Compounds > 3'-uridylic acid

Page last updated: 2024-12-07

3'-uridylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

UMP is a nucleotide that serves as a building block for RNA. It consists of the pyrimidine base uracil attached to a ribose sugar, which is then linked to a phosphate group at the 3' carbon of the ribose. UMP plays a crucial role in numerous metabolic processes, including RNA synthesis, energy metabolism, and the biosynthesis of other nucleotides. It is also an essential component of the genetic code. In research, UMP is studied for its involvement in a range of biological processes, such as gene expression, cell signaling, and the regulation of metabolism. The synthesis of UMP occurs through the salvage pathway, where pre-existing uracil is converted to UMP. Alternatively, UMP can be synthesized de novo from the precursor orotate. UMP can be phosphorylated to form UDP and UTP, which are also important nucleotides involved in various metabolic pathways.'

3'-uridylic acid: structure in first source; main heading URIDINE MONOPHOSPHATE refers to 5'-uridylic acid [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

3'-UMP : A pyrimidine ribonucleoside 3'-monophosphate having uracil as the nucleobase. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	101543
CHEMBL ID	460741
CHEBI ID	28895
SCHEMBL ID	345577
MeSH ID	M0097815

Synonyms (27)

Synonym
3'-uridylic acid
CHEBI:28895 ,
u3p ,
3'-uridinemonophosphate
uridine 3'-phosphate
C01368
3'-ump
uridine 3'-monophosphate
DB02714
4RSK
1O0N
CHEMBL460741 ,
[(2r,3s,4r,5r)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate
3''-uridylic acid
3''-ump
bdbm50292722
uridine 3'-(dihydrogen phosphate)
einecs 201-538-0
unii-zi74vyb8vz
zi74vyb8vz ,
SCHEMBL345577
uracylsaure
uridine-3'-phosphate
Q27103948
DTXSID401018973
3-umpna
PD042601

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

Role	Description
Escherichia coli metabolite	Any bacterial metabolite produced during a metabolic reaction in Escherichia coli.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

Class	Description
uridine phosphate
pyrimidine ribonucleoside 3'-monophosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (11)

Pathway	Proteins	Compounds
Pyrimidine Ribonucleosides Degradation	5	11
Disease	1278	231
Infectious disease	895	79
SARS-CoV Infections	282	29
SARS-CoV-1 Infection	114	22
SARS-CoV-2 Infection	195	27
SARS-CoV-2 Genome Replication and Transcription	7	10
Replication of the SARS-CoV-2 genome	5	9
Early SARS-CoV-2 Infection Events	28	11
SARS-CoV-1 activates/modulates innate immune responses	41	4
Viral Infection Pathways	727	39

Protein Targets (8)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Ribonuclease pancreatic	Bos taurus (cattle)	Ki	82.0000	1.2000	24.0500	82.0000	AID977610
Chain A, Ribonuclease pancreatic	Bos taurus (cattle)	Ki	82.0000	1.2000	24.0500	82.0000	AID977610
Chain A, Ribonuclease pancreatic	Bos taurus (cattle)	Ki	82.0000	1.2000	24.0500	82.0000	AID977610
Chain A, Ribonuclease pancreatic	Bos taurus (cattle)	Ki	82.0000	1.2000	24.0500	82.0000	AID977610
Chain A, Ribonuclease pancreatic	Bos taurus (cattle)	Ki	82.0000	1.2000	24.0500	82.0000	AID977610
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Ribonuclease A	Bos taurus (cattle)	Kd	47.4000	47.4000	47.4000	47.4000	AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (1)

Process	via Protein(s)	Taxonomy
defense response to virus	Seminal ribonuclease	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Process	via Protein(s)	Taxonomy
nucleic acid binding	Seminal ribonuclease	Bos taurus (cattle)
ribonuclease A activity	Seminal ribonuclease	Bos taurus (cattle)
RNA nuclease activity	Seminal ribonuclease	Bos taurus (cattle)
lyase activity	Seminal ribonuclease	Bos taurus (cattle)
identical protein binding	Seminal ribonuclease	Bos taurus (cattle)
nucleic acid binding	Ribonuclease pancreatic	Bos taurus (cattle)
ribonuclease A activity	Ribonuclease pancreatic	Bos taurus (cattle)
protein binding	Ribonuclease pancreatic	Bos taurus (cattle)
lyase activity	Ribonuclease pancreatic	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (1)

Process	via Protein(s)	Taxonomy
extracellular region	Seminal ribonuclease	Bos taurus (cattle)
extracellular region	Ribonuclease pancreatic	Bos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (7)

