laherradurin and isomurisolenin

laherradurin has been researched along with isomurisolenin* in 1 studies

Other Studies

1 other study(ies) available for laherradurin and isomurisolenin

Article	Year
Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I. Bioorganic & medicinal chemistry letters, 2001, Mar-12, Volume: 11, Issue:5 To study the relevance of the terminal alpha,beta-unsaturated gamma-methyl-gamma-lactone moiety of the antitumoral acetogenins of Annonaceae for potent mitochondrial complex I inhibition, we have prepared a series of semisynthetic acetogenins with modifications only in this part of the molecule, from the natural rolliniastatin-1 (1) and cherimolin-1 (2). Some of the hydroxylated derivatives (1b, 1d and 1e) in addition to two infrequent natural beta-hydroxy gamma-methyl gamma-lactone acetogenins, laherradurin (3) and itrabin (4), are more potent complex I inhibitors than any other known compounds. Topics: Animals; Antineoplastic Agents; Cattle; Electron Transport Complex I; Furans; Lactones; Magnoliopsida; Mitochondria, Heart; Molecular Structure; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Submitochondrial Particles	2001

Article

Year

Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.

Bioorganic & medicinal chemistry letters, 2001, Mar-12, Volume: 11, Issue:5

To study the relevance of the terminal alpha,beta-unsaturated gamma-methyl-gamma-lactone moiety of the antitumoral acetogenins of Annonaceae for potent mitochondrial complex I inhibition, we have prepared a series of semisynthetic acetogenins with modifications only in this part of the molecule, from the natural rolliniastatin-1 (1) and cherimolin-1 (2). Some of the hydroxylated derivatives (1b, 1d and 1e) in addition to two infrequent natural beta-hydroxy gamma-methyl gamma-lactone acetogenins, laherradurin (3) and itrabin (4), are more potent complex I inhibitors than any other known compounds.

Topics: Animals; Antineoplastic Agents; Cattle; Electron Transport Complex I; Furans; Lactones; Magnoliopsida; Mitochondria, Heart; Molecular Structure; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Submitochondrial Particles

2001