Compounds > 3'-cmp
Page last updated: 2024-11-06

3'-cmp

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Description

3'-CMP : A cytidine 3'-phosphate compound with a monophosphate group at the 3'-position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID66535
CHEMBL ID258728
CHEBI ID53013
SCHEMBL ID79966
MeSH IDM0005574

Synonyms (48)

Synonym
3'-cmp
84-52-6
C05822
cytidine 3'-phosphate
DB01961
cytidine 3'-monophosphate
3'-cytidylic acid
C3P ,
cytidine-3'-monophosphate
NCGC00142494-01
CHEBI:53013 ,
[(2s,3s,4r,5r)-5-(4-amino-2-oxo-pyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxola
uooopkaniplqpu-xvfcmesisa-
inchi=1/c9h14n3o8p/c10-5-1-2-12(9(15)11-5)8-6(14)7(4(3-13)19-8)20-21(16,17)18/h1-2,4,6-8,13-14h,3h2,(h2,10,11,15)(h2,16,17,18)/t4-,6-,7-,8-/m1/s1
CHEMBL258728 ,
[(2r,3s,4r,5r)-5-(4-amino-2-oxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] dihydrogen phosphate
bdbm50233301
cytidine-3''-monophosphate
(2r,3s,4r,5r)-5-(4-amino-2-oxopyrimidin-1(2h)-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl dihydrogen phosphate
A840831
(3s,2r,4r,5r)-5-(4-amino-2-oxohydropyrimidinyl)-4-hydroxy-2-(hydroxymethyl)oxo lan-3-yl dihydrogen phosphate
ST057096
6dzl5i6d4d ,
unii-6dzl5i6d4d
einecs 201-537-5
S10910
AKOS015895646
AKOS015856718
SCHEMBL79966
cytidine, 3'-phosphate
cytidylic acid b
3'-cytidylic acid [mi]
3'-cytidinephosphoric acid
ribocytidine 3'-monophosphate
UOOOPKANIPLQPU-XVFCMESISA-N
3-cytidylic acid
cytidine3'-monophosphate
[(2r,3s,4r,5r)-5-(4-amino-2-keto-pyrimidin-1-yl)-4-hydroxy-2-methylol-tetrahydrofuran-3-yl] dihydrogen phosphate
[(2r,3s,4r,5r)-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-2-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl] dihydrogen phosphate
mfcd00006543
cytidine-3'-phosphate
cytidine 3-monophosphate
cytidylsa currencyure b
Q27104806
4-imino-1-(3-o-phosphonopentofuranosyl)-1,4-dihydropyrimidin-2-ol
DTXSID301004260
cytidine-3/'-monophosphate
(2r,3s,4r,5r)-5-(4-amino-2-oxopyrimidin-1(2h)-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yldihydrogenphosphate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
cytidine 3'-phosphate
pyrimidine ribonucleoside 3'-monophosphate
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (21)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency70.79460.010039.53711,122.0200AID1469
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency7.94330.031610.279239.8107AID884; AID885
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
GABA theta subunitRattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency7.94331.000012.224831.6228AID885
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (2)

Processvia Protein(s)Taxonomy
defense response to virusSeminal ribonucleaseBos taurus (cattle)
defense response to virusRibonuclease pancreaticHomo sapiens (human)
defense response to Gram-positive bacteriumRibonuclease pancreaticHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (6)

