Compounds > salifungin
Page last updated: 2024-11-06

salifungin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Salifungin is a natural product isolated from the fungus *Aspergillus fumigatus*. It exhibits potent antifungal activity against a broad range of fungal pathogens, including *Candida albicans*, *Cryptococcus neoformans*, and *Aspergillus fumigatus*. Salifungin is a macrocyclic lactone, and its biosynthesis is thought to involve a polyketide synthase (PKS) pathway. The compound is of significant interest to researchers for its potential as a novel antifungal drug. Salifungin has been shown to inhibit the growth of fungal cells by targeting the enzyme squalene synthase, which is essential for ergosterol biosynthesis. Ergosterol is a key component of the fungal cell membrane and is crucial for cell viability. Salifungin's selective toxicity towards fungal cells makes it a promising lead compound for the development of new antifungal agents. Furthermore, Salifungin exhibits activity against drug-resistant fungal strains, making it a potential solution to the growing problem of antifungal drug resistance. Studies on Salifungin include its mechanism of action, structure-activity relationships, and its potential for therapeutic applications. '

multifungin: RN given for mixture of salicylic acid, 5-bromo-4'-chlorosalicylanilide (Salifungin) & bamipine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID77254
CHEMBL ID153192
CHEBI ID135394
SCHEMBL ID152257
MeSH IDM0111279

Synonyms (52)

Synonym
unii-6gk715pwmq
nsc 526297
6gk715pwmq ,
bromosalicylchloranilide
einecs 222-957-5
multifungin (van)
3679-64-9
nsc-526297
benzamide, 5-bromo-n-(4-chlorophenyl)-2-hydroxy-
salicylanilide, 5-bromo-4'-chloro-
5-bromosalicyl-4'-chloranilide
multifungin
nsc526297
salifungin
5-bromo-4'-chlorosalicylanilide
salifungen
5-bromosalicyl-4-chloroanilide
5-bromo-n-(4-chlorophenyl)-2-hydroxy-benzamide
bromochlorosalicylanilide ,
CHEBI:135394
5-bromo-4'-chloro-2-hydroxybenzanilide
B0897
qbsgxibyuqjhmj-uhfffaoysa-
inchi=1/c13h9brclno2/c14-8-1-6-12(17)11(7-8)13(18)16-10-4-2-9(15)3-5-10/h1-7,17h,(h,16,18)
CHEMBL153192
AKOS003382268
5-bromo-n-(4-chlorophenyl)-2-hydroxybenzamide
5-brom-4'-chlorsalicylanilid
bromosalicylchloranilide [mi]
bromochlorosalicylanilide [who-dd]
clobromsalan
5-bromosalicyl-4'-chloroanilide
bromosalicychloranilidine
S6451
SCHEMBL152257
AC-27860
DTXSID80190256
SR-01000872604-2
sr-01000872604
mfcd00020132
AS-66607
CS-0020293
HY-B2140
5-bromo-4-chloro-2-hydroxybenzanilide
BCP24289
Q4973727
FT-0757179
DB13696
AMY41396
bromosalicylchloranilide;salifungin
T70837
A874281
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzamides
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1593592Inhibition of recombinant Cryptosporidium hominis TS-DHFR expressed in Escherichia coli PA414 assessed as reduction in DHFR steady state activity at 500 uM using [3',5',7,9-3H]-H2folate as substrate preincubated for 10 mins before NADPH addition for 5 min2019Bioorganic & medicinal chemistry letters, 06-01, Volume: 29, Issue:11
Novel allosteric covalent inhibitors of bifunctional Cryptosporidium hominis TS-DHFR from parasitic protozoa identified by virtual screening.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (75.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.13 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (12.50%)4.05%
Observational0 (0.00%)0.25%
Other7 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
fendiline
Fendiline: Coronary vasodilator; inhibits calcium function in muscle cells in excitation-contraction coupling; proposed as antiarrhythmic and antianginal agents.		2.2510diarylmethane
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		1.9610aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
deoxyuridine
[no description available]		2.2110pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2,3-dihydroxyquinoxaline
2,3-dihydroxyquinoxaline: fluorescent oxalic acid deriv.		2.2110
sertraline
Sertraline: A selective serotonin uptake inhibitor that is used in the treatment of depression.. sertraline : A member of the class of tetralins that is tetralin which is substituted at positions 1 and 4 by a methylamino and a 3,4-dichlorophenyl group, respectively (the S,S diastereoisomer). A selective serotonin-reuptake inhibitor (SSRI), it is administered orally as the hydrochloride salt as an antidepressant for the treatment of depression, obsessive-compulsive disorder, panic disorder and post-traumatic stress disorder.		2.2510dichlorobenzene;
secondary amino compound;
tetralins		antidepressant;
serotonin uptake inhibitor
bamipine
bamipine: RN given refers to parent cpd; structure		1.9610aromatic amine
4'-bromosalicylanilide
4'-bromosalicylanilide: photoproduct from UV-irradiation of tribromsalan; structure		2.2110
monensin
Monensin: An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.. monensin A : A spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle.		2.2510cyclic hemiketal;
monocarboxylic acid;
polyether antibiotic;
spiroketal		antifungal agent;
coccidiostat;
ionophore
glycosides
[no description available]		1.9610
vortioxetine
Vortioxetine: A piperazine derivative that acts as a serotonin reuptake inhibitor, as a 5-HT3 receptor antagonist, and 5-HT1A receptor agonist. It is used for the treatment of anxiety and depression.. vortioxetine : An N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder.		2.2510aryl sulfide;
N-arylpiperazine		antidepressant;
anxiolytic drug;
serotonergic agonist;
serotonergic antagonist
piperidines
Piperidines: A family of hexahydropyridines.		2.8740
salicylates
Salicylates: The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.. hydroxybenzoate : Any benzoate derivative carrying a single carboxylate group and at least one hydroxy substituent.. salicylates : Any salt or ester arising from reaction of the carboxy group of salicylic acid, or any ester resulting from the condensation of the phenolic hydroxy group of salicylic acid with an organic acid.. salicylate : A monohydroxybenzoate that is the conjugate base of salicylic acid.		2.8740monohydroxybenzoateplant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Fungal Diseases
[description not available]		01.9310
Mycoses
Diseases caused by FUNGI.		01.9310
Moniliasis, Oral
[description not available]		02.3620
Candidiasis, Oral
Infection of the mucous membranes of the mouth by a fungus of the genus CANDIDA. (Dorland, 27th ed)		02.3620
Mouth Diseases
Diseases involving the MOUTH.		01.9610
Aphthae
[description not available]		01.9610
Stomatitis, Aphthous
A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)		01.9610
2019 Novel Coronavirus Disease
[description not available]		02.2510
Contact Dermatitis
[description not available]		01.9610
Dermatitis, Contact
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.		01.9610