CGS 23425: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 9874938 |
| CHEMBL ID | 46882 |
| SCHEMBL ID | 281877 |
| MeSH ID | M0281133 |
| Synonym |
|---|
| bdbm50036402 |
| n-[4-(4-hydroxy-3-isopropyl-phenoxy)-3,5-dimethyl-phenyl]-oxalamic acid |
| n-[3,5-dimethyl-4-(4''-hydroxy-3''-isopropylphenoxy)phenyl]oxamic acid |
| ({4-[4-hydroxy-3-(propan-2-yl)phenoxy]-3,5-dimethylphenyl}amino)(oxo)acetic acid |
| n-[3,5-dimethyl-4-(4'-hydroxy-3'-isopropylphenoxy)-phenyl]-oxamic acid |
| cgs 23425 |
| CHEMBL46882 , |
| cgs-23425 |
| SCHEMBL281877 |
| cgs23425 |
| DTXSID7040998 |
| 156740-30-6 |
| 2-[4-(4-hydroxy-3-propan-2-ylphenoxy)-3,5-dimethylanilino]-2-oxoacetic acid |
| n-[3,5-dimethyl-4-(4/'/'-hydroxy-3/'/'-isopropyl-phenoxy) phenyl] oxamic acid |
| n-[3,5-dimethyl-4-(4-hydroxy-3-isopropyl-phenoxy)phenyl]oxamicacid |
| 2-((4-(4-hydroxy-3-isopropylphenoxy)-3,5-dimethylphenyl)amino)-2-oxoacetic acid |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Treatment with CGS 23425 increased activity of the hepatic apo B-100 editosome, apobec-1." | ( Effects of a thyromimetic on apolipoprotein B-100 in rats. Dufresne, J; Hargrove, GM; Matsubara, S; Steele, RE; Stephan, ZF; Wada, Y; Wong, NC, 2000) | 0.65 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Because of the low oral bioavailability of PA 22c, a series of prodrugs was synthesized and screened for oral efficacy in the CFR assay." | ( Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs. Boyer, SH; Cable, EE; Erion, MD; Fujitaki, JM; Godwin, JL; Hecker, SJ; Hou, J; Jacintho, JD; Jiang, H; Li, H; Li, W; Reddy, MV; Schulz, WG; Wu, R, 2008) | 0.35 |
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor alpha | Homo sapiens (human) | Ki | 0.0005 | 0.0002 | 0.0039 | 0.0096 | AID345695 |
| Thyroid hormone receptor beta | Homo sapiens (human) | Ki | 0.0005 | 0.0001 | 0.0007 | 0.0023 | AID345696 |
| Thyroid hormone receptor beta | Rattus norvegicus (Norway rat) | IC50 (µMol) | 0.0002 | 0.0002 | 0.0083 | 0.0350 | AID146670 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| nucleus | Thyroid hormone receptor alpha | Homo sapiens (human) |
| nucleoplasm | Thyroid hormone receptor alpha | Homo sapiens (human) |
| cytosol | Thyroid hormone receptor alpha | Homo sapiens (human) |
| chromatin | Thyroid hormone receptor alpha | Homo sapiens (human) |
| nucleus | Thyroid hormone receptor alpha | Homo sapiens (human) |
| RNA polymerase II transcription regulator complex | Thyroid hormone receptor alpha | Homo sapiens (human) |
| nucleoplasm | Thyroid hormone receptor beta | Homo sapiens (human) |
| nuclear body | Thyroid hormone receptor beta | Homo sapiens (human) |
| RNA polymerase II transcription regulator complex | Thyroid hormone receptor beta | Homo sapiens (human) |
| chromatin | Thyroid hormone receptor beta | Homo sapiens (human) |
| nucleus | Thyroid hormone receptor beta | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID173066 | Percent change in serum HDL level was determined in hypercholesterolemic rats at 25 ug/Kg upon peroral administration | 1995 | Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4 | Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. |
| AID3248 | Inhibition of [125I]L-T3 binding to rat hepatic 3,5,3''-triiodo-L-thyronine receptor | 2000 | Bioorganic & medicinal chemistry letters, Aug-07, Volume: 10, Issue:15 | Synthesis and biological activity of phenoxyphenyl oxamic acid derivatives related to L-thyronine. |
| AID345695 | Displacement of [125I]3,5,3'-triiodo-L-thyronine from His-tagged human recombinant TRalpha1 by scintillation proximity assay | 2008 | Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22 | Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs. |
| AID146670 | In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor | 1995 | Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4 | Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. |
| AID173069 | Percent change in serum LDL level was determined in hypercholesterolemic rats at 25 ug/Kg upon peroral administration | 1995 | Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4 | Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. |
| AID185045 | Minimum effective dose was determined in hypercholesterolemic rats for lowering total cholesterol level compared to control upon peroral administration | 1995 | Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4 | Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. |
| AID345696 | Displacement of [125I]3,5,3'-triiodo-L-thyronine His-tagged human recombinant TRbeta1 by scintillation proximity assay | 2008 | Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22 | Synthesis and biological evaluation of a series of liver-selective phosphonic acid thyroid hormone receptor agonists and their prodrugs. |
| AID176209 | Effective dose was determined in hypercholesterolemic rats for lowering total serum cholesterol compared to control upon peroral administration | 1995 | Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4 | Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. |
| AID173587 | Dose which was not showing any cardiac effect in normal cholesterol rats upon peroral administration | 1995 | Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4 | Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. |
| AID160006 | In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor | 1995 | Journal of medicinal chemistry, Feb-17, Volume: 38, Issue:4 | Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.23) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||