Compounds > 1,3,5-triphenylformazan
Page last updated: 2024-12-11

1,3,5-triphenylformazan

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1,3,5-Triphenylformazan: A Versatile Molecule with Significance in Research

1,3,5-triphenylformazan is an organic compound with the chemical formula C19H16N4. It is a reddish-purple solid with a melting point of 124-126 °C. It is primarily used as a **colorimetric reagent** for the detection and quantification of various metal ions.

**Here's why it's important for research:**

* **Colorimetric Detection:** 1,3,5-triphenylformazan forms colored complexes with different metal ions, including **copper, nickel, cobalt, and palladium**. The color change allows researchers to detect and quantify these metals visually or using spectrophotometric methods.
* **Analytical Chemistry:** This property makes it valuable in various analytical applications, including **water quality monitoring, environmental analysis, and pharmaceutical analysis**.
* **Sensitivity:** 1,3,5-triphenylformazan exhibits **high sensitivity** for certain metal ions, making it suitable for trace analysis.
* **Biosensing:** It has been explored as a potential **biosensing material** for the detection of specific biomolecules, such as enzymes and proteins.
* **Organic Synthesis:** The molecule itself is a useful intermediate in **organic synthesis**, particularly for the preparation of other formazan derivatives with specific properties.
* **Material Science:** 1,3,5-triphenylformazan exhibits interesting **optical and electronic properties**, making it a potential material for applications in optoelectronics and molecular electronics.

**Furthermore, the research on 1,3,5-triphenylformazan continues to evolve:**

* **New applications:** Ongoing research aims to develop new applications for this molecule, including its use as a **dye for textiles and plastics**, a **pigment in paints**, and a **photocatalyst**.
* **Improved sensitivity:** Researchers are exploring ways to enhance the sensitivity and selectivity of 1,3,5-triphenylformazan for specific metal ions and biomolecules.
* **New derivatives:** Synthesis of new derivatives with tailored properties is being investigated to expand its applications in diverse fields.

**In conclusion, 1,3,5-triphenylformazan is a versatile molecule with significant applications in various research fields. Its colorimetric properties, sensitivity, and potential for further development make it a valuable tool for scientists in analytical chemistry, biosensing, materials science, and organic synthesis.**

1,3,5-triphenylformazan: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5463277
CHEMBL ID2311896
SCHEMBL ID322062
SCHEMBL ID491429
MeSH IDM0498106

Synonyms (37)

Synonym
AKOS015840697
nsc2931
1,5-triphenylformazan
531-52-2
diazene, phenylhydrazone
toluene, .alpha.-(phenylazo)-.alpha.-(phenylhydrazono)-
nsc-2931
diimide, phenylhydrazone
formazan,n,n'-triphenyl-
formazan,3,5-triphenyl-
triphenylformazan
nsc56467
nsc-56467
1,3,5-triphenylformazan
diimide, benzoylphenyl-, phenylhydrazone
toluene, alpha-(phenylazo)-alpha-(phenylhydrazono)-
benzaldehyde, alpha-(phenylazo)-, phenylhydrazone
formazan, c,n,n'-triphenyl-
formazan, 1,3,5-triphenyl-
y3ap4ytr8u ,
nsc 2931
unii-y3ap4ytr8u
einecs 208-509-1
methanone, phenyl(2-phenyldiazenyl)-, 2-phenylhydrazone
diazene, benzoylphenyl-, phenylhydrazone
n'-(phenylamino)-n-(phenylimino)benzenecarboximidamide
AKOS025310699
CHEMBL2311896 ,
SCHEMBL322062
SCHEMBL491429
J-650250
(ne,z)-n'-(phenylamino)-n-(phenylimino)benzene-1-carboximidamide
W-105767
BEIHVSJTPTXQGB-FACDVXMNSA-N
methanone, phenyl[2-phenyldiazenyl]-, 2-phenylhydrazone
GS-3200
bdbm50489379

Research Excerpts

Toxicity

ExcerptReferenceRelevance
"A simple generic toxicity method (test) is proposed using baker's yeast to mediate the reduction of the colourless triphenyltetrazolium chloride (TTC) to red, 1,3,5-triphenyl formazan, which can be extracted by dimethyl sulfoxide (DMSO), enabling the identification of reducible toxic compounds (e."( YTOX: a rapid toxicity test based on the dehydrogenase activity of Saccharomyces cerevisiae for detection of contaminants in water samples.
Andrino, FG; da Silva, APM; de Lira, SP; Duarte, KMR; Ferrarezi, JA; Gomes, LH; Kamogawa, MY; Laguna, SE; Tavares, ACL, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Integrase Human immunodeficiency virus 1IC50 (µMol)100.00000.00051.544310.0000AID725310; AID725311
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID725309Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
AID725311Inhibition of wild type HIV1 integrase 3'-processing activity using 5'-end 32P-labeled linear oligonucleotide as substrate preincubated for 30 mins2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
AID725310Inhibition of wild type HIV1 integrase strand transfer activity using 5'-end 32P-labeled linear oligonucleotide as substrate preincubated for 30 mins2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
AID725308Cytotoxicity against human HCT116 p53 +/+ and -/- cells after 72 hrs by MTT assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
AID725313Inhibition of human Flag-tagged LEDGF interaction to His6-tagged HIV1 integrase expressed in Escherichia coli BL21 (DE3) preincubated for 20 mins measured after 1 hr by AlphaScreen proximity luminescent assay2013Bioorganic & medicinal chemistry, Feb-15, Volume: 21, Issue:4
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.79

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.79 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index5.24 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.79)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dimethyl sulfoxide
Dimethyl Sulfoxide: A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during CRYOPRESERVATION. Dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation.. dimethyl sulfoxide : A 2-carbon sulfoxide in which the sulfur atom has two methyl substituents.		7.4820sulfoxide;
volatile organic compound		alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger
toluene
methylbenzene : Any alkylbenzene that is benzene substituted with one or more methyl groups.		7.4110methylbenzene;
toluenes;
volatile organic compound		cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent
fipronil
fipronil: has low mammalian toxicity; structure given in first source. fipronil : A racemate comprising equimolar amounts of (R)- and (S)-fipronil.. 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile : A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively.		2.2110(trifluoromethyl)benzenes;
dichlorobenzene;
nitrile;
primary amino compound;
pyrazoles;
sulfoxide
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC).		2.0810carbohydrazideantitubercular agent;
drug allergen
triphenyltetrazolium
triphenyltetrazolium: RN given refers to parent cpd. 2,3,5-triphenyltetrazolium : An organic cation that is tetrazole carrying three phenyl substituents at positions 2, 3 and 5.		3.0340organic cation
gentian violet
Gentian Violet: A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties.. crystal violet : An organic chloride salt that is the monochloride salt of crystal violet cation. It has been used in creams for the topical treatment of bacterial and fungal infections, being effective against some Gram-positive bacteria (notably Staphylococcus species) and some pathogenic fungi (including Candida species) but use declined following reports of animal carcinogenicity. It has also been used for dying wood, silk, and paper, as well as a histological stain.		2.0810organic chloride saltanthelminthic drug;
antibacterial agent;
antifungal agent;
antiseptic drug;
histological dye
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		2.2110cadmium molecular entity;
zinc group element atom
formazans
Formazans: Colored azo compounds formed by the reduction of tetrazolium salts. Employing this reaction, oxidoreductase activity can be determined quantitatively in tissue sections by allowing the enzymes to act on their specific substrates in the presence of tetrazolium salts.		3.3660
2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone
2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone: structure in first source		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0810
Electrolytes
Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)		02.1310