Page last updated: 2024-12-08
dk 118
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
DK 118: stimulates dopaminergic receptors in the central & peripheral nervous system; RN given refers to parent cpd; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 145953 |
| CHEMBL ID | 538100 |
| MeSH ID | M0098810 |
Synonyms (9)
| Synonym |
|---|
| dk-118 |
| dk 118 |
| 1-naphthalenol, 6-(dipropylamino)-5,6,7,8-tetrahydro-2-methyl-, hydrobromide |
| CHEMBL538100 |
| n,n-dipropyl-5-hydroxy-6-methyl-2-aminotetralin |
| 88935-99-3 |
| 6-(dipropylamino)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-ol--hydrogen bromide (1/1) |
| DTXSID801008574 |
| 6-(dipropylamino)-2-methyl-5,6,7,8-tetrahydronaphthalen-1-ol;hydrobromide |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (5)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID191922 | Compound was evaluated for rotational behavior in rats and (contralateral turning) circling response were recorded at a dose of 11.7 umol/Kg | 1980 | Journal of medicinal chemistry, Jul, Volume: 23, Issue:7 | Derivatives of 5-hydroxy-6-methyl-2-aminotetralin. |
| AID47974 | Inhibition of chronotropic response to cardioaccelerator nerve stimulation in the cat | 1980 | Journal of medicinal chemistry, Jul, Volume: 23, Issue:7 | Derivatives of 5-hydroxy-6-methyl-2-aminotetralin. |
| AID49743 | Compound was evaluated for its action blockade by haloperidol (0.1 mg/kg); yes | 1980 | Journal of medicinal chemistry, Jul, Volume: 23, Issue:7 | Derivatives of 5-hydroxy-6-methyl-2-aminotetralin. |
| AID192049 | Compound was evaluated for rotational behavior in rats and (contralateral turning) circling response were recorded at a dose of 5.85 umol/Kg | 1980 | Journal of medicinal chemistry, Jul, Volume: 23, Issue:7 | Derivatives of 5-hydroxy-6-methyl-2-aminotetralin. |
| AID60588 | Compound was evaluated for emesis action in dogs, administered subcutaneously; Range is (0.03-6.2) | 1980 | Journal of medicinal chemistry, Jul, Volume: 23, Issue:7 | Derivatives of 5-hydroxy-6-methyl-2-aminotetralin. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 26.69
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (26.69) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||