex comprises multiple subunits, each contributing to its overall function:
- **Ino80:** This subunit, named after the yeast gene where it was first discovered, is the core catalytic component of the complex. It harbors ATPase activity, which is crucial for the complex's ability to remodel chromatin.
- **Ies1:** This subunit is a histone H4-specific acetyltransferase. It plays a role in histone acetylation, a crucial modification that influences chromatin accessibility and gene expression.
- **Ies2:** A histone H3-specific acetyltransferase. Its role is to acetylate histone H3, another modification impacting chromatin structure.
- **Ies4:** This subunit is a scaffolding component of the complex, playing a role in maintaining the integrity of the Ino80 complex structure.
- **Ies6:** This subunit is a histone H2B-specific ubiquitin ligase. It is involved in the ubiquitination of histone H2B, a modification linked to chromatin dynamics and gene expression.
- **Ies7:** This subunit is a chromatin-binding component of the complex. It facilitates the recruitment of the Ino80 complex to specific regions of the genome.
- **Ies9:** This subunit interacts with the histone H3 tail and has been implicated in DNA repair processes.
- **Ies10:** This subunit is a histone H3-specific lysine demethylase. It removes methyl groups from histone H3, potentially influencing chromatin accessibility and gene expression.
- **Ies20:** A subunit with a role in the localization of the Ino80 complex to specific regions of the genome, likely through its interaction with chromatin.
The Ino80 complex, through its diverse subunit composition, acts as a multi-functional chromatin remodeler. It utilizes its ATPase activity and histone modifying capabilities to alter chromatin structure, contributing to a wide range of cellular processes such as DNA replication, transcription, and DNA repair.'
"
Proteins (3)
| Protein | Definition | Taxonomy |
|---|---|---|
| Ubiquitin carboxyl-terminal hydrolase isozyme L5 | A ubiquitin carboxyl-terminal hydrolase isozyme L5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y5K5] | Homo sapiens (human) |
| RuvB-like 1 | A RuvB-like 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y265] | Homo sapiens (human) |
| RuvB-like 2 | A RuvB-like 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y230] | Homo sapiens (human) |
Compounds (6)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| tiaprofenic acid | tiaprofenic acid : An aromatic ketone that is thiophene substituted at C-2 by benzoyl and at C-4 by a 1-carboxyethyl group. tiaprofenic acid: RN given refers to parent cpd; structure | aromatic ketone; monocarboxylic acid; thiophenes | drug allergen; non-steroidal anti-inflammatory drug |
| celastrol | monocarboxylic acid; pentacyclic triterpenoid | anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite | |
| sorafenib | (trifluoromethyl)benzenes; aromatic ether; monochlorobenzenes; phenylureas; pyridinecarboxamide | angiogenesis inhibitor; anticoronaviral agent; antineoplastic agent; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; ferroptosis inducer; tyrosine kinase inhibitor | |
| rottlerin | rottlerin : A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis. rottlerin: an angiogenesis inhibitor; an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III; RN refers to (E)-isomer; do not confuse this chalcone with an anthraquinone that is also called rottlerin (RN 481-72-1); | aromatic ketone; benzenetriol; chromenol; enone; methyl ketone | anti-allergic agent; antihypertensive agent; antineoplastic agent; apoptosis inducer; K-ATP channel agonist; metabolite |
| acetyl isogambogic acid | acetyl isogambogic acid: structure in first source | ||
| akt-i-1,2 compound | Akt-I-1,2 compound: an aminopeptidase P inhibitor; structure in first source |