Compounds > chaetoviridin a
Page last updated: 2024-12-11

chaetoviridin a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

chaetoviridin A: from Chaetomium globosum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

chaetoviridin A : An azaphilone that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a chloro group at position 5, a 3-hydroxy-2-methylbutanoyl group at position 9, a methyl group at position 6a and a 3-methylpent-1-en-1yl group at position 3. Isolated from Chaetomium globosum, it exhibits natifungal activity against plant pathogenic fungi. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID6450533
CHEMBL ID1802150
CHEBI ID67610
MeSH IDM0582510

Synonyms (13)

Synonym
6h-furo[2,3-h]-2-benzopyran-6,8(6ah)-dione, 5-chloro-9-[(2s,3r)-3-hydroxy-20methyl-1-oxobutyl]-6a-methyl-3-[(1e,3s)-3-methyl-1-pentenyl)-,(6as)
(6as)-5-chloro-9-[(2s,3r)-3-hydroxy-2-methyl-butanoyl]-6a-methyl-3-[(e,3s)-3-methylpent-1-enyl]furo[2,3-h]isochromene-6,8-dione
chaetoviridin a
128252-98-2
(6as)-5-chloro-9-[(2s,3r)-3-hydroxy-2-methylbutanoyl]-6a-methyl-3-[(e,3s)-3-methylpent-1-enyl]furo[2,3-h]isochromene-6,8-dione
chebi:67610 ,
CHEMBL1802150
ccris 7226
(6as)-5-chloro-9-[(2s,3r)-3-hydroxy-2-methylbutanoyl]-6a-methyl-3-[(1e,3s)-3-methylpent-1-en-1-yl]-6h-furo[2,3-h]isochromene-6,8(6ah)-dione
HB3829
J-005582
DTXSID80893270
Q27136080
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
antifungal agentAn antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
Chaetomium metaboliteAny fungal metabolite produced during a metabolic reaction in the mould, Chaetomium.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (7)

ClassDescription
azaphiloneAny member of a family of natural products which contains a 6H-isochromene-6,8(7H)-dione or an isoquinoline-6,8(2H,7H)-dione skeleton and its substituted derivatives thereof.
gamma-lactoneA lactone having a five-membered lactone ring.
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
enoneAn alpha,beta-unsaturated ketone of general formula R(1)R(2)C=CR(3)-C(=O)R(4) (R(4) =/= H) in which the C=O function is conjugated to a C=C double bond at the alpha,beta position.
secondary alcoholA secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
beta-hydroxy ketoneA ketone containing a hydroxy group on the beta-carbon relative to the C=O group.
organic heterotricyclic compoundAn organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID1651829Cytotoxicity against human AGS cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay2020Journal of natural products, 04-24, Volume: 83, Issue:4
Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus
AID606811Antibiotic activity against cytolysin-positive Enterococcus faecalis MMH594 infected in intestine of Caenorhabditis elegans glp-4(bn2ts);sek-1(km4) mutant infection model assessed as nematode survival at 50 to 100 ug/mL after 168 hrs by liquid infection a2011Journal of natural products, May-27, Volume: 74, Issue:5
Azaphilones from the endophyte Chaetomium globosum.
AID1651828Cytotoxicity against human MGC803 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay2020Journal of natural products, 04-24, Volume: 83, Issue:4
Cytotoxic Nitrogenated Azaphilones from the Deep-Sea-Derived Fungus
AID606813Antimicrobial activity against Magnaporthe grisea mycelia assessed as growth inhibition2011Journal of natural products, May-27, Volume: 74, Issue:5
Azaphilones from the endophyte Chaetomium globosum.
AID606812Antimicrobial activity against Pythium ultimum mycelia assessed as growth inhibition2011Journal of natural products, May-27, Volume: 74, Issue:5
Azaphilones from the endophyte Chaetomium globosum.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.63 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.57 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pargyline
Pargyline: A monoamine oxidase inhibitor with antihypertensive properties.		2.0810aromatic amine
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.2510taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
4'-epichaetoviridin A
4'-epichaetoviridin A : An azaphilone that is the 4'-epimer of chaetoviridin A. It has been isolated from Chaetomium globosum.		2.0610azaphilone;
beta-hydroxy ketone;
enone;
gamma-lactone;
organic heterotricyclic compound;
organochlorine compound;
secondary alcohol		Chaetomium metabolite
chaetoviridin E
chaetoviridin E : An azaphilone that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a chloro group at position 5, a methyl group at position 6a, a 2-methylbut-2-enoyl group at position 9 and a 3-methylpent-1-en-1-yl group at position 3. It has been isolated from Chaetomium globosum.		2.5220azaphilone;
enone;
gamma-lactone;
organic heterotricyclic compound;
organochlorine compound		Chaetomium metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.0610
Disease Resistance
The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.		02.3110