obolactone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
obolactone : A pyranone isolated from the trunk barks of Cryptocarya obovata and has been shown to exhibit cytotoxicity against the KB cell line. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Cryptocarya | genus | A plant genus of the family LAURACEAE. Members contain cryptofolione, caryachine, grandisin and other compounds. Some PEUMUS species have been reclassified as CRYPTOCARYA.[MeSH] | Lauraceae | A family of mainly aromatic evergreen plants in the order Laurales. The laurel family includes 2,200 species in 45 genera and from these are derived medicinal extracts, essential oils, camphor and other products.[MeSH] |
| Cryptocarya obovata | species | [no description available] | Lauraceae | A family of mainly aromatic evergreen plants in the order Laurales. The laurel family includes 2,200 species in 45 genera and from these are derived medicinal extracts, essential oils, camphor and other products.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 11370316 |
| CHEMBL ID | 452184 |
| CHEBI ID | 66803 |
| SCHEMBL ID | 2328947 |
| MeSH ID | M0505453 |
| Synonym |
|---|
| obolactone |
| chebi:66803 , |
| CHEMBL452184 |
| (2r)-2-[[(2r)-6-oxo-2,3-dihydropyran-2-yl]methyl]-6-[(e)-2-phenylethenyl]-2,3-dihydropyran-4-one |
| (6r)-6-({(2r)-4-oxo-6-[(e)-2-phenylethenyl]-3,4-dihydro-2h-pyran-2-yl}methyl)-5,6-dihydro-2h-pyran-2-one |
| SCHEMBL2328947 |
| 712272-88-3 |
| Q27135435 |
| AKOS040762136 |
| Role | Description |
|---|---|
| antineoplastic agent | A substance that inhibits or prevents the proliferation of neoplasms. |
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Class | Description |
|---|---|
| 2-pyranones | A pyranone based on the structure of 2H-pyran-2-one and its substituted derivatives. |
| 4-pyranones | A pyranone based on the structure of 4H-pyran-4-one and its substituted derivatives. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID489467 | Selectivity index, ratio of IC50 for HEK293 cells to IC50 for Trypanosoma brucei brucei | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14 | 7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata. |
| AID489459 | Antitrypanosomal activity against Trypanosoma brucei brucei | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14 | 7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata. |
| AID402260 | Cytotoxicity against human KB cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5 | Cytotoxic flavonoids and alpha-pyrones from Cryptocarya obovata. |
| AID489465 | Cytotoxicity against human HeLa cells after 72 hrs by Alamar blue assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14 | 7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata. |
| AID489464 | Cytotoxicity against human MCF7 cells after 72 hrs by Alamar blue assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14 | 7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata. |
| AID489463 | Cytotoxicity against human A549 cells after 72 hrs by Alamar blue assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14 | 7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata. |
| AID489462 | Cytotoxicity against HEK239 cells after 72 hrs by Alamar blue assay | 2010 | Bioorganic & medicinal chemistry letters, Jul-15, Volume: 20, Issue:14 | 7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.63) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||