7-hydroxy-4-phenyl-8-(1-piperidinylmethyl)-1-benzopyran-2-one : no description available [CHeBI]
| ID Source | ID |
|---|---|
| PubMed CID | 5360356 |
| CHEMBL ID | 1312987 |
| CHEBI ID | 116562 |
| Synonym |
|---|
| brn 1297095 |
| 7-hydroxy-4-phenyl-8-(piperidinomethyl)coumarin |
| coumarin, 7-hydroxy-4-phenyl-8-(piperidinomethyl)- |
| OPREA1_211574 |
| smr000080082 |
| 7-hydroxy-4-phenyl-8-(1-piperidinylmethyl)-2h-chromen-2-one |
| MLS000065505 |
| OPREA1_499950 |
| CHEBI:116562 |
| 7-hydroxy-4-phenyl-8-(piperidin-1-ylmethyl)chromen-2-one |
| AKOS001629665 |
| 7-hydroxy-4-phenyl-8-(piperidin-1-ylmethyl)-2h-chromen-2-one |
| STK711897 |
| 5-20-03-00407 (beilstein handbook reference) |
| 10549-67-4 |
| HMS2392P23 |
| CHEMBL1312987 |
| Q27199449 |
| 7-hydroxy-4-phenyl-8-(1-piperidinylmethyl)-1-benzopyran-2-one |
| DTXSID50147156 |
| SR-01000443028-1 |
| sr-01000443028 |
| mfcd01731752 |
| Class | Description |
|---|---|
| neoflavonoid | Any 1-benzopyran with an aryl substituent at position 4. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds. |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) |
|---|---|---|---|---|
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | AID893 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 31.6228 | AID893 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 35.4813 | AID2147 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 4.4668 | AID485281 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 15.8489 | AID1476 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 15.8489 | AID504937 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | AID1030 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 3.1623 | AID2326 |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.8489 | AID894 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 7.0648 | AID540253; AID540263 |
| snurportin-1 | Homo sapiens (human) | Potency | 7.0648 | AID540253; AID540263 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 2.9093 | AID540253 |
| geminin | Homo sapiens (human) | Potency | 23.1093 | AID624296 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 3.1623 | AID900 |
| Caspase-7 | Homo sapiens (human) | Potency | 3.1623 | AID889 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 ISSN: 1552-4922 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 ISSN: 1557-8127 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | 2022 | The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X | |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | 2022 | The Journal of biological chemistry, 08, Volume: 298, Issue:8 ISSN: 1083-351X | |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 ISSN: 1945-7170 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LSM-26505 | neoflavonoid | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| 7'-hydroxy-4'-(4-methoxyphenyl)-4,4,5'-trimethyl-2-spiro[1,3-diazinane-6,2'-3,4-dihydro-2H-1-benzopyran]thione | neoflavonoid | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| calophyllolid | neoflavonoid | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| mammeisin | neoflavonoid | metabolite | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 8-(diethylaminomethyl)-7-hydroxy-4-phenyl-1-benzopyran-2-one | neoflavonoid | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| 8-[[butyl(ethyl)amino]methyl]-7-hydroxy-4-phenyl-1-benzopyran-2-one | neoflavonoid | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| serratin | neoflavonoid | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| 3'-Hydroxy-5,7,4'-trimethoxy-4-phenylcoumarin | neoflavonoid | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| 4-(4-Methoxyphenyl)-5,7-dihydroxychroman-2-one | neoflavonoid | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 | |||
| crolibulin | neoflavonoid | 0 | 0 | low | 0 | 0 | 0 | 0 | 0 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Inflammation | 0 | 2010 | 2010 | 14.0 | high | 0 | 0 | 0 | 1 | 0 | 0 | |
| Innate Inflammatory Response | 0 | 2010 | 2010 | 14.0 | high | 0 | 0 | 0 | 1 | 0 | 0 |