Compounds > sameridine
Page last updated: 2024-12-06

sameridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

sameridine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID65996
CHEMBL ID2104504
SCHEMBL ID419071
MeSH IDM0293755

Synonyms (17)

Synonym
sameridine
n-ethyl-1-hexyl-n-methyl-4-phenylpiperidine-4-carboxamide
n-ethyl-1-hexyl-n-methyl-4-phenylisonipecotamide
sameridine [inn]
nqp2y50y6b ,
143257-97-0
unii-nqp2y50y6b
AKOS015909863
CHEMBL2104504
SCHEMBL419071
DTXSID30162367
4-piperidinecarboxamide,n-ethyl-1-hexyl-n-methyl-4-phenyl-
4-piperidinecarboxamide, n-ethyl-1-hexyl-n-methyl-4-phenyl-
us9656961, example 00127
bdbm309407
n-ethyl-1-hexyl-n-methyl-4-phenyl-4-piperidinecarboxamide
Q7409294

Research Excerpts

Overview

Sameridine is a new compound with both local anesthetic and opioid properties (partial micro -opioid receptor agonist) It is intended to be used intrathecally in order to provide both surgical anaesthesia and prolonged postoperative analgesia.

ExcerptReferenceRelevance
"Sameridine is a new compound with both local anesthetic and opioid properties (partial micro -opioid receptor agonist). "( Hypercarbic and hypoxic ventilatory responses after intrathecal administration of bupivacaine and sameridine.
Arlander, E; Eriksson, LI; Lindahl, SG; Modalen, AO; Westman, L, 2003)		1.98
"Sameridine is a new candidate drug with both local anaesthetic and analgesic properties. "( Determination of free concentration of sameridine in blood plasma by ultrafiltration and coupled-column liquid chromatography.
Arvidsson, T; Eklund, E; Norsten-Höög, C, 1998)		2.01
"Sameridine is a new compound with local anesthetic and analgesic properties when injected intrathecally. "( Sameridine is safe and effective for spinal anesthesia: a comparative dose-ranging study with lidocaine for inguinal hernia repair.
Chan, V; Ganapathy, S; Greengrass, R; Heierson, A; Mulroy, MF, 1999)		3.19
"Sameridine is a type of compound with both local anaesthetic and analgesic effects with the clinical intention to be used intrathecally (i.t.) in order to provide both surgical anaesthesia and prolonged postoperative analgesia. "( Sameridine--intrathecal injection in the rat. Morphometric and morphologic analysis after chronic administration and effects on spinal cord blood flow.
Ask, AL; Gordh, T; Karlsten, R; Kristensen, JD; Svensson, BA, 1999)		3.19
"Sameridine is a new type of compound with both local anaesthetic and analgesic properties, when administered intrathecally."( Determination of sameridine in blood plasma by nitrogen-selective gas chromatography.
Arvidsson, T; Neidenström, P; Norsten-Höög, C, 2001)		1.37

Effects

ExcerptReferenceRelevance
"Sameridine has both local anesthetic and partial mu-opioid receptor agonistic properties. "( The effects on resting ventilation of intravenous infusions of morphine or sameridine, a novel molecule with both local anesthetic and opioid properties.
Arlander, E; Eriksson, LI; Lindahl, SG; Osterlund, A, 1999)		1.98
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (55.56)18.2507
2000's4 (44.44)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials4 (44.44%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (55.56%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bupivacaine
Bupivacaine: A widely used local anesthetic agent.. 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide : A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.. bupivacaine : A racemate composed of equimolar amounts of dextrobupivacaine and levobupivacaine. Used (in the form of its hydrochloride hydrate) as a local anaesthetic.		8.821aromatic amide;
piperidinecarboxamide;
tertiary amino compound
clofibrate
angiokapsul: contains clofibrate & insoitolnicotinate		210aromatic ether;
ethyl ester;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist
fomepizole
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.. fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.		210pyrazolesantidote;
EC 1.1.1.1 (alcohol dehydrogenase) inhibitor;
protective agent
lidocaine
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.. lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.		8.3811benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
proadifen
Proadifen: An inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.		210diarylmethane
morphine
Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.		4.3522morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
piperidines
Piperidines: A family of hexahydropyridines.		6.1794
ConditionIndicatedRelationship StrengthStudiesTrials
Anoxemia
[description not available]		03.411
Hypoxia
Sub-optimal OXYGEN levels in the ambient air of living organisms.		03.411
Complication, Intraoperative
[description not available]		01.9910
Acute Post-operative Pain
[description not available]		01.9910
Pain, Postoperative
Pain during the period after surgery.		01.9910
Neuromuscular Blockade
The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.		01.9910
Inguinal Hernia
[description not available]		08.3811
Hernia, Inguinal
An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.		03.3811
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		0210