Compounds > 3'-uridylic acid
Page last updated: 2024-12-07

3'-uridylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

UMP is a nucleotide that serves as a building block for RNA. It consists of the pyrimidine base uracil attached to a ribose sugar, which is then linked to a phosphate group at the 3' carbon of the ribose. UMP plays a crucial role in numerous metabolic processes, including RNA synthesis, energy metabolism, and the biosynthesis of other nucleotides. It is also an essential component of the genetic code. In research, UMP is studied for its involvement in a range of biological processes, such as gene expression, cell signaling, and the regulation of metabolism. The synthesis of UMP occurs through the salvage pathway, where pre-existing uracil is converted to UMP. Alternatively, UMP can be synthesized de novo from the precursor orotate. UMP can be phosphorylated to form UDP and UTP, which are also important nucleotides involved in various metabolic pathways.'

3'-uridylic acid: structure in first source; main heading URIDINE MONOPHOSPHATE refers to 5'-uridylic acid [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

3'-UMP : A pyrimidine ribonucleoside 3'-monophosphate having uracil as the nucleobase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID101543
CHEMBL ID460741
CHEBI ID28895
SCHEMBL ID345577
MeSH IDM0097815

Synonyms (27)

Synonym
3'-uridylic acid
CHEBI:28895 ,
u3p ,
3'-uridinemonophosphate
uridine 3'-phosphate
C01368
3'-ump
uridine 3'-monophosphate
DB02714
4RSK
1O0N
CHEMBL460741 ,
[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate
3''-uridylic acid
3''-ump
bdbm50292722
uridine 3'-(dihydrogen phosphate)
einecs 201-538-0
unii-zi74vyb8vz
zi74vyb8vz ,
SCHEMBL345577
uracylsaure
uridine-3'-phosphate
Q27103948
DTXSID401018973
3-umpna
PD042601
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
uridine phosphate
pyrimidine ribonucleoside 3'-monophosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (11)

PathwayProteinsCompounds
Pyrimidine Ribonucleosides Degradation511
Disease1278231
Infectious disease89579
SARS-CoV Infections28229
SARS-CoV-1 Infection11422
SARS-CoV-2 Infection19527
SARS-CoV-2 Genome Replication and Transcription710
Replication of the SARS-CoV-2 genome59
Early SARS-CoV-2 Infection Events2811
SARS-CoV-1 activates/modulates innate immune responses414
Viral Infection Pathways72739

Protein Targets (8)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Ribonuclease pancreaticBos taurus (cattle)Ki82.00001.200024.050082.0000AID977610
Chain A, Ribonuclease pancreaticBos taurus (cattle)Ki82.00001.200024.050082.0000AID977610
Chain A, Ribonuclease pancreaticBos taurus (cattle)Ki82.00001.200024.050082.0000AID977610
Chain A, Ribonuclease pancreaticBos taurus (cattle)Ki82.00001.200024.050082.0000AID977610
Chain A, Ribonuclease pancreaticBos taurus (cattle)Ki82.00001.200024.050082.0000AID977610
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Ribonuclease ABos taurus (cattle)Kd47.400047.400047.400047.4000AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (1)