Processvia Protein(s)Taxonomy
nucleic acid bindingSeminal ribonucleaseBos taurus (cattle)
ribonuclease A activitySeminal ribonucleaseBos taurus (cattle)
RNA nuclease activitySeminal ribonucleaseBos taurus (cattle)
lyase activitySeminal ribonucleaseBos taurus (cattle)
identical protein bindingSeminal ribonucleaseBos taurus (cattle)
nucleic acid bindingRibonuclease pancreaticHomo sapiens (human)
ribonuclease A activityRibonuclease pancreaticHomo sapiens (human)
RNA nuclease activityRibonuclease pancreaticHomo sapiens (human)
protein bindingRibonuclease pancreaticHomo sapiens (human)
lyase activityRibonuclease pancreaticHomo sapiens (human)
nucleic acid bindingRibonuclease pancreaticBos taurus (cattle)
ribonuclease A activityRibonuclease pancreaticBos taurus (cattle)
protein bindingRibonuclease pancreaticBos taurus (cattle)
lyase activityRibonuclease pancreaticBos taurus (cattle)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
extracellular regionSeminal ribonucleaseBos taurus (cattle)
extracellular exosomeRibonuclease pancreaticHomo sapiens (human)
plasma membraneGamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)
extracellular regionRibonuclease pancreaticBos taurus (cattle)
plasma membraneGamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID323778Inhibition of RNase A assessed as tRNA degradation by agarose-gel based assay2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Exploring the potential of 3'-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin.
AID469225Inhibition of aspermatogenic activity of bovine seminal ribonuclease in mouse ICR assessed as width of spermatogenic layer at 1:100 ratio of BS-Rnase+compound after 10 days administered once into left testes2009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID323779Inhibition of RNase A at 0.22 mM by precipitation assay2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Exploring the potential of 3'-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin.
AID323781Activity at RNase A2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Exploring the potential of 3'-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin.
AID469230Inhibition of bovine seminal ribonuclease assessed as enzyme activity by spectrophotometric method at pH 62009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID502270Inhibition of RNase A-mediated degradation of yeast tRNA assessed as residual tRNA band by agarose gel electrophoresis relative to control2010Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17
Synthesis and ribonuclease A inhibition activity of resorcinol and phloroglucinol derivatives of catechin and epicatechin: Importance of hydroxyl groups.
AID469231Inhibition of bovine pancreatic ribonuclease A assessed as enzyme activity by spectrophotometric method pH 62009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID469229Inhibition of aspermatogenic activity of bovine seminal ribonuclease in mouse ICR assessed as weight of the testes at 1:1 ratio of BS-Rnase+compound after 10 days administered once into left testes2009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID469226Inhibition of aspermatogenic activity of bovine seminal ribonuclease in mouse ICR assessed as width of spermatogenic layer at 1:1 ratio of BS-Rnase+compound after 10 days administered once into left testes2009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID436843Inhibition of bovine pancreatic RNase A by spectrophotometric assay2009Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14
Nucleoside-amino acid conjugates: An alternative route to the design of ribonuclease A inhibitors.
AID323780Inhibition of RNase A by precipitation assay2008Bioorganic & medicinal chemistry, Mar-15, Volume: 16, Issue:6
Exploring the potential of 3'-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin.
AID469222Inhibition of aspermatogenic activity of bovine seminal ribonuclease in mouse ICR assessed as diameter of somniferous tubule at 1:100 ratio of BS-Rnase+compound after 10 days administered once into left testes2009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID345848Inhibition of bovine pancreatic RNase A by spectrophotometric method2009Journal of medicinal chemistry, Feb-26, Volume: 52, Issue:4
Morpholino, piperidino, and pyrrolidino derivatives of pyrimidine nucleosides as inhibitors of ribonuclease A: synthesis, biochemical, and crystallographic evaluation.
AID469223Inhibition of aspermatogenic activity of bovine seminal ribonuclease in mouse ICR assessed as diameter of somniferous tubule at 1:1 ratio of BS-Rnase+compound after 10 days administered once into left testes2009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
AID469227Inhibition of aspermatogenic activity of bovine seminal ribonuclease in mouse ICR assessed as weight of the testes at 1:100 ratio of BS-Rnase+compound after 10 days administered once into left testes2009European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
Mapping the ribonucleolytic active site of bovine seminal ribonuclease. The binding of pyrimidinyl phosphonucleotide inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index25.67 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.28 (4.65)
Search Engine Demand Index26.67 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (25.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
catechin
[no description available]		2.0510hydroxyflavan
uridine diphosphate
Uridine Diphosphate: A uracil nucleotide containing a pyrophosphate group esterified to C5 of the sugar moiety.		2.0510pyrimidine ribonucleoside 5'-diphosphate;
uridine 5'-phosphate		Escherichia coli metabolite;
mouse metabolite
cytidine monophosphate
Cytidine Monophosphate: Cytidine (dihydrogen phosphate). A cytosine nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.. cytidine 5'-monophosphate : A pyrimidine ribonucleoside 5'-monophosphate having cytosine as the nucleobase.		2.0510cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-monophosphate		Escherichia coli metabolite;
human metabolite;
mouse metabolite
epicatechin
(-)-epicatechin : A catechin with (2R,3R)-configuration.		2.0510catechin;
polyphenol		antioxidant
3'-uridylic acid
3'-uridylic acid: structure in first source; main heading URIDINE MONOPHOSPHATE refers to 5'-uridylic acid. 3'-UMP : A pyrimidine ribonucleoside 3'-monophosphate having uracil as the nucleobase.		2.4520pyrimidine ribonucleoside 3'-monophosphate;
uridine phosphate		Escherichia coli metabolite
uridine diphosphate
UDP(3-) : A nucleoside 5'-diphosphate(3-) arising from deprotonation of the diphosphate OH groups of uridine 5'-diphosphate (UDP); major species at pH 7.3.		2.0510nucleoside 5'-diphosphate(3-)human metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Angiogenesis, Pathologic
[description not available]		02.0510