Turkesterone : no description available [CHeBI]
| ID Source | ID |
|---|---|
| PubMed CID | 14376672 |
| CHEMBL ID | 2087140 |
| SCHEMBL ID | 140174 |
| CHEBI ID | 191170 |
| MeSH ID | M0068822 |
| Synonym |
|---|
| 2,3,11,14,20,22,25-heptahydroxycholestenone |
| (2beta,3beta,5beta,11alpha,22r)-2,3,11,14,20,22,25-heptahydroxycholest-7-en-6-one |
| turkesterone |
| CHEBI:191170 |
| (2s,3r,5r,9r,10r,11r,13r,14s,17s)-2,3,11,14-tetrahydroxy-10,13-dimethyl-17-[(2r,3r)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-6-one |
| 41451-87-0 |
| 53e6z3f8zg , |
| unii-53e6z3f8zg |
| CHEMBL2087140 |
| cholest-7-en-6-one, 2,3,11,14,20,22,25-heptahydroxy-, (2.beta.,3.beta.,5.beta.,11.alpha.,22r)- |
| (2.beta.,3.beta.,5.beta.,11.alpha.,22r)-2,3,11,14,20,22,25-heptahydroxycholest-7-en-6-one |
| WSBAGDDNVWTLOM-XHZKDPLLSA-N |
| SCHEMBL140174 |
| AC-35148 |
| AKOS032946018 |
| HY-N2548 |
| CS-0022820 |
| Q27261101 |
| MS-29224 |
| Class | Description |
|---|---|
| steroid | Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene. |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID683084 | Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 75% inhibition of cell proliferation at compound-doxorubicin ratio of 81.5:1 after 48 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11 ISSN: 1520-4804 | Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter. |
| AID683081 | Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 50% inhibition of cell proliferation at compound-doxorubicin ratio of 81.5:1 after 48 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11 ISSN: 1520-4804 | Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter. |
| AID1293713 | Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by MTS assay | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 ISSN: 1464-3405 | Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2. |
| AID683087 | Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 95% inhibition of cell proliferation at compound-doxorubicin ratio of 81.5:1 after 48 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11 ISSN: 1520-4804 | Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter. |
| AID1293709 | Antiviral activity against Dengue virus 2 DN454009A infected in human HuH7 cells assessed as inhibition of viral RNA level measured 72 hrs post infection by qRT-PCR method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 ISSN: 1464-3405 | Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2. |
| AID1293714 | Selectivity index, ratio of CC50 for human HuH7 cells to EC50 for Dengue virus 2 DN454009A infected in human HuH7 cells | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 ISSN: 1464-3405 | Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2. |
| AID683076 | Inhibition of human ABCB1 pump expressed in mouse L5178 cells assessed as fluorescence activity ratio at 20 uM for 10 mins by flow cytometry relative to control | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11 ISSN: 1520-4804 | Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| glyburide | monochlorobenzenes; N-sulfonylurea | anti-arrhythmia drug; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor; hypoglycemic agent | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 | |
| methandrostenolone | organic molecular entity | 1985 | 2012 | 25.5 | low | 0 | 1 | 0 | 0 | 1 | 0 | ||
| ecdysone | 14alpha-hydroxy steroid; 22-hydroxy steroid; 25-hydroxy steroid; 2beta-hydroxy steroid; 3beta-sterol; 6-oxo steroid; ecdysteroid | prohormone | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 | |
| dactinomycin | actinomycin | mutagen | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 | |
| ecdysterone | 14alpha-hydroxy steroid; 20-hydroxy steroid; 22-hydroxy steroid; 25-hydroxy steroid; 2beta-hydroxy steroid; 3beta-sterol; ecdysteroid; phytoecdysteroid | animal metabolite; plant metabolite | 1984 | 2013 | 24.1 | high | 0 | 2 | 2 | 1 | 3 | 0 | |
| phytosterols | 1984 | 2012 | 26.0 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alloxan Diabetes | 0 | 1985 | 1999 | 32.0 | high | 0 | 1 | 1 | 0 | 0 | 0 | |
| Anxiety | 0 | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| Depression | 0 | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| Diseases, Occupational | 0 | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| Fibrodysplasia Ossificans Progressiva | 0 | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| Hyperglycemia | 0 | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| Hyperglycemia, Postprandial | 0 | 2012 | 2012 | 12.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 | |
| Myositis Ossificans | 0 | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |