Page last updated: 2024-12-06

gyromitrin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

gyromitrin: isolated from edible mushroom Gyromitra (Helvella) esculenta; inhalation hallucinogen; highly toxic; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9548611
CHEBI ID	5583
SCHEMBL ID	2932999
MeSH ID	M0047343

Synonyms (39)

Synonym
CHEBI:5583
acetaldehyde n-methyl-n-formylhydrazone
n'-ethylidene-n-methylformohydrazide
hydrazinecarboxaldehyde, ethylidenemethyl-
acetaldehyde, n-formyl-n-methylhydrazone
n-methyl-n-formylhydrazone acetaldehyde
formic acid, ethylidenemethylhydrazide
formic acid, 2-ethylidene-1-methylhydrazide
wln: vhn1&nu2
acetaldehyde n-formyl-n-methylhydrazone
nsc-240877
acetaldehyde n-methylformylhydrazone
nsc240877
brn 1922396
hydrazine carboxyaldehyde, ethylidenemethyl-
hydrazine carboxaldehyde, ethylidenemethyl-
hsdb 3489
ethylidene gyromitrin
ccris 5705
nsc 240877
gyromitrin
C08305
16568-02-8
AKOS006279315
s9j72g0t46 ,
unii-s9j72g0t46
hydrazinecarboxaldehyde, ethylidenemethyl-, (e)-
61748-21-8
gyromitrin [iarc]
gyromitrin [hsdb]
CCG-214846
IMAGWKUTFZRWSB-HWKANZROSA-N
n'-[(e)-ethylidene]-n-methylformic hydrazide #
formic acid, n'-ethylidene-n-methyl-hydrazide
SCHEMBL2932999
n'-[(1e)-ethylidene]-n-methylformohydrazide
DTXSID50872971
n-[(e)-ethylideneamino]-n-methylformamide
BRD-K13037776-001-01-2

Research Excerpts

Dosage Studied

Excerpt	Relevance	Reference
" In mice exposed to MMH according to a dosing scheme identical to that reported to induce tumours in this species, O6-methylguanine was present in liver and kidney DNA."	( Methylation of rat and mouse DNA by the mushroom poison gyromitrin and its metabolite monomethylhydrazine. Bergman, K; Hellenäs, KE, 1992)	0.28

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	11 (73.33)	18.7374
1990's	1 (6.67)	18.2507
2000's	3 (20.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (95.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetaldehyde Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.. acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.. aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.. acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.	10.14	15	aldehyde	carcinogenic agent; EC 3.5.1.4 (amidase) inhibitor; electron acceptor; Escherichia coli metabolite; human metabolite; mouse metabolite; mutagen; oxidising agent; Saccharomyces cerevisiae metabolite; teratogenic agent
2,2'-dipyridyl 2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.	3.11	1	bipyridine	chelator; ferroptosis inhibitor
hexobarbital Hexobarbital: A barbiturate that is effective as a hypnotic and sedative.. hexobarbital : A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.	1.95	1	barbiturates
aminopyrine Aminopyrine: A pyrazolone with analgesic, anti-inflammatory, and antipyretic properties but has risk of AGRANULOCYTOSIS. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of CYTOCHROME P-450 metabolic activity in LIVER FUNCTION TESTS.. aminophenazone : A pyrazolone that is 1,2-dihydro-3H-pyrazol-3-one substituted by a dimethylamino group at position 4, methyl groups at positions 1 and 5 and a phenyl group at position 2. It exhibits analgesic, anti-inflammatory, and antipyretic properties.	1.95	1	pyrazolone; tertiary amino compound	antipyretic; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic
monomethylhydrazine Monomethylhydrazine: Hydrazine substituted by one methyl group.	7.67	3
n-methyl-n-formylhydrazine N-methyl-N-formylhydrazine: structure	1.95	1
pentafluorobenzoyl chloride pentafluorobenzoyl chloride: RN given refers to parent cpd. pentafluorobenzoyl chloride : The acid chloride of pentafluorobenzoic acid. It is a sensitive derivatising reagent for the analysis of amines, amides and phenols by electron capture gas chromatography.	2.03	1	acyl chloride; perfluorinated compound	chromatographic reagent
orellanine orellanine: isolated from Cortinarius orellanus	3.11	1	bipyridines
amanitins Amanitins: Cyclic peptides extracted from carpophores of various mushroom species. They are potent inhibitors of RNA polymerases in most eukaryotic species, blocking the production of mRNA and protein synthesis. These peptides are important in the study of transcription. Alpha-amanitin is the main toxin from the species Amanitia phalloides, poisonous if ingested by humans or animals.	3.11	1
amatoxin [no description available]	3.11	1

Condition	Relationship Strength	Studies
Mushroom Poisoning Poisoning from ingestion of mushrooms, primarily from, but not restricted to, toxic varieties.	3.99	5
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	2.93	1
Rhabdomyolysis Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.	2.93	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.96	1
Carcinoma, Ehrlich Tumor A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.	1.96	1
Experimental Neoplasms [description not available]	2.36	2
Adenocarcinoma, Basal Cell [description not available]	1.96	1
Adenoma, Basal Cell [description not available]	1.96	1
Carcinoma, Epidermoid [description not available]	1.96	1
Cancer of Lung [description not available]	1.96	1
Papilloma, Squamous Cell [description not available]	1.96	1
Cancer of Penis [description not available]	1.96	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1.96	1
Adenoma A benign epithelial tumor with a glandular organization.	1.96	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1.96	1
Lung Neoplasms Tumors or cancer of the LUNG.	1.96	1
Papilloma A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)	1.96	1
Penile Neoplasms Cancers or tumors of the PENIS or of its component tissues.	1.96	1
Acute Liver Injury, Drug-Induced [description not available]	1.95	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	1.95	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.95	1

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