Compounds > a 74273

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a 74273

Description

A 74273: structure given in first source [MeSH]

Cross-References

ID Source	ID
PubMed CID	20832757
MeSH ID	M0209805

Synonyms (5)

Synonym
a 74273
130316-95-9
a-74273
6-cyclohexyl-4-hydroxy-5-[2-[1-[4-(methoxymethoxy)piperidin-1-yl]-1-oxo-3-phenylpropan-2-yl]oxyhexanoylamino]-n-(3-morpholin-4-ylpropyl)-2-propan-2-ylhexanamide
AKOS040747668

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (25.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (75.00%)	84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
oxyquinoline	1	monohydroxyquinoline	antibacterial agent; antifungal agrochemical; antiseptic drug; iron chelator	1992	1992	32.0	medium	0	0	1	0	0	0
phenylmethylsulfonyl fluoride	1	acyl fluoride	serine proteinase inhibitor	1992	1992	32.0	medium	0	0	1	0	0	0
histidine	1	amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite	1992	1992	32.0	medium	0	0	1	0	0	0
oxazoles	1	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		1992	1992	32.0	medium	0	0	1	0	0	0
thiazoles	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		1994	1994	30.0	medium	0	0	1	0	0	0
enalkiren	2	peptide		1992	1998	29.0	high	0	0	2	0	0	0
oxazolidin-2-one	1	carbamate ester; oxazolidinone	metabolite	1992	1992	32.0	medium	0	0	1	0	0	0
zankiren hydrochloride	1			1994	1994	30.0	medium	0	0	1	0	0	0
ro 42-5892	1	cyclopropanes; diol; L-histidine derivative; secondary carboxamide; sulfone	antihypertensive agent; EC 3.4.23.15 (renin) inhibitor; peptidomimetic; vasodilator agent	1994	1994	30.0	medium	0	0	1	0	0	0

Condition	Indicated	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
Blood Pressure, High	0	1	1994	1994	30.0	medium	0	0	1	0	0	0
Blood Pressure, Low	0	1	1993	1993	31.0	medium	0	0	1	0	0	0
Cardiac Failure	0	1	1994	1994	30.0	medium	0	0	1	0	0	0
Heart Failure	0	1	1994	1994	30.0	medium	0	0	1	0	0	0
Hypertension	0	1	1994	1994	30.0	medium	0	0	1	0	0	0
Hypotension	0	1	1993	1993	31.0	medium	0	0	1	0	0	0

Bioavailability (4)

Article	Year
Renin inhibition: a new approach to cardiovascular therapy. Journal of clinical pharmacology, , Volume: 34, Issue:9	1994
Nonpeptide renin inhibitors with good intraduodenal bioavailability and efficacy in dog. Journal of medicinal chemistry, , Sep-16, Volume: 37, Issue:19	1994
Effects of high doses of A-74273, a novel nonpeptidic and orally bioavailable renin inhibitor. Journal of cardiovascular pharmacology, , Volume: 21, Issue:1	1993
Discovery of a well-absorbed, efficacious renin inhibitor, A-74273. Hypertension (Dallas, Tex. : 1979), , Volume: 20, Issue:6	1992

Dosage (2)

Article	Year
The orally active renin inhibitor A-74273. In vivo and in vitro morpholine ring metabolism in rats, dogs, and humans. Drug metabolism and disposition: the biological fate of chemicals, , Volume: 22, Issue:6
Discovery of a well-absorbed, efficacious renin inhibitor, A-74273. Hypertension (Dallas, Tex. : 1979), , Volume: 20, Issue:6	1992