| ID Source | ID |
|---|---|
| PubMed CID | 14376672 |
| CHEMBL ID | 2087140 |
| CHEBI ID | 191170 |
| SCHEMBL ID | 140174 |
| MeSH ID | M0068822 |
| Synonym |
|---|
| 2,3,11,14,20,22,25-heptahydroxycholestenone |
| (2beta,3beta,5beta,11alpha,22r)-2,3,11,14,20,22,25-heptahydroxycholest-7-en-6-one |
| turkesterone |
| CHEBI:191170 |
| (2s,3r,5r,9r,10r,11r,13r,14s,17s)-2,3,11,14-tetrahydroxy-10,13-dimethyl-17-[(2r,3r)-2,3,6-trihydroxy-6-methylheptan-2-yl]-2,3,4,5,9,11,12,15,16,17-decahydro-1h-cyclopenta[a]phenanthren-6-one |
| 41451-87-0 |
| 53e6z3f8zg , |
| unii-53e6z3f8zg |
| CHEMBL2087140 |
| cholest-7-en-6-one, 2,3,11,14,20,22,25-heptahydroxy-, (2.beta.,3.beta.,5.beta.,11.alpha.,22r)- |
| (2.beta.,3.beta.,5.beta.,11.alpha.,22r)-2,3,11,14,20,22,25-heptahydroxycholest-7-en-6-one |
| WSBAGDDNVWTLOM-XHZKDPLLSA-N |
| SCHEMBL140174 |
| AC-35148 |
| AKOS032946018 |
| HY-N2548 |
| CS-0022820 |
| Q27261101 |
| MS-29224 |
Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Turkesterone is a phytoecdysteroid possessing an 11alpha-hydroxyl group. " | ( Synthesis and biological activities of turkesterone 11alpha-acyl derivatives. Bourne, P; Coll, J; Dhadialla, TS; Dinan, L; Hormann, RE; Lafont, R; Saatov, Z; Tsitsekli, A; Whiting, P, 2003) | 2.03 |
| Class | Description |
|---|---|
| steroid | Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID683084 | Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 75% inhibition of cell proliferation at compound-doxorubicin ratio of 81.5:1 after 48 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11 | Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter. |
| AID683081 | Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 50% inhibition of cell proliferation at compound-doxorubicin ratio of 81.5:1 after 48 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11 | Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter. |
| AID1293713 | Cytotoxicity against human HuH7 cells assessed as reduction in cell viability after 72 hrs by MTS assay | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2. |
| AID683087 | Inhibition of human ABCB1 expressed in mouse L5178 cells assessed as 95% inhibition of cell proliferation at compound-doxorubicin ratio of 81.5:1 after 48 hrs by MTT assay | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11 | Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter. |
| AID1293709 | Antiviral activity against Dengue virus 2 DN454009A infected in human HuH7 cells assessed as inhibition of viral RNA level measured 72 hrs post infection by qRT-PCR method | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2. |
| AID1293714 | Selectivity index, ratio of CC50 for human HuH7 cells to EC50 for Dengue virus 2 DN454009A infected in human HuH7 cells | 2016 | Bioorganic & medicinal chemistry letters, May-01, Volume: 26, Issue:9 | Ecdysones from Zoanthus spp. with inhibitory activity against dengue virus 2. |
| AID683076 | Inhibition of human ABCB1 pump expressed in mouse L5178 cells assessed as fluorescence activity ratio at 20 uM for 10 mins by flow cytometry relative to control | 2012 | Journal of medicinal chemistry, Jun-14, Volume: 55, Issue:11 | Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.
| This Compound (59.31) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 18 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||