Compounds > 3,4-epoxybutane-1,2-diol
Page last updated: 2024-09-02

3,4-epoxybutane-1,2-diol and diepoxybutane

3,4-epoxybutane-1,2-diol has been researched along with diepoxybutane in 13 studies

Compound Research Comparison

Studies
(3,4-epoxybutane-1,2-diol)		Trials
(3,4-epoxybutane-1,2-diol)		Recent Studies (post-2010)
(3,4-epoxybutane-1,2-diol)		Studies
(diepoxybutane)		Trials
(diepoxybutane)		Recent Studies (post-2010) (diepoxybutane)
2603382339

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (46.15)18.2507
2000's6 (46.15)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lähdetie, J; Sjöblom, T1
Lähdetie, J; Peltonen, K; Sjöblom, T1
Grawé, J; Lähdetie, J1
Kilpeläinen, I; Koivisto, P; Lähdetie, J; Landin, H; Osterman-Golkar, S; Peltonen, K; Pérez, HL1
Adler, ID; Kliesch, U; Nylund, L; Peltonen, K1
Adler, ID; Kilpeläinen, I; Koivisto, P; Pacchierotti, F; Peltonen, K; Rasanen, I1
Jackson, MA; Rice, JM; Stack, HF; Waters, MD1
Erexson, GL; Tindall, KR1
Bhowmik, S; Csanády, GA; Faller, TH; Filser, JG; Kessler, W; Pütz, C; Schuster, A1
Kim, HJ; Kim, TH; Lee, CS; Lee, DH; Lee, SY; Pfeifer, GP; Rhee, SK; Yoon, B1
Csanády, GA; Filser, JG; Hutzler, C; Meischner, V; Veereshwarayya, V1
Bois, FY; Brochot, C; Smith, TJ1
An, J; Wen, Y; Wu, MH; Yu, YX; Zhang, PP; Zhang, XY1

Reviews

1 review(s) available for 3,4-epoxybutane-1,2-diol and diepoxybutane

ArticleYear
A review of the genetic and related effects of 1,3-butadiene in rodents and humans.
    Mutation research, 2000, Volume: 463, Issue:3

    Topics: Air Pollutants, Occupational; Alkylating Agents; Animals; Aryl Hydrocarbon Hydroxylases; Biomarkers; Biotransformation; Butadienes; Carcinogens; Cytochrome P-450 CYP2A6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA; DNA Adducts; DNA Damage; Epoxy Compounds; Female; Glycols; Hemoglobins; Humans; Inactivation, Metabolic; Male; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; Mutagenesis; Mutagenicity Tests; Mutagens; Neoplasms, Experimental; Occupational Exposure; Organ Specificity; Oxidation-Reduction; Proteins; Rats; Rats, Sprague-Dawley; Single-Blind Method; Sister Chromatid Exchange; Species Specificity

2000

Other Studies

12 other study(ies) available for 3,4-epoxybutane-1,2-diol and diepoxybutane

ArticleYear
Micronuclei are induced in rat spermatids in vitro by 1,2,3,4-diepoxybutane but not by 1,2-epoxy-3-butene and 1,2-dihydroxy-3,4-epoxybutane.
    Mutagenesis, 1996, Volume: 11, Issue:5

    Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Epoxy Compounds; Glycols; Male; Meiosis; Micronucleus Tests; Mutagens; Rats; Rats, Sprague-Dawley; Spermatids

1996
Germ cell mutagenicity of three metabolites of 1,3-butadiene in the rat: induction of spermatid micronuclei by butadiene mono-, di-, and diolepoxides in vivo.
    Environmental and molecular mutagenesis, 1997, Volume: 29, Issue:3

    Topics: Animals; Body Weight; Butadienes; Cell Survival; DNA Replication; Epoxy Compounds; Glycols; Male; Micronucleus Tests; Mutagens; Organ Size; Rats; Rats, Sprague-Dawley; Spermatids; Testis

1997
Flow cytometric analysis of micronucleus induction in rat bone marrow polychromatic erythrocytes by 1,2;3,4-diepoxybutane, 3,4-epoxy-1-butene, and 1,2-epoxybutane-3,4-diol.
    Cytometry, 1997, Jul-01, Volume: 28, Issue:3

    Topics: Animals; Benzimidazoles; Bone Marrow Cells; Cell Separation; Epoxy Compounds; Erythrocyte Aging; Erythrocytes; Flow Cytometry; Fluorescent Dyes; Glycols; Male; Mice; Micronucleus Tests; Mutagens; Rats; Rats, Sprague-Dawley

