3,4-epoxybutane-1,2-diol: a butadiene metabolite [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 108199 |
| SCHEMBL ID | 147455 |
| MeSH ID | M0214046 |
| Synonym |
|---|
| 1-oxiranyl-1,2-ethanediol |
| 3,4-epoxy-1,2-butanediol |
| ccris 7903 |
| brn 1633586 |
| 1,2-ethanediol, 1-oxiranyl- |
| 3,4-epoxybutane-1,2-diol |
| 1,2-epoxybutane-3,4-diol |
| 1,2-butanediol, 3,4-epoxy- |
| (1,2-dihydroxyethyl)oxirane |
| 17177-50-3 |
| 1-(oxiran-2-yl)ethane-1,2-diol |
| 1,2-ethanediol, 1-oxiranyl-, (r*,s*)- |
| 146611-76-9 |
| 5-17-05-00013 (beilstein handbook reference) |
| SCHEMBL147455 |
| FT-0721596 |
| DTXSID401030933 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " EBD and its analog with a hydroxy substituent at C1 were found to be highly toxic to FANCD2-deficient chicken and human cells." | ( An unexpected butadiene diolepoxide-mediated genotoxicity implies alternative mechanism for 1,3-butadiene carcinogenicity. Carro, S; Gold, A; Nakamura, J; Zhang, Z, 2021) | 0.62 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dose-response for BMO followed a second order curve at this time interval, with maximum MN induction at the dose of 186 mumol/kg and lower induction of higher doses." | ( Germ cell mutagenicity of three metabolites of 1,3-butadiene in the rat: induction of spermatid micronuclei by butadiene mono-, di-, and diolepoxides in vivo. Lähdetie, J; Peltonen, K; Sjöblom, T, 1997) | 0.3 |
| " The dose-response for mutations induced at the cII locus was essentially equal after DEB exposure of BBM1 and BBR1 fibroblasts." | ( Micronuclei and gene mutations in transgenic big Blue((R)) mouse and rat fibroblasts after exposure to the epoxide metabolites of 1, 3-butadiene. Erexson, GL; Tindall, KR, 2000) | 0.31 |
| " We previously demonstrated similarities in the shapes of the dose-response curves for EB-diol derived DNA adducts, hemoglobin adducts, and Hprt mutant frequencies in BD-diol exposed rodents, indicating that EB-diol was involved in the mutagenic response associated with BD-diol exposure." | ( The importance of 3,4-epoxy-1,2-butanediol and hydroxymethylvinyl ketone in 3-butene-1,2-diol associated mutagenicity. Li, Y; Powley, MW; Swenberg, JA; Upton, PB; Walker, VE, 2007) | 0.34 |
| " In the present study, we used multiple mass spectrometry techniques to investigate the formation of HMVK adducts with nucleophilic residues of Hb in vivo after dosing Sprague-Dawley rats with 25 and 200 mg/kg BDD." | ( Mass spectral analyses of hydroxymethylvinyl ketone-hemoglobin adducts formed after in vivo exposure of Sprague-Dawley rats to 3-butene-1,2-diol. Barshteyn, N; Elfarra, AA, 2009) | 0.35 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (28.00) | 18.2507 |
| 2000's | 15 (60.00) | 29.6817 |
| 2010's | 2 (8.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.17) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (3.85%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 25 (96.15%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||