Compounds > 4,4,10-trimethyl-trans-decal-3-ol
Page last updated: 2024-11-12

4,4,10-trimethyl-trans-decal-3-ol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

4,4,10-trimethyl-trans-decal-3-ol: specific 2,3-oxidosqualene-lanosterol cyclase inhibitor; RN given refers to (2alpha,4aalpha,8abeta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11127203
CHEMBL ID308982
SCHEMBL ID7107640
MeSH IDM0077905

Synonyms (25)

Synonym
CHEMBL308982 ,
TMD ,
4,4,10-trimethyl-trans-decal-3-ol
1,1,4a-trimethyl-decahydro-naphthalen-2-ol
(2s,4as,8ar)-1,1,4a-trimethyl-decahydro-naphthalen-2-ol
bdbm50003030
60761-10-6
7vm2yk5nyy ,
unii-7vm2yk5nyy
(2alpha,4aalpha,8abeta)-decahydro-1,1,4a-trimethyl-2-naphthalenol
SCHEMBL7107640
4,4,10beta-trimethyl-trans-decal-3beta-ol, (-)-
unii-6ook4clu1y
tmd l-form [mi]
58193-61-6
2-naphthalenol, decahydro-1,1,4a-trimethyl-, (2s,4as,8ar)-
tmd [mi]
2-naphthalenol, decahydro-1,1,4a-trimethyl-, (2r,4ar,8as)-rel-
4,4,10.beta.-trimethyl-trans-decal-3.beta.-ol, (+/-)-
4,4,10.beta.-trimethyl-trans-decal-3.beta.-ol
1,1,10-trimethyl-trans-2-decalol, (-)-
106949-60-4
4,4,10.beta.-trimethyl-trans-decal-3.beta.-ol, (-)-
1,1,10-trimethyl-trans-2-decalol
6OOK4CLU1Y ,
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Lanosterol synthase Rattus norvegicus (Norway rat)IC50 (µMol)9.00000.05304.52659.0000AID151662
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID151664Inhibitory activity against Oxidosqualene-lanosterol cyclase from Rat liver microsomes1996Journal of medicinal chemistry, Jun-07, Volume: 39, Issue:12
Structural and stereoelectronic requirements for the inhibition of mammalian 2,3-oxidosqualene cyclase by substituted isoquinoline derivatives.
AID86568Compound was tested for inhibition of cholesterol biosynthesis in HepG2 cells from [14C]- acetate1992Journal of medicinal chemistry, Sep-18, Volume: 35, Issue:19
N-(1-oxododecyl)-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase.
AID151662Inhibitory activity against Oxidosqualene-lanosterol cyclase enzyme obtained from rat liver1992Journal of medicinal chemistry, Sep-18, Volume: 35, Issue:19
N-(1-oxododecyl)-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (33.33)18.7374
1990's4 (66.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ketoconazole
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.		1.9710dichlorobenzene;
dioxolane;
ether;
imidazoles;
N-acylpiperazine;
N-arylpiperazine
2-naphthol
2-naphthol: RN given refers to parent cpd. 2-naphthol : A naphthol carrying a hydroxy group at position 2.. naphthols : Any hydroxynaphthalene derivative that has a single hydroxy substituent.		2.8940naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
amo-1618
AMO-1618: RN given refers to chloride with piperidinyl group in position 1; structure		1.9710
lovastatin
Lovastatin: A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver.. lovastatin : A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).		2.3920delta-lactone;
fatty acid ester;
hexahydronaphthalenes;
polyketide;
statin (naturally occurring)		anticholesteremic drug;
antineoplastic agent;
Aspergillus metabolite;
prodrug
25-hydroxycholesterol
[no description available]		2.382025-hydroxy steroid;
oxysterol		human metabolite
lanosterol
[no description available]		1.971014alpha-methyl steroid;
3beta-sterol;
tetracyclic triterpenoid		bacterial metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
mevalonic acid
Mevalonic Acid: A dihydroxy monocarboxylic acid and precursor in the biosynthetic pathway known as the mevalonate pathway, which produces terpenes and steroids that are vital for diverse cellular functions.. mevalonic acid : A racemate composed of equimolar amounts of (R)- and (S)-mevalonic acid.. (R)-mevalonic acid : The (R)-enantiomer of mevalonic acid.		2.67303,5-dihydroxy-3-methylpentanoic acid
3-hydroxy-3-methylglutaryl-coenzyme a
3-hydroxy-3-methylglutaryl-coenzyme A: RN given refers to cpd without isomeric designation. 3-hydroxy-3-methylglutaryl-CoA : An alpha,omega dicarboxyacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with one of the carboxy groups of 3-hydroxy-3-methylglutaric acid.. (3S)-3-hydroxy-3-methylglutaryl-CoA : A 3-hydroxy-3-methylglutaryl-CoA where the 3-hydroxy-3-methylglutaryl component has (S)-configuration.		1.97103-hydroxy-3-methylglutaryl-CoA;
3-hydroxy fatty acyl-CoA		human metabolite;
mouse metabolite
squalene
Addavax: an oil-water nanoemulsion and adjuvant containing squalene, Tween 80, and sorbitane trioleate		2.3720triterpenehuman metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
squalestatin 1
squalestatin 1: structure given in first source; inhibits both mammalian and fungal squalene synthetase; from fungus Phoma sp (Coelomycetes). zaragozic acid A : A polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase.		1.9910acetate ester;
cyclic ketal;
oxabicycloalkane;
polyketide;
tertiary alcohol;
tricarboxylic acid		EC 2.5.1.21 (squalene synthase) inhibitor;
fungal metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Experimental Hepatoma
[description not available]		01.9710