Assay ID	Title	Year	Journal	Article
AID469231	Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 6	2009	European journal of medicinal chemistry, Nov, Volume: 44, Issue:11	Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID469230	Inhibition of bovine seminal ribonuclease assessed as enzyme activity by spectrophotometric method at pH 6	2009	European journal of medicinal chemistry, Nov, Volume: 44, Issue:11	Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID345848	Inhibition of bovine pancreatic RNase A by spectrophotometric method	2009	Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4	Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation.
AID1811	Experimentally measured binding affinity data derived from PDB	1998	Biochemistry, Dec-15, Volume: 37, Issue:50	Coulombic effects of remote subsites on the active site of ribonuclease A.
AID977611	Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB	1998	Biochemistry, Dec-15, Volume: 37, Issue:50	Coulombic effects of remote subsites on the active site of ribonuclease A.
AID1811	Experimentally measured binding affinity data derived from PDB	2003	Protein science : a publication of the Protein Society, Nov, Volume: 12, Issue:11	High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors.
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2003	Protein science : a publication of the Protein Society, Nov, Volume: 12, Issue:11	High-resolution crystal structures of ribonuclease A complexed with adenylic and uridylic nucleotide inhibitors. Implications for structure-based design of ribonucleolytic inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (16.67)	18.7374
1990's	1 (8.33)	18.2507
2000's	5 (41.67)	29.6817
2010's	3 (25.00)	24.3611
2020's	1 (8.33)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.38

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.38 (24.57)
Research Supply Index	2.56 (2.92)
Research Growth Index	4.94 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.38)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	12 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
4-aminobenzamidine 4-aminobenzamidine: a urokinase inhibitor; inhibits acrosin; structure given in first source	2.25	1
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	2	1
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	2.4	2	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	1.99	1	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
adenosine diphosphate Adenosine Diphosphate: Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position.	2.01	1	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite
uridine monophosphate Uridine Monophosphate: 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.. uridine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having uracil as the nucleobase.	3.61	9	pyrimidine ribonucleoside 5'-monophosphate; uridine 5'-phosphate	Escherichia coli metabolite; human metabolite; mouse metabolite
uridine diphosphate Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.	2.05	1	pyrimidine ribonucleoside 5'-diphosphate; uridine 5'-phosphate	Escherichia coli metabolite; mouse metabolite
cytidine monophosphate Cytidine Monophosphate: Cytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.. cytidine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.	2.05	1	cytidine 5'-phosphate; pyrimidine ribonucleoside 5'-monophosphate	Escherichia coli metabolite; human metabolite; mouse metabolite
histidine Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.	2.4	2	amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	1.99	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
trimethyl phosphate trimethyl phosphate: request from searcher; structure. trimethyl phosphate : A trialkyl phosphate that is the trimethyl ester of phosphoric acid.	2.13	1	trialkyl phosphate	insect attractant; NMR chemical shift reference compound
3'-cmp 3'-CMP : A cytidine 3'-phosphate compound with a monophosphate group at the 3'-position.	2.45	2	cytidine 3'-phosphate; pyrimidine ribonucleoside 3'-monophosphate	Escherichia coli metabolite; metabolite; mouse metabolite
6-carboxyfluorescein 6-carboxyfluorescein: originally sold as 6-carboxyfluorescein, but commercial product is a mixture of two isomers; correct name is 5(6)-carboxyfluorescein	2	1	monocarboxylic acid
adenosine 3'-phosphate-5'-phosphate adenosine 3',5'-bismonophosphate : An adenosine bisphosphate having two monophosphate groups at the 3'- and 5'-positions.	2.01	1	adenosine bisphosphate	Escherichia coli metabolite; mouse metabolite
adenosine 2',5'-diphosphate [no description available]	2.01	1
oligonucleotides [no description available]	7.65	3
uridine diphosphate UDP(3-) : A nucleoside 5'-diphosphate(3-) arising from deprotonation of the diphosphate OH groups of uridine 5'-diphosphate (UDP); major species at pH 7.3.	2.05	1	nucleoside 5'-diphosphate(3-)	human metabolite; Saccharomyces cerevisiae metabolite
muramidase Muramidase: A basic enzyme that is present in saliva, tears, egg white, and many animal fluids. It functions as an antibacterial agent. The enzyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrin. EC 3.2.1.17.	2.25	1

Condition	Relationship Strength	Studies
Angiogenesis, Pathologic [description not available]	2.05	1
Fetal Macrosomia A condition of fetal overgrowth leading to a large-for-gestational-age FETUS. It is defined as BIRTH WEIGHT greater than 4,000 grams or above the 90th percentile for population and sex-specific growth curves. It is commonly seen in GESTATIONAL DIABETES; PROLONGED PREGNANCY; and pregnancies complicated by pre-existing diabetes mellitus.	2.08	1
Bilateral Wilms Tumor [description not available]	2.08	1
Wilms Tumor A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.	2.08	1

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