Compounds > abt 491
Page last updated: 2024-09-04

abt 491 and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine

abt 491 has been researched along with 1-hexadecyl-2-acetyl-glycero-3-phosphocholine in 6 studies

Compound Research Comparison

Studies
(abt 491)		Trials
(abt 491)		Recent Studies (post-2010)
(abt 491)		Studies
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)		Trials
(1-hexadecyl-2-acetyl-glycero-3-phosphocholine)		Recent Studies (post-2010) (1-hexadecyl-2-acetyl-glycero-3-phosphocholine)
9059,156187552

Protein Interaction Comparison

ProteinTaxonomyabt 491 (IC50)1-hexadecyl-2-acetyl-glycero-3-phosphocholine (IC50)
Platelet-activating factor receptorHomo sapiens (human)0.0003

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (50.00)18.2507
2000's1 (16.67)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Albert, DH; Carter, GW; Curtin, M; Davidsen, SK; Heyman, HR; Luo, G; Magoc, TJ; Morgan, DW; Sheppard, GS; Summers, JB; Tapang, P; Xu, L1
Albert, DH; Carter, GW; Curtin, ML; Davidsen, SK; Morgan, DW; Sheppard, GS; Summers, JB; Tapang, P1
Albert, DH; Carter, GW; Curtin, ML; Davidsen, SK; Malo, PE; Morgan, DW; Shaughnessy, TK; Sheppard, GS; Summers, JB; Tapang, P; Wegner, CD; Xu, L1
Atici, A; Bozlu, G; Nayci, A; Okuyaz, C; Polat, A; Taskinlar, H; Turhan, AH1
Gao, L; He, M; Ni, X; Sun, Y; Tang, G; Wang, L; Xu, B; Yu, Y1
Han, C; Li, L; Li, M; Liu, Y; Mao, Y; Song, S; Wang, Z; Xu, B; Yu, G; Zhou, L1

Other Studies

6 other study(ies) available for abt 491 and 1-hexadecyl-2-acetyl-glycero-3-phosphocholine

ArticleYear
Pharmacology of ABT-491, a highly potent platelet-activating factor receptor antagonist.
    European journal of pharmacology, 1997, Apr-23, Volume: 325, Issue:1

    Topics: Acute Disease; Animals; Blood Platelets; Dose-Response Relationship, Drug; Endotoxemia; Guinea Pigs; Humans; Imidazoles; Indoles; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Rabbits; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Shock

1997
ABT-491, a highly potent and selective PAF antagonist, inhibits nasal vascular permeability associated with experimental allergic rhinitis in brown Norway rats.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46 Suppl 2

    Topics: Animals; Capillary Permeability; Imidazoles; Indoles; Kinetics; Nasal Mucosa; Platelet Activating Factor; Rats; Rats, Inbred BN; Rhinitis, Allergic, Perennial

1997
The role of platelet-activating factor (PAF) and the efficacy of ABT-491, a highly potent and selective PAF antagonist, in experimental allergic rhinitis.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:1

    Topics: Airway Resistance; Animals; Capillary Permeability; Guinea Pigs; Hypersensitivity; Imidazoles; Indoles; Male; Platelet Activating Factor; Rats; Rats, Inbred BN; Rhinitis

1998
Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury.
    Brain research, 2007, Apr-27, Volume: 1143

    Topics: Analysis of Variance; Animals; Animals, Newborn; Apoptosis; Caspase 3; Cell Count; Disease Models, Animal; Drug Administration Schedule; Hypoxia-Ischemia, Brain; Imidazoles; In Situ Nick-End Labeling; Indoles; Platelet Activating Factor; Rats

2007
Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers.
    British journal of cancer, 2013, Sep-03, Volume: 109, Issue:5

    Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Androgen Receptor Antagonists; Androgens; beta Catenin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclofenil; Dihydrotestosterone; Disease Progression; Estradiol; Hormone Antagonists; Humans; Imidazoles; Indoles; Male; Mifepristone; Platelet Activating Factor; Prostatic Neoplasms; Protein Kinase Inhibitors; RNA Interference; RNA, Small Interfering; Wnt Proteins

2013
LPCAT1 enhances castration resistant prostate cancer progression via increased mRNA synthesis and PAF production.
    PloS one, 2020, Volume: 15, Issue:11

    Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Indoles; Male; Mice; Paclitaxel; PC-3 Cells; Platelet Activating Factor; Prostatic Neoplasms, Castration-Resistant; Up-Regulation

2020