Compounds > dysidiolide
Page last updated: 2024-10-14

dysidiolide

Description

dysidiolide: inhibits the protein tyrosine phosphatase CDC25; cladocoran B is the olefinic regioisomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11269661
CHEMBL ID1765353
MeSH IDM0336744

Synonyms (13)

Synonym
CHEMBL1765353 ,
dysidiolide
bdbm50341997
(5r)-5-hydroxy-4-((1r)-1-hydroxy-2-((1r,2r,5s,8as)-1,2,3,5,6,7,8,8a-octahydro-1,2,5-trimethyl-5-(4-methyl-4-penten-1-yl)-1-naphthalenyl)ethyl)-2(5h)-furanone
2(5h)-furanone, 5-hydroxy-4-((1r)-1-hydroxy-2-((1r,2r,5s,8as)-1,2,3,5,6,7,8,8a-octahydro-1,2,5-trimethyl-5-(4-methyl-4-penten-1-yl)-1-naphthalenyl)ethyl)-, (5r)-
182136-94-3
JV53JWY86D ,
(-)-dysidiolide
dysidiolide [mi]
cladocoran b
unii-jv53jwy86d
Q27281710
(2r)-3-[(1r)-2-[(1r,2r,5s,8as)-1,2,5-trimethyl-5-(4-methylpent-4-enyl)-2,3,6,7,8,8a-hexahydronaphthalen-1-yl]-1-hydroxyethyl]-2-hydroxy-2h-furan-5-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
M-phase inducer phosphatase 1Homo sapiens (human)IC50 (µMol)13.66670.02204.20249.4000AID241804; AID42952; AID51858; AID51863; AID51865; AID593355
M-phase inducer phosphatase 2Homo sapiens (human)IC50 (µMol)87.00000.10002.31039.5100AID51887
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (17)

Processvia Protein(s)Taxonomy
regulation of cyclin-dependent protein serine/threonine kinase activityM-phase inducer phosphatase 1Homo sapiens (human)
G1/S transition of mitotic cell cycleM-phase inducer phosphatase 1Homo sapiens (human)
G2/M transition of mitotic cell cycleM-phase inducer phosphatase 1Homo sapiens (human)
cell population proliferationM-phase inducer phosphatase 1Homo sapiens (human)
response to radiationM-phase inducer phosphatase 1Homo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycleM-phase inducer phosphatase 1Homo sapiens (human)
cellular response to UVM-phase inducer phosphatase 1Homo sapiens (human)
positive regulation of DNA replicationM-phase inducer phosphatase 1Homo sapiens (human)
cell divisionM-phase inducer phosphatase 1Homo sapiens (human)
positive regulation of G2/MI transition of meiotic cell cycleM-phase inducer phosphatase 1Homo sapiens (human)
G2/M transition of mitotic cell cycleM-phase inducer phosphatase 2Homo sapiens (human)
mitotic cell cycleM-phase inducer phosphatase 2Homo sapiens (human)
oocyte maturationM-phase inducer phosphatase 2Homo sapiens (human)
protein phosphorylationM-phase inducer phosphatase 2Homo sapiens (human)
female meiosis IM-phase inducer phosphatase 2Homo sapiens (human)
positive regulation of cell population proliferationM-phase inducer phosphatase 2Homo sapiens (human)
positive regulation of G2/M transition of mitotic cell cycleM-phase inducer phosphatase 2Homo sapiens (human)
positive regulation of cytokinesisM-phase inducer phosphatase 2Homo sapiens (human)
positive regulation of mitotic cell cycleM-phase inducer phosphatase 2Homo sapiens (human)
cell divisionM-phase inducer phosphatase 2Homo sapiens (human)
positive regulation of G2/MI transition of meiotic cell cycleM-phase inducer phosphatase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
phosphoprotein phosphatase activityM-phase inducer phosphatase 1Homo sapiens (human)
protein tyrosine phosphatase activityM-phase inducer phosphatase 1Homo sapiens (human)
protein bindingM-phase inducer phosphatase 1Homo sapiens (human)
protein kinase bindingM-phase inducer phosphatase 1Homo sapiens (human)
protein-folding chaperone bindingM-phase inducer phosphatase 1Homo sapiens (human)
phosphoprotein phosphatase activityM-phase inducer phosphatase 2Homo sapiens (human)
protein tyrosine phosphatase activityM-phase inducer phosphatase 2Homo sapiens (human)
protein bindingM-phase inducer phosphatase 2Homo sapiens (human)
protein kinase bindingM-phase inducer phosphatase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (6)

Processvia Protein(s)Taxonomy
nucleoplasmM-phase inducer phosphatase 1Homo sapiens (human)
cytosolM-phase inducer phosphatase 1Homo sapiens (human)
nucleusM-phase inducer phosphatase 1Homo sapiens (human)
cytoplasmM-phase inducer phosphatase 1Homo sapiens (human)
spindle poleM-phase inducer phosphatase 2Homo sapiens (human)
nucleoplasmM-phase inducer phosphatase 2Homo sapiens (human)
centrosomeM-phase inducer phosphatase 2Homo sapiens (human)
cytosolM-phase inducer phosphatase 2Homo sapiens (human)
nucleusM-phase inducer phosphatase 2Homo sapiens (human)
cytoplasmM-phase inducer phosphatase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID593355Inhibition of human Cdc25A2011Bioorganic & medicinal chemistry, Apr-01, Volume: 19, Issue:7
Using small molecules to target protein phosphatases.
AID42952Compound was evaluated for the inhibition of Cdc25A phosphatase by using p-nitrophenylphosphate as substrate1998Journal of medicinal chemistry, Nov-19, Volume: 41, Issue:24
Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel.
AID241804Inhibitory concentration against dual-specificity phosphatase Cell division cycle (Cdc) 25A2004Bioorganic & medicinal chemistry letters, Aug-16, Volume: 14, Issue:16
Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue.
AID51863Inhibitory activity tested against cell division cycle 25A (assay using fluorescein diphosphate (FDP) as substrate)2001Journal of medicinal chemistry, Mar-01, Volume: 44, Issue:5
Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase.
AID51858Concentration required to inhibit human Cell division cycle 25A activity2004Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12
Design and synthesis of dysidiolide analogs from vitamin D3: novel class of Cdc25A inhibitors.
AID51887The compound was tested for its inhibitory activity against Cell division cycle 25B2000Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22
Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.
AID82311The compound was tested for its inhibitory activity against HL-60 human leukemia cell line2000Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22
Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.
AID51865The compound was tested for its inhibitory activity against Cell division cycle 25A2000Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22
Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.
AID200427The compound was tested for its inhibitory activity against SBC-5 human lung cancer cell line2000Bioorganic & medicinal chemistry letters, Nov-20, Volume: 10, Issue:22
Synthesis of the novel analogues of dysidiolide and their structure-activity relationship.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (20)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (10.00)18.2507
2000's16 (80.00)29.6817
2010's2 (10.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		4.15160butan-4-olidemetabolite;
neurotoxin
propadiene
[no description available]		210allenes
butenolide
butenolide: inhibits experimental allergic encephalomyelitis in rats. butenolide : A gamma-lactone that consists of a 2-furanone skeleton and its substituted derivatives.		2.0310butenolide
alkenes
[no description available]		210
ertiprotafib
ertiprotafib: a hypoglycemic agent; structure in first source		2.0610
nsc 95397
[no description available]		2.06101,4-naphthoquinones
nsc 663284
NSC 663284: structure in first source		2.0610quinolone
okadaic acid
[no description available]		210polycyclic ethercalcium ionophore;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
marine metabolite
4-phenyl-4-oxo-2-hydroxybuten-2-oic acid
2,4-dioxo-4-phenylbutanoic acid: structure in first source		2.0610
sesquiterpenes
[no description available]		2.0110
cholecalciferol
Cholecalciferol: Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24.. calciol : A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.		2.4120D3 vitamins;
hydroxy seco-steroid;
seco-cholestane;
secondary alcohol;
steroid hormone		geroprotector;
human metabolite
manoalide
manoalide: phospholipase A2 inhibitor; sesterterpene from marine sponge L. variabilis; structure given in first source. manoalide : A sesterterpenoid isolated from the marine sponge Luffariella variabilis and which has been shown to exhibit inhibitory activity towards phospholipase A2.		2.0310butenolide;
lactol;
sesterterpenoid		EC 3.1.1.4 (phospholipase A2) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
metabolite
msi 1436
3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate: a spermine-cholesterol adduct which causes reversible suppression of food and fluid intake in mammals resulting in profound weight loss, not associated with other signs or symptoms of illness, and which exhibits antidiabetic properties in genetically obese mice		2.0610bile acid
ConditionIndicatedRelationship StrengthStudiesTrials