Page last updated: 2024-12-06

3-methyl-n,n-diethyl-p-phenylenediamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-methyl-N,N-diethyl-p-phenylenediamine: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID67364
CHEMBL ID2094307
SCHEMBL ID34104
MeSH IDM0061744

Synonyms (50)

Synonym
EU-0033282
1,4-benzenediamine, n4,n4-diethyl-2-methyl-
n-4,n-4-diethyl-2-methyl-1,4-benzenediamine
BB 0255063
n-4,n-4-diethyl-2-methyl-1,4-phenylenediamine
n1,n1-diethyl-3-methyl-para-phenylenediamine
CBDIVE_002948
HMS1648D07
4-n,4-n-diethyl-2-methylbenzene-1,4-diamine
AKOS001583185
NCGC00240840-01
STK793049
n~4~,n~4~-diethyl-2-methylbenzene-1,4-diamine
4-diethylamino-o-toluidine
a640zq81dv ,
unii-a640zq81dv
3-methyl-n,n-diethyl-p-phenylenediamine
148-71-0
einecs 205-722-1
bdbm50429681
dndi1416906
CHEMBL2094307 ,
FT-0681391
cd-2
SCHEMBL34104
n4,n4-diethyl-2-methyl-1,4benzenediamine
4-amino-3-methyl-(n,n-diethyl)aniline
2-methyl-4-diethylaminoaniline
2-amino-5-diethylaminotoluene
diethyl-2-methyl-p-phenylenediamine
DTXSID7043879
2-amino-5-diethylamino-toluene, monohydrochloride (salt/mix)
4-amino-3-methyl-n,n-diethylaniline
toluene-2,5-diamine, n5,n5-diethyl-, hydrochloride (salt/mix)
toluene-2,5-diamine, n5,n5-diethyl-
n4,n4-diethyl-2-methyl-p-phenylenediamine
n1,n1-diethyl-3-methylbenzene-1,4-diamine
W-109516
4-amino-n,n-diethyl-3-methylaniline
3-methyl-4-amino-n,n-diethylaniline
4-(diethylamino)-2-methylbenzene-1-amine
n,n-diethyl-3-methyl-p-phenylenediamine
1-(diethylamino)-3-methylbenzene-4-amine
2-amino-5-(diethylamino)toluene
4-(diethylamino)-o-toluidine
4-(diethylamino)-2-methylaniline
4-(n,n-diethylamino)-2-methylaniline
n4,n4-diethyl-2-methyl-1,4-benzenediamine
color developer cd-2
Q27273683
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Protein S100-BHomo sapiens (human)IC50 (µMol)8.40008.40008.40008.4000AID734556
Protein S100-BHomo sapiens (human)Ki5.00005.00005.00005.0000AID734556
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (11)

Processvia Protein(s)Taxonomy
cell adhesionProtein S100-BHomo sapiens (human)
axonogenesisProtein S100-BHomo sapiens (human)
central nervous system developmentProtein S100-BHomo sapiens (human)
learning or memoryProtein S100-BHomo sapiens (human)
memoryProtein S100-BHomo sapiens (human)
positive regulation of canonical NF-kappaB signal transductionProtein S100-BHomo sapiens (human)
positive regulation of neuron differentiationProtein S100-BHomo sapiens (human)
regulation of neuronal synaptic plasticityProtein S100-BHomo sapiens (human)
sympathetic neuron projection extensionProtein S100-BHomo sapiens (human)
adaptive thermogenesisProtein S100-BHomo sapiens (human)
positive regulation of cell population proliferationProtein S100-BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (9)

Processvia Protein(s)Taxonomy
calcium ion bindingProtein S100-BHomo sapiens (human)
protein bindingProtein S100-BHomo sapiens (human)
zinc ion bindingProtein S100-BHomo sapiens (human)
identical protein bindingProtein S100-BHomo sapiens (human)
protein homodimerization activityProtein S100-BHomo sapiens (human)
S100 protein bindingProtein S100-BHomo sapiens (human)
tau protein bindingProtein S100-BHomo sapiens (human)
calcium-dependent protein bindingProtein S100-BHomo sapiens (human)
RAGE receptor bindingProtein S100-BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (10)

Processvia Protein(s)Taxonomy
extracellular regionProtein S100-BHomo sapiens (human)
ruffleProtein S100-BHomo sapiens (human)
extracellular regionProtein S100-BHomo sapiens (human)
nucleusProtein S100-BHomo sapiens (human)
nucleoplasmProtein S100-BHomo sapiens (human)
cytoplasmProtein S100-BHomo sapiens (human)
cytosolProtein S100-BHomo sapiens (human)
neuronal cell bodyProtein S100-BHomo sapiens (human)
intracellular membrane-bounded organelleProtein S100-BHomo sapiens (human)
perinuclear region of cytoplasmProtein S100-BHomo sapiens (human)
cytoplasmProtein S100-BHomo sapiens (human)
nucleusProtein S100-BHomo sapiens (human)
extracellular spaceProtein S100-BHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID734556Inhibition of human S100B/human TAMRA-p53(367-388) interaction by fluorescence polarization assay2013Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5
Identification of small-molecule inhibitors of the human S100B-p53 interaction and evaluation of their activity in human melanoma cells.
AID734553Cytotoxicity against human WM115 cells assessed as growth inhibition measured after 72 hrs by crystal violet assay2013Bioorganic & medicinal chemistry, Mar-01, Volume: 21, Issue:5
Identification of small-molecule inhibitors of the human S100B-p53 interaction and evaluation of their activity in human melanoma cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (31.58)18.7374
1990's4 (21.05)18.2507
2000's0 (0.00)29.6817
2010's4 (21.05)24.3611
2020's5 (26.32)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.04 (24.57)
Research Supply Index3.04 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies5 (25.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (75.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]