Page last updated: 2024-12-08

abt 491

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ABT 491: a highly potent platelet-activating factor receptor antagonist; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	154086
SCHEMBL ID	7943577
MeSH ID	M0278815

Synonyms (25)

Synonym
abt-491 hydrochloride, >=98% (hplc)
abt-491
1h-indole-1-carboxamide, 4-ethynyl-3-(3-fluoro-4-((2-methyl-1h-imidazo(4,5-c)pyridin-1-yl)methyl)benzoyl)-n,n-dimethyl-, monohydrochloride
4-ethynyl-3-(3-fluoro-4-((2-methyl-1h-imidazo(4,5-c)pyridin-1-yl)methyl)benzoyl)-n,n-dimethyl-1h-indole-1-carboxamide monohydrochloride
abt 491 hydrochloride
unii-n7ig7z867j
4-ethynyl-n,n-dimethyl-3-(3-fluoro-4-((2-methyl-1h-imidazo-(4,5-c)pyridin-1-yl)methyl)benzoyl)-1h-indole-1-carboxamide hydrochloride
n7ig7z867j ,
abt 491
4-ethynyl-n,n-dimethyl-3-[3-fluoro-4-[(2-methyl-1h-imidazo-[4,5-c]pyridin-1-yl)methyl]benzoyl]-1h-indole-1-carboxamide hydrochloride
189689-94-9
abt-491 hydrochloride
a-137491
AKOS015889278
methyl-1h-imidazo(4,5-c)pyridin-1-yl)methyl)benzoyl)-n,n-dimethyl-, hydrochloride
(4-ethynyl-n,n-dimethyl-3-(3-fluoro-4-((2-methyl-1h-imidazo-(4,5-c)pyridin-1-yl)methyl)benzoyl)-1h-indole-1-carboxamide hydrochloride
SCHEMBL7943577
DTXSID90172381
J-012241
4-ethynyl-3-(3-fluoro-4-((2-methyl-1h-imidazo[4,5-c]pyridin-1-yl)methyl)benzoyl)-n,n-dimethyl-1h-indole-1-carboxamide hydrochloride
paf receptor antagonist, abt-491 - cas 189689-94-9
a 137491
4-ethynyl-3-[3-fluoro-4-[(2-methyl-3h-imidazo[4,5-c]pyridin-1-ium-1-yl)methyl]benzoyl]-n,n-dimethylindole-1-carboxamide;chloride
4-ethynyl-3-[3-fluoro-4-[(2-methylimidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-n,n-dimethylindole-1-carboxamide;hydrochloride
1h-indole-1-carboxamide, 4-ethynyl-3-[3-fluoro-4-[(2-methyl-1h-imidazo[4,5-c]pyridin-1-yl)methyl]benzoyl]-n,n-dimethyl-, hydrochloride (1:1)

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (33.33)	18.2507
2000's	1 (11.11)	29.6817
2010's	3 (33.33)	24.3611
2020's	2 (22.22)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	21.20 (24.57)
Research Supply Index	2.30 (2.92)
Research Growth Index	5.15 (4.65)
Search Engine Demand Index	20.59 (26.88)
Search Engine Supply Index	3.50 (0.95)

This Compound (21.20)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
phosphorylcholine Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.. phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.	2.21	1	phosphocholines	allergen; epitope; hapten; human metabolite; mouse metabolite
cyclofenil Cyclofenil: A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.	2.08	1	organic molecular entity
thiazoles [no description available]	2.17	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
dihydrotestosterone Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.	2.08	1	17beta-hydroxy steroid; 17beta-hydroxyandrostan-3-one; 3-oxo-5alpha-steroid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.25	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
mifepristone Mifepristone: A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.	2.08	1	3-oxo-Delta(4) steroid; acetylenic compound; tertiary amino compound	abortifacient; contraceptive drug; hormone antagonist; synthetic oral contraceptive
1-hexadecyl-2-acetyl-glycero-3-phosphocholine Platelet Activating Factor: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.. 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine : A 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine betaine which has hexadecyl as the alkyl group. PAF is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation, inflammation, and anaphylaxis.	3.28	6	2-acetyl-1-alkyl-sn-glycero-3-phosphocholine	antihypertensive agent; beta-adrenergic antagonist; bronchoconstrictor agent; hematologic agent; vasodilator agent
foropafant Foropafant: structure given in first source; PAF antagonist	2.17	1

Condition	Relationship Strength	Studies
Anaphylactic Reaction [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.49	2
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	2.25	1
Disease Exacerbation [description not available]	2.54	2
Androgen-Independent Prostatic Cancer [description not available]	2.25	1
Prostatic Neoplasms, Castration-Resistant Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.	2.25	1
Cancer of Prostate [description not available]	2.08	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.08	1
Anoxia-Ischemia, Brain [description not available]	2.03	1
Hypoxia-Ischemia, Brain A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.	2.03	1
Innate Inflammatory Response [description not available]	1.99	1
Circulatory Collapse [description not available]	1.99	1
Acute Disease Disease having a short and relatively severe course.	1.99	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	1.99	1
Shock A pathological condition manifested by failure to perfuse or oxygenate vital organs.	1.99	1
Endotoxemia A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.	1.99	1
Rhinitis, Allergic, Nonseasonal [description not available]	1.99	1
Rhinitis, Allergic, Perennial Inflammation of the mucous membrane of the nose similar to that found in hay fever except that symptoms persist throughout the year. The causes are usually air-borne allergens, particularly dusts, feathers, molds, animal fur, etc.	1.99	1
Allergic Reaction [description not available]	1.99	1
Nasal Catarrh [description not available]	1.99	1
Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	1.99	1
Rhinitis Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.	1.99	1

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