Page last updated: 2024-09-27

Historic Trauma

Clinical distress among descendants of survivors of mass trauma, as if they had suffered through the same extreme historic circumstances. Symptoms may persist through generations.

Synonyms(5)

Synonym
Transgenerational Trauma
Intergenerational Trauma
Historical Trauma
Historical Psychological Trauma
Historic Trauma

Research Excerpts

Research

Studies (7)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's0 (0.00)12.5806
2000's0 (0.00)18.1394
2010's1 (14.29)28.8240
2020's6 (85.71)9.53
DrugIndicatedRelationship StrengthStudiesTrials
acetylcarnitine0low10
corticosterone0low10
cetylpyridinium chloride anhydrous0low10
isomethyleugenol0low10

Protein Targets (101)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, Ferritin light chain1001
acetylcholinesterase1001
hypoxia-inducible factor 1 alpha subunit1001
RAR-related orphan receptor gamma2002
SMAD family member 21001
USP1 protein, partial1001
SMAD family member 31001
TDP1 protein2002
GLI family zinc finger 32002
Microtubule-associated protein tau1001
AR protein2002
caspase 7, apoptosis-related cysteine protease1001
estrogen receptor 2 (ER beta)1001
nuclear receptor subfamily 1, group I, member 31001
progesterone receptor2002
glucocorticoid receptor [Homo sapiens]2002
retinoic acid nuclear receptor alpha variant 12002
retinoid X nuclear receptor alpha2002
estrogen-related nuclear receptor alpha3003
farnesoid X nuclear receptor2002
estrogen nuclear receptor alpha2002
67.9K protein1001
peroxisome proliferator-activated receptor delta1001
peroxisome proliferator activated receptor gamma1001
vitamin D (1,25- dihydroxyvitamin D3) receptor2002
caspase-31001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a2002
activating transcription factor 61001
thyrotropin-releasing hormone receptor1001
v-jun sarcoma virus 17 oncogene homolog (avian)1001
vitamin D3 receptor isoform VDRA1001
thyroid hormone receptor beta isoform 22002
heat shock protein beta-12002
mitogen-activated protein kinase 12002
nuclear factor erythroid 2-related factor 2 isoform 12002
nuclear receptor ROR-gamma isoform 11001
survival motor neuron protein isoform d2002
Voltage-dependent calcium channel gamma-2 subunit1001
Cellular tumor antigen p531001
Glutamate receptor 21001
Caspase-20011
Inositol monophosphatase 11001
ATPase family AAA domain-containing protein 51001
Ataxin-21001
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
thioredoxin reductase1001
pregnane X receptor1001
NFKB1 protein, partial1001
GALC protein1001
Thrombopoietin1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
nonstructural protein 11001
pregnane X nuclear receptor1001
G1001
IDH11001
euchromatic histone-lysine N-methyltransferase 21001
thyroid stimulating hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
chromobox protein homolog 11001
thyroid hormone receptor beta isoform a1001
nuclear factor erythroid 2-related factor 2 isoform 21001
serine/threonine-protein kinase mTOR isoform 11001
geminin1001
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0202
Solute carrier family 22 member 30101
Solute carrier family 22 member 30101
Interferon beta1001
HLA class I histocompatibility antigen, B alpha chain 1001
Sex hormone-binding globulin0011
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0011
Androgen receptor0101
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
C-8 sterol isomerase0101
Solute carrier organic anion transporter family member 1A10101
Nuclear receptor ROR-gamma1001
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Solute carrier family 22 member 10202
GABA theta subunit1001
Inositol hexakisphosphate kinase 11001
Sigma non-opioid intracellular receptor 10101
Gamma-aminobutyric acid receptor subunit epsilon1001
Solute carrier family 22 member 20202
cytochrome P450 2C9, partial1001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]