Processvia Protein(s)Taxonomy
defense response to virusSeminal ribonucleaseBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Processvia Protein(s)Taxonomy
nucleic acid bindingSeminal ribonucleaseBos taurus (cattle)
ribonuclease A activitySeminal ribonucleaseBos taurus (cattle)
RNA nuclease activitySeminal ribonucleaseBos taurus (cattle)
lyase activitySeminal ribonucleaseBos taurus (cattle)
identical protein bindingSeminal ribonucleaseBos taurus (cattle)
nucleic acid bindingRibonuclease pancreaticBos taurus (cattle)
ribonuclease A activityRibonuclease pancreaticBos taurus (cattle)
protein bindingRibonuclease pancreaticBos taurus (cattle)
lyase activityRibonuclease pancreaticBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
extracellular regionSeminal ribonucleaseBos taurus (cattle)
extracellular regionRibonuclease pancreaticBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID469231Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 62009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID469230Inhibition of bovine seminal ribonuclease assessed as enzyme activity by spectrophotometric method at pH 62009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID345848Inhibition of bovine pancreatic RNase A by spectrophotometric method2009Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4
Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation.
AID1811Experimentally measured binding affinity data derived from PDB1998Biochemistry, Dec-15, Volume: 37, Issue:50
Coulombic effects of remote subsites on the active site of ribonuclease A.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB1998Biochemistry, Dec-15, Volume: 37, Issue:50
Coulombic effects of remote subsites on the active site of ribonuclease A.
AID1811Experimentally measured binding affinity data derived from PDB2003Protein science : a publication of the Protein Society, Nov, Volume: 12, Issue:11
High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2003Protein science : a publication of the Protein Society, Nov, Volume: 12, Issue:11
High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (16.67)18.7374
1990's1 (8.33)18.2507
2000's5 (41.67)29.6817
2010's3 (25.00)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.38 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.94 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-aminobenzamidine
4-aminobenzamidine: a urokinase inhibitor; inhibits acrosin; structure given in first source		2.2510
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		210
alanine
Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.		2.420alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid		EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite
lysine
Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.		1.9910aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid		algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
adenosine diphosphate
Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.		2.0110adenosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate		fundamental metabolite;
human metabolite
uridine monophosphate
Uridine Monophosphate: 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.. uridine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having uracil as the nucleobase.		3.6190pyrimidine ribonucleoside 5'-monophosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
uridine diphosphate
Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.		2.0510pyrimidine ribonucleoside 5'-diphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
cytidine monophosphate
Cytidine Monophosphate: Cytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.. cytidine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.		2.0510cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-monophosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		2.420amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		1.9910arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
trimethyl phosphate
trimethyl phosphate: request from searcher; structure. trimethyl phosphate : A trialkyl phosphate that is the trimethyl ester of phosphoric acid.		2.1310trialkyl phosphateinsect attractant;
NMR chemical shift reference compound
3'-cmp
3'-CMP : A cytidine 3'-phosphate compound with a monophosphate group at the 3'-position.		2.4520cytidine 3'-phosphate;
pyrimidine ribonucleoside 3'-monophosphate		Escherichia coli metabolite;
metabolite;
mouse metabolite
6-carboxyfluorescein
6-carboxyfluorescein: originally sold as 6-carboxyfluorescein, but commercial product is a mixture of two isomers; correct name is 5(6)-carboxyfluorescein		210monocarboxylic acid
adenosine 3'-phosphate-5'-phosphate
adenosine 3',5'-bismonophosphate : An adenosine bisphosphate having two monophosphate groups at the 3'- and 5'-positions.		2.0110adenosine bisphosphateEscherichia coli metabolite;
mouse metabolite
adenosine 2',5'-diphosphate
[no description available]		2.0110
oligonucleotides
[no description available]		7.6530
uridine diphosphate
UDP(3-) : A nucleoside 5'-diphosphate(3-) arising from deprotonation of the diphosphate OH groups of uridine 5'-diphosphate (UDP); major species at pH 7.3.		2.0510nucleoside 5'-diphosphate(3-)human metabolite;
Saccharomyces cerevisiae metabolite
muramidase
Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.		2.2510
ConditionIndicatedRelationship StrengthStudiesTrials
Angiogenesis, Pathologic
[description not available]		02.0510
Fetal Macrosomia
A condition of fetal overgrowth leading to a large-for-gestational-age FETUS. It is defined as BIRTH WEIGHT greater than 4,000 grams or above the 90th percentile for population and sex-specific growth curves. It is commonly seen in GESTATIONAL DIABETES; PROLONGED PREGNANCY; and pregnancies complicated by pre-existing diabetes mellitus.		02.0810
Bilateral Wilms Tumor
[description not available]		02.0810
Wilms Tumor
A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.		02.0810