Compounds > dibenzothiophene 5-oxide
Page last updated: 2024-11-05

dibenzothiophene 5-oxide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Dibenzothiophene 5-oxide (DBTO) is a sulfur-containing heterocyclic compound that is an important intermediate in the production of pharmaceuticals, dyes, and other fine chemicals. It is also a major constituent of fossil fuels and is considered a sulfur-containing contaminant. DBTO has been extensively studied for its environmental and health effects, including its role in air pollution and its potential toxicity. DBTO is a key precursor in the formation of sulfated polycyclic aromatic hydrocarbons (PAHs), which are known to be carcinogenic. Research on DBTO focuses on its synthesis, characterization, and its environmental fate and effects. For example, scientists are investigating new methods to remove DBTO from fuels to improve their quality and reduce their environmental impact. '

dibenzothiophene 5-oxide: dibenzothiophene degradation product [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

dibenzothiophene 5-oxide : A member of the class of dibenzothiophenes that is the 5-oxo derivative of dibenzothiophene. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID13898
CHEMBL ID335280
CHEBI ID23683
SCHEMBL ID205562
MeSH IDM0163140

Synonyms (41)

Synonym
2j64h8m52d ,
nsc 170577
unii-2j64h8m52d
dibenzothiopene 5-oxide
nsc-633010
nsc633010
dibenzothiophene 5-oxide
mls003106738 ,
dibenzothiophene sulfoxide
1013-23-6
nsc170577
dibenzothiophene s-oxide
dibenzothiophene, 5-oxide
nsc-170577
C0057
dibenzothiophene-5-oxide
dibenzo[b,d]thiophene, 5-oxide
dibenzo[b,d]thiophene 5-oxide
inchi=1/c12h8os/c13-14-11-7-3-1-5-9(11)10-6-2-4-8-12(10)14/h1-8
dbt-sulfoxide
dbto
CHEMBL335280
chebi:23683 ,
smr001821628
AKOS005166936
SCHEMBL205562
mfcd00046902
dibenzothiophene oxide
dibenzothiophene-s-oxide
dibenzothiophene-5-oxide?
DTXSID5074422
C21149
J-000366
83u ,
dibenzo[b,d]thiophene5-oxide
AS-37620
Q27109805
BAA01323
CS-0155931
A921198
SY056660
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
dibenzothiophenes
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
dibenzothiophene desulfurization313

Bioassays (14)

Assay IDTitleYearJournalArticle
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID227824Bioreduction experiment was conducted by incubation of the sulfoxides with rat liver S-9 fractions in anaerobic conditions (N2, benzaldehyde)2000Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins.
AID227825Bioreduction experiment was conducted by incubation of the sulfoxides with rat liver S-9 fractions in anaerobic conditions (N2, without cofactors)2000Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins.
AID227826Bioreduction experiment was conducted by incubation of the sulfoxides with rat liver S-9 fractions in anaerobic conditions N2)2000Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins.
AID227803Reduction potential (SCE) determined by differential pulse polarography of the sulfoxides with rat liver S-9 fractions2000Journal of medicinal chemistry, Nov-02, Volume: 43, Issue:22
Sulfoxide-containing aromatic nitrogen mustards as hypoxia-directed bioreductive cytotoxins.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (5.26)18.7374
1990's2 (10.53)18.2507
2000's8 (42.11)29.6817
2010's5 (26.32)24.3611
2020's3 (15.79)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.06

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.06 (24.57)
Research Supply Index3.00 (2.92)
Research Growth Index5.06 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.06)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (5.26%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other18 (94.74%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dibenzothiophene
dibenzothiophene : A mancude organic heterotricyclic parent that consists of a thiophene ring flanked by two benzene rings ortho-fused across the 2,3- and 4,5-positions.		4.92110dibenzothiophenes;
mancude organic heterotricyclic parent		keratolytic drug
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		2.0510aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		2.1510arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
2-phenylphenol
2-phenylphenol: RN given refers to parent cpd; structure. biphenyl-2-ol : A member of the class of hydroxybiphenyls that is biphenyl substituted by a hydroxy group at position 2. It is generally used as a post-harvest fungicide for citrus fruits.		2.4620hydroxybiphenylsantifungal agrochemical;
environmental food contaminant
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		5.15140mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
benzyl sulfide
[no description available]		1.9910
diphenyl sulfoxide
diphenyl sulfoxide: electron acceptor for liver aldehyde oxidase		210sulfoxide
methyl phenyl sulfoxide
(methylsulfinyl)benzene : A sulfoxide resulting from the formal oxidation of the sulfur atom of thioanisole.		210benzenes;
sulfoxide
glutamic acid
Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.		2.1510glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		4.2250chalcogen;
nonmetal atom		macronutrient
flavin mononucleotide
Flavin Mononucleotide: A coenzyme for a number of oxidative enzymes including NADH DEHYDROGENASE. It is the principal form in which RIBOFLAVIN is found in cells and tissues.		1.9910
ConditionIndicatedRelationship StrengthStudiesTrials
Innate Inflammatory Response
[description not available]		02.0510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.0510