methylsulfonyl benzothiazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

methylsulfonyl benzothiazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	242777
CHEMBL ID	4851001
SCHEMBL ID	2754297
MeSH ID	M0578737

Synonyms (31)

Synonym
BIDD:GT0729
2-(methylsulfonyl)benzothiazole
EN300-23757
2-methanesulfonyl-1,3-benzothiazole
nsc51671
7144-49-2
nsc-51671
benzothiazole, 2-(methylsulfonyl)-
inchi=1/c8h7no2s2/c1-13(10,11)8-9-6-4-2-3-5-7(6)12-8/h2-5h,1h
TIMTEC1_004950
HMS1548A22
2-methylsulfonyl-1,3-benzothiazole
AKOS001288035
2-(methylsulfonyl)-1,3-benzothiazole
2-(methylsulfonyl)benzo[d]thiazole
5P-344S
2-methanesulfonylbenzothiazole
YZOXPLQWARQVEJ-UHFFFAOYSA-N
SCHEMBL2754297
mfcd00142947
2-(methanesulfonyl)-1,3-benzothiazole
DTXSID10287587
CCG-255317
methylsulfonyl benzothiazole
benzothiazole,(methylsulfonyl)-
73544-94-2
CS-0210224
AMY32488
A935519
F83040
CHEMBL4851001

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay ID	Title	Year	Journal	Article
AID540299	A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519	A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities	2011	Antiviral research, Sep, Volume: 91, Issue:3	High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1763223	Thiol reactivity of the compound assessed as compound-TNB2 complex formation using DTNB at 200 uM measured after 1 hr by high-throughput thiol reactivity assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	Discovery of selective fragment-sized immunoproteasome inhibitors.
AID1763211	Inhibition of human chymotrypsin-like beta 5i subunit of iCP assessed as residual activity using suc-LLVY-AMC as flurogenic substrate at 100 uM for 90 mins by fluorescence-based assay	2021	European journal of medicinal chemistry, Jul-05, Volume: 219	Discovery of selective fragment-sized immunoproteasome inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (83.33)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	13.18 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	5.12 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (13.18)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	6 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydrogen sulfide Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed). hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.. thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.	2.11	1	gas molecular entity; hydracid; mononuclear parent hydride; sulfur hydride	Escherichia coli metabolite; genotoxin; metabolite; signalling molecule; toxin; vasodilator agent
cyanoacetic acid cyanoacetic acid: RN given refers to parent cpd; structure. cyanoacetic acid : A monocarboxylic acid that consists of acetic acid bearing a cyano substituent.	2.11	1	monocarboxylic acid
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.11	1	benzenes; phenyl acetates
biotin vitamin B7 : Any member of a group of vitamers that belong to the chemical structural class called biotins that exhibit biological activity against vitamin B7 deficiency. Vitamin B7 deficiency is very rare in individuals who take a normal balanced diet. Foods rich in biotin are egg yolk, liver, cereals, vegetables (spinach, mushrooms) and rice. Symptoms associated with vitamin B7 deficiency include thinning hair, scaly skin rashes around eyes, nose and mouth, and brittle nails. The vitamers include biotin and its ionized and salt forms.	2.11	1	biotins; vitamin B7	coenzyme; cofactor; Escherichia coli metabolite; fundamental metabolite; human metabolite; mouse metabolite; nutraceutical; prosthetic group; Saccharomyces cerevisiae metabolite
sodium sulfide sodium sulfide: see also record for sodium bisulfide; actisoufre is the sodium sulfide component of sulfur-containing thermal springs which is also found in Saccharomyces cerevisiae	2.11	1
2-cyanobenzothiazole 2-cyanobenzothiazole: structure in first source	2.31	1
captax captax: RN given refers to parent cpd. 1,3-benzothiazole-2-thiol : 1,3-Benzothiazole substituted at the 2-position with a sulfanyl group.	2.31	1	aryl thiol; benzothiazoles	carcinogenic agent; metabolite
2-mercaptobenzimidazole 2-mercaptobenzimidazole: purine synthesis antimetabolite; RN given refers to parent cpd	2.31	1
2-mercaptobenzoxazole [no description available]	2.31	1	benzoxazole
6-amino-2-mercaptobenzothiazole [no description available]	2.31	1
5-chloro-1h-benzimidazole-2-thiol 5-chloro-1H-benzimidazole-2-thiol: trypanocidal	2.31	1
5-chloro-2-mercaptobenzothiazole [no description available]	2.31	1
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.11	1	cysteinium	fundamental metabolite

Condition	Indicated	Relationship Strength	Studies	Trials
Encephalitis, Polio [description not available]	0	2.06	1	0
Poliomyelitis An acute infectious disease of humans, particularly children, caused by any of three serotypes of human poliovirus (POLIOVIRUS). Usually the infection is limited to the gastrointestinal tract and nasopharynx, and is often asymptomatic. The central nervous system, primarily the spinal cord, may be affected, leading to rapidly progressive paralysis, coarse FASCICULATION and hyporeflexia. Motor neurons are primarily affected. Encephalitis may also occur. The virus replicates in the nervous system, and may cause significant neuronal loss, most notably in the spinal cord. A rare related condition, nonpoliovirus poliomyelitis, may result from infections with nonpoliovirus enteroviruses. (From Adams et al., Principles of Neurology, 6th ed, pp764-5)	0	2.06	1	0

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