Compounds > epiquinamide
Page last updated: 2024-11-12

epiquinamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

epiquinamide: quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11241028
CHEMBL ID460758
SCHEMBL ID2464033
MeSH IDM0460037

Synonyms (4)

Synonym
CHEMBL460758
SCHEMBL2464033
epiquinamide
n-[(1r,9ar)-2,3,4,6,7,8,9,9a-octahydro-1h-quinolizin-1-yl]acetamide
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID356557Agonist activity at rat nicotinic alpha3beta4 receptor expressed in human KXalpha-3-beta-4R2 cells at 50 uM by cell based membrane potential assay relative to (+/-)-epibatidine2003Journal of natural products, Oct, Volume: 66, Issue:10
Bioassay-guided isolation of epiquinamide, a novel quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor.
AID356554Agonist activity at human nicotinic alpha-1-beta-1-gamma-delta receptor expressed in human TE-671 cells at 50 uM by cell based membrane potential assay relative to (+/-)-epibatidine2003Journal of natural products, Oct, Volume: 66, Issue:10
Bioassay-guided isolation of epiquinamide, a novel quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor.
AID356555Agonist activity at human nicotinic alpha3beta2 receptor expressed in human SH-SY5Y cells at 50 uM by cell based membrane potential assay relative to (+/-)-epibatidine2003Journal of natural products, Oct, Volume: 66, Issue:10
Bioassay-guided isolation of epiquinamide, a novel quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor.
AID356558Agonist activity at human nicotinic alpha4beta2 receptor expressed in human K177 cells at 50 uM by cell based membrane potential assay relative to (+/-)-epibatidine2003Journal of natural products, Oct, Volume: 66, Issue:10
Bioassay-guided isolation of epiquinamide, a novel quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor.
AID356556Agonist activity at human nicotinic alpha3beta4 receptor expressed in human IMR32 cells at 50 uM by cell based membrane potential assay relative to (+/-)-epibatidine2003Journal of natural products, Oct, Volume: 66, Issue:10
Bioassay-guided isolation of epiquinamide, a novel quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (61.54)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methyl acrylate
[no description available]		2.0810enoate ester
2-piperidone
2-piperidone: structure given in first source. piperidin-2-one : A delta-lactam that is piperidine which is substituted by an oxo group at position 2.		2.4620delta-lactam;
piperidones		EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor
iridium
Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.		2.1110cobalt group element atom;
platinum group metal atom
samarium
Samarium: An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.		2.0810f-block element atom;
lanthanoid atom
iodine
[no description available]		2.0810halide anion;
monoatomic iodine		human metabolite
alkenes
[no description available]		2.1110
azides
Azides: Organic or inorganic compounds that contain the -N3 group.. azide : Any nitrogen molecular entity containing the group -N3.		2.0510pseudohalide anionmitochondrial respiratory-chain inhibitor
swainsonine
Swainsonine: An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.. swainsonine : An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.		7.1110indolizidine alkaloidantineoplastic agent;
EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor;
immunological adjuvant;
plant metabolite
glutarimide
[no description available]		2.0310dicarboximide;
piperidones
nicotine
(S)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.		2.03103-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
lupinine
lupinine: RN given refers to parent cpd(1R-trans)-isomer; structure		7.4620quinolizidine alkaloid
sperm motility inhibitor 2
[no description available]		2.0810
piperidines
Piperidines: A family of hexahydropyridines.		2.4420
ConditionIndicatedRelationship StrengthStudiesTrials