1997
Haemoglobin adducts of epoxybutanediol from exposure to 1,3-butadiene or butadiene epoxides.
    Chemico-biological interactions, 1997, Aug-01, Volume: 105, Issue:3

    Topics: Air Pollutants, Occupational; Animals; Butadienes; Epoxy Compounds; Gas Chromatography-Mass Spectrometry; Glycols; Hemoglobins; Humans; Magnetic Resonance Spectroscopy; Male; Micronucleus Tests; Rats; Rats, Sprague-Dawley; Rats, Wistar; Valine

1997
In vitro and in vivo mutagenicity of the butadiene metabolites butadiene diolepoxide, butadiene monoepoxide and diepoxybutane.
    Mutagenesis, 1997, Volume: 12, Issue:5

    Topics: Animals; Bone Marrow Cells; Butadienes; Crosses, Genetic; Epoxy Compounds; Female; Fetal Death; Genes, Lethal; Glycols; Litter Size; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Micronucleus Tests; Mutagenicity Tests; Mutagens; Pregnancy; Salmonella typhimurium; Structure-Activity Relationship

1997
Butadiene diolepoxide- and diepoxybutane-derived DNA adducts at N7-guanine: a high occurrence of diolepoxide-derived adducts in mouse lung after 1,3-butadiene exposure.
    Carcinogenesis, 1999, Volume: 20, Issue:7

    Topics: Animals; Butadienes; Cell Line; Chromatography, High Pressure Liquid; DNA Adducts; Dose-Response Relationship, Drug; Epoxy Compounds; Glycols; Guanine; Humans; Inhalation Exposure; Lung; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Conformation; Molecular Structure; Phosphorus Radioisotopes

1999
Micronuclei and gene mutations in transgenic big Blue((R)) mouse and rat fibroblasts after exposure to the epoxide metabolites of 1, 3-butadiene.
    Mutation research, 2000, Dec-20, Volume: 472, Issue:1-2

    Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Apoptosis; Biotransformation; Butadienes; Cell Survival; Cells, Cultured; Epoxy Compounds; Fibroblasts; Glycols; Humans; Mice; Mice, Transgenic; Micronuclei, Chromosome-Defective; Micronucleus Tests; Mutagenicity Tests; Rats; Rats, Mutant Strains

2000
First-pass metabolism of 1,3-butadiene in once-through perfused livers of rats and mice.
    Chemico-biological interactions, 2001, Jun-01, Volume: 135-136

    Topics: Aldehydes; Animals; Biotransformation; Butadienes; Epoxy Compounds; Glycols; Kinetics; Liver; Male; Mice; Perfusion; Rats; Rats, Sprague-Dawley; Species Specificity

2001
Mutations induced by 1,3-butadiene metabolites, butadiene diolepoxide, and 1,2,3,4-diepoxybutane at the Hprt locus in CHO-K1 cells.
    Molecules and cells, 2002, Dec-31, Volume: 14, Issue:3

    Topics: Animals; Butadienes; Carcinogens; Cell Survival; CHO Cells; Cricetinae; DNA Adducts; DNA Damage; DNA Mutational Analysis; DNA Primers; Epoxy Compounds; Exons; Formazans; Glycols; Hypoxanthine Phosphoribosyltransferase; Mutagenesis; Mutagens; Mutation; Polymerase Chain Reaction; Sequence Deletion; Tetrazolium Salts

2002
Metabolism of 1,3-butadiene to toxicologically relevant metabolites in single-exposed mice and rats.
    Chemico-biological interactions, 2007, Mar-20, Volume: 166, Issue:1-3

    Topics: Animals; Biotransformation; Butadienes; Epoxy Compounds; Glycols; Inhalation Exposure; Male; Mice; Rats; Rats, Sprague-Dawley; Time Factors

2007
Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: global sensitivity analysis for experimental design issues.
    Chemico-biological interactions, 2007, May-01, Volume: 167, Issue:3

    Topics: Administration, Inhalation; Adult; Biotransformation; Body Fluid Compartments; Breath Tests; Butadienes; Butylene Glycols; Epoxy Compounds; Glycols; Humans; Kinetics; Male; Models, Biological; Reference Values; Sensitivity and Specificity; Software; Time Factors

2007
DNA damage induced by three major metabolites of 1,3-butadiene in human hepatocyte L02 cells.
    Mutation research, 2012, Sep-18, Volume: 747, Issue:2

    Topics: Butadienes; Butylene Glycols; Carcinogens; Cell Line, Transformed; Comet Assay; DNA Breaks, Single-Stranded; DNA Damage; Epoxy Compounds; Hepatocytes; Humans; Mutagens

2012