Page last updated: 2024-11-05

salicyl hydrazide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Salicyl hydrazide is an organic compound with the formula C7H7N2O2. It is a white solid that is soluble in water and ethanol. Salicyl hydrazide is used in the synthesis of other organic compounds, such as dyes and pharmaceuticals. It is also used as an analytical reagent and a fungicide. Salicyl hydrazide is a potent inhibitor of monoamine oxidase (MAO), an enzyme that breaks down neurotransmitters such as dopamine, norepinephrine, and serotonin. Studies have shown that salicyl hydrazide has anti-inflammatory, analgesic, and antipyretic effects. It also exhibits antimicrobial activity against a range of bacteria and fungi. Salicyl hydrazide is being studied for its potential use in the treatment of Parkinson's disease, Alzheimer's disease, and other neurological disorders. It is also being investigated for its potential use in the treatment of cancer and other diseases. Its synthesis involves the reaction of salicylaldehyde with hydrazine hydrate.'

2-hydroxybenzohydrazide: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID13637
CHEMBL ID170058
SCHEMBL ID161525
MeSH IDM0040770

Synonyms (60)

Synonym
salicyclohydrazine
einecs 213-311-3
salicoyl hydrazide
salicylic hydrazide
salicylohydrazide
nsc 652
salicylic acid hydrazide
benzoic acid, 2-hydroxy-, hydrazide
o-hydroxybenzoylhydrazide
2-hydroxybenzoylhydrazide
salicycic acid hydrazide
936-02-7
salicylic acid, hydrazide
salicyloylhydrazine
o-hydroxybenzhydrazide
nsc652
2-hydroxybenzoic acid hydrazide
o-hydroxylbenzhydrazide
salicyl hydrazide
o-hydroxybenzoylhydrazine
o-hydroxybenzoic acid hydrazide
salicyloyl hydrazide
nsc-652
2-hydroxybenzohydrazide
2-hydroxybenzoylhydrazine
inchi=1/c7h8n2o2/c8-9-7(11)5-3-1-2-4-6(5)10/h1-4,10h,8h2,(h,9,11
salicyloyl hydrazide, 98%
MAYBRIDGE1_007678
STK053411
BRD-K80800852-001-01-8
HMS563E22
CHEMBL170058 ,
2-hydroxy-benzoic acid hydrazide
S0242
bdbm50056886
AKOS000120449
salicylhydrazide
BBL008416
2-hydroxybenzhydrazide
benzoylhydrazine, o-hydroxy
2-hydroxybenzoic hydrazide
2-hydroxybenzene-1-carbohydrazide
salicylyl hydrazine
FT-0612580
SCHEMBL161525
salicoylhydrazine
salicyclic acid hydrazide
DTXSID0061321
salicyloylhydrazone
SEW 04563
STR00212
o-hydroxybenzoic hydrazide
2-hydroxybenzoyl hydrazide
2-hydroxybenzenecarboxylic acid hydrazide
mfcd00007599
F1099-0053
CS-W004074
EN300-18163
R5T5F3Q8HR
Z57241860
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Integrase Human immunodeficiency virus 1IC50 (µMol)59.00000.00051.544310.0000AID93518; AID93519; AID93521; AID93522
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID93518Inhibition of HIV-1 integrase enzyme by 3'-processing method (experiment 1)1997Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6
Hydrazide-containing inhibitors of HIV-1 integrase.
AID93519Inhibition of HIV-1 integrase enzyme by 3'-processing method (experiment 2)1997Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6
Hydrazide-containing inhibitors of HIV-1 integrase.
AID93522Inhibition of HIV-1 integrase enzyme by integration method (experiment 2)1997Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6
Hydrazide-containing inhibitors of HIV-1 integrase.
AID93521Inhibition of HIV-1 integrase enzyme by integration method (experiment 1)1997Journal of medicinal chemistry, Mar-14, Volume: 40, Issue:6
Hydrazide-containing inhibitors of HIV-1 integrase.
AID1060953Cytotoxicity against human HCA-7 cells expressing COX-2, 5-LOX, CD44v6 assessed as growth inhibition after 24 hrs by MTT assay2014Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's3 (20.00)29.6817
2010's10 (66.67)24.3611
2020's1 (6.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 26.67

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index26.67 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index5.18 (4.65)
Search Engine Demand Index24.72 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (26.67